Research Article
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The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival

Year 2024, Volume: 41 Issue: 3, 626 - 635, 30.09.2024

Abstract

The exact staging of esophagus cancers are very important for the planning of treatment and analyse of prognosis. The aim of our study is the evaluation of last staging criteria of esophagus cancers and the comparison of sixth and seventh TNM staging systems. The eighty five patients who underwent resection due to esophagus cancer in the Thoracic Surgery Department of 19 Mayıs University, Faculty of Medicine between January 2003 and December 2014 were evaluated retrospectively. The clinical staging and the factors that effects the survival are evaluated both by the 6th and 7th TNM by using radiological imaging and upper gastrointestinal system endoscopy. The postoperative mean survival time is evaluated as 44.46 ± 6.71 months is measured for 85 patients who were resected by the diagnosis of esophagus cancer. The most common cause of admission to the hospital are dysphagia and weight loss. The 76.5 % of the patients are squamous cell carcinoma and 23.5 % of the patients are adenocarcinoma as a histopathological diagnosis of cancer. The most highest postoperative survival (57. 50 ± 27.86 months) is reported after the McKeown surgery. According to the seventh staging system the tumor depth, the number of metastatic nodes and metastasis affect the postoperative prognosis and ratio of survival negatively.It is showed that the effected lymph nodes and the number of effected lymph nodes are the most valuable criterias in the seventh TNM staging system and it is evaluated that more powerful results are gained when it is compared with the sixth TNM staging system.

Ethical Statement

This study was approved by The Medical Research Ethics Committee with the reference number:(Ref. No. OMU MREC 2015/289)

Project Number

Ref. No. OMU MREC 2015/289

References

  • Manzoni G, Pedrazzani C, Verlato G, et al. Comparison of old and new TNM systems for nodal staging in adenocarcinoma of the gastro-oesophageal junction. British Journal of Surgery 2004; 91: 296-303.
  • Rice TW, Blackstone EH, Rusch VW. 7th Edition of the AJCC Cancer Staging Manual: Esophagus and Esophagogastric Junction. Ann SurgOncol2010; 17: 1721-1724.
  • Kim HI, Cheong JH, Song KJ, et al. Staging of Adenocarcinoma of the Esophagogastric Junction: Comparison of AJCC 6th and 7th Gastric and 7th Esophageal Staging Systems. Ann SurgOncol2013; 20: 2713-2720.
  • Hsu PK, Wu YC, Chou TY, et al. Comparison of the 6th and 7th editions of the American Joint Committee on Cancer Tumor-Node-Metastasis staging system in patients with resected esophageal carcinoma. Ann Thorac Surg. 2010; 89: 1024-31.
  • Altorki NK, Zhou XK, Stiles B, et al. Total number of resected lymph nodes predicts survival in esophageal cancer. Ann Surg. 2008; 248: 221-6.
  • Bogoevski D, Onken F, Koenig A, et al. Is it time for a new TNM classification in esophagealcarcinoma? Ann Surg. 2008; 247: 633-41.
  • Roder JD, Busch R, Stein HJ, Fink U, Siewert JR. Ratio of invaded to removed lymph nodes as a predictor of survival in squamous cell carcinoma of the oesophagus. Br J Surg1994; 81: 410-3.
  • Yam PC, Tong D, Law S. Comparisons of Sixth and Seventh Edition of the American Joint Cancer Committee Staging Systems for Esophageal Cancer. Ann SurgOncol2014; 21: 583-588.
  • Doki Y, Ishikawa O, Takachi K, et al. Association of the primary tumor location with the site of tumor recurrence after curative resection of thoracic esophageal carcinoma. World J Surg. 2005; 29: 700-7.
  • Eloubeidi MA, Desmond R, Arguedas MR, et al. Prognostic factors for the survival of patients with esophageal carcinoma in the U.S: The importance of tumor length and lymph node status. Cancer 2002; 95: 1434-1443.
  • Rice TW, Rusch VW, Apperson-Hansen C, et al. Worldwide esophageal cancer collaboration. Dis Esophagus. 2009; 22: 1-8.
  • Thompson SK, Ruszkiewicz AR, Jamieson GG, et al. Improving the accuracy of TNM staging in esophageal cancer: a pathological review of resected specimens. Annals of Surgical Oncology 15(12): 3447–3458.
  • Kato H, Tachimori Y, Watanabe H, Iizuka T. Evaluation of thenew (1987) TNM classification for thoracic esophageal tumors. Int J Cancer. 1993; 53: 220-3.
  • Talsma K, Hagen P, Grotenhuis BA, et al. Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer. Ann SurgOncol2012; 19: 2142-48.
  • Xu Y, Jiang Y, Yu X. Analysis of new N-category on prognosis of esophageal cancer with positive lymph nodes in a Chinese population. RadiolOncol 2013; 47(1): 63-70.
  • Peyre CG, Hagen JA, DeMeester SR, et al. The number of lymph nodes removed predicts survival in esophageal cancer: an interational study on the impact of extent of surgical resection. Ann Surg. 2008; 248: 549-56.
  • Rizk NP, Ishwaran H, Rice TW, et al. Optimum lymphadenectomy for esophageal cancer. Ann Surg. 2010; 251: 46-50.
  • Tong DK, Kwong DL, Law S, Wong KH, Wong J. Cervical nodal metastasis from intrathoracic esophageal squamous cell carcinoma is not necessarily an incurable disease. J GastrointestSurg. 2008; 12: 1638-45.
  • Mehta SP, Jose P, Mirza A, et al. Comparison of the prognostic value of the 6th and 7th editions the Union for International Cancer Control TNM staging system in patients with lower esophageal cancer undergoing neoadjuvant chemotherapy followed by surgery. Diseases of the Esophagus2013; 26: 182-188.
  • Gaur P, Hofstetter WL, Bekele BN, et al. Comparison between established and the Worldwide Esophageal Cancer Collaboration staging systems. Ann ThoracSurg. 2010; 89: 1797-803, 1804 e 1791-3.
Year 2024, Volume: 41 Issue: 3, 626 - 635, 30.09.2024

Abstract

Project Number

Ref. No. OMU MREC 2015/289

References

  • Manzoni G, Pedrazzani C, Verlato G, et al. Comparison of old and new TNM systems for nodal staging in adenocarcinoma of the gastro-oesophageal junction. British Journal of Surgery 2004; 91: 296-303.
  • Rice TW, Blackstone EH, Rusch VW. 7th Edition of the AJCC Cancer Staging Manual: Esophagus and Esophagogastric Junction. Ann SurgOncol2010; 17: 1721-1724.
  • Kim HI, Cheong JH, Song KJ, et al. Staging of Adenocarcinoma of the Esophagogastric Junction: Comparison of AJCC 6th and 7th Gastric and 7th Esophageal Staging Systems. Ann SurgOncol2013; 20: 2713-2720.
  • Hsu PK, Wu YC, Chou TY, et al. Comparison of the 6th and 7th editions of the American Joint Committee on Cancer Tumor-Node-Metastasis staging system in patients with resected esophageal carcinoma. Ann Thorac Surg. 2010; 89: 1024-31.
  • Altorki NK, Zhou XK, Stiles B, et al. Total number of resected lymph nodes predicts survival in esophageal cancer. Ann Surg. 2008; 248: 221-6.
  • Bogoevski D, Onken F, Koenig A, et al. Is it time for a new TNM classification in esophagealcarcinoma? Ann Surg. 2008; 247: 633-41.
  • Roder JD, Busch R, Stein HJ, Fink U, Siewert JR. Ratio of invaded to removed lymph nodes as a predictor of survival in squamous cell carcinoma of the oesophagus. Br J Surg1994; 81: 410-3.
  • Yam PC, Tong D, Law S. Comparisons of Sixth and Seventh Edition of the American Joint Cancer Committee Staging Systems for Esophageal Cancer. Ann SurgOncol2014; 21: 583-588.
  • Doki Y, Ishikawa O, Takachi K, et al. Association of the primary tumor location with the site of tumor recurrence after curative resection of thoracic esophageal carcinoma. World J Surg. 2005; 29: 700-7.
  • Eloubeidi MA, Desmond R, Arguedas MR, et al. Prognostic factors for the survival of patients with esophageal carcinoma in the U.S: The importance of tumor length and lymph node status. Cancer 2002; 95: 1434-1443.
  • Rice TW, Rusch VW, Apperson-Hansen C, et al. Worldwide esophageal cancer collaboration. Dis Esophagus. 2009; 22: 1-8.
  • Thompson SK, Ruszkiewicz AR, Jamieson GG, et al. Improving the accuracy of TNM staging in esophageal cancer: a pathological review of resected specimens. Annals of Surgical Oncology 15(12): 3447–3458.
  • Kato H, Tachimori Y, Watanabe H, Iizuka T. Evaluation of thenew (1987) TNM classification for thoracic esophageal tumors. Int J Cancer. 1993; 53: 220-3.
  • Talsma K, Hagen P, Grotenhuis BA, et al. Comparison of the 6th and 7th Editions of the UICC-AJCC TNM Classification for Esophageal Cancer. Ann SurgOncol2012; 19: 2142-48.
  • Xu Y, Jiang Y, Yu X. Analysis of new N-category on prognosis of esophageal cancer with positive lymph nodes in a Chinese population. RadiolOncol 2013; 47(1): 63-70.
  • Peyre CG, Hagen JA, DeMeester SR, et al. The number of lymph nodes removed predicts survival in esophageal cancer: an interational study on the impact of extent of surgical resection. Ann Surg. 2008; 248: 549-56.
  • Rizk NP, Ishwaran H, Rice TW, et al. Optimum lymphadenectomy for esophageal cancer. Ann Surg. 2010; 251: 46-50.
  • Tong DK, Kwong DL, Law S, Wong KH, Wong J. Cervical nodal metastasis from intrathoracic esophageal squamous cell carcinoma is not necessarily an incurable disease. J GastrointestSurg. 2008; 12: 1638-45.
  • Mehta SP, Jose P, Mirza A, et al. Comparison of the prognostic value of the 6th and 7th editions the Union for International Cancer Control TNM staging system in patients with lower esophageal cancer undergoing neoadjuvant chemotherapy followed by surgery. Diseases of the Esophagus2013; 26: 182-188.
  • Gaur P, Hofstetter WL, Bekele BN, et al. Comparison between established and the Worldwide Esophageal Cancer Collaboration staging systems. Ann ThoracSurg. 2010; 89: 1797-803, 1804 e 1791-3.
There are 20 citations in total.

Details

Primary Language English
Subjects Gastroenterology and Hepatology
Journal Section Research Article
Authors

Mehmet Pirzirenli 0000-0002-1831-2710

Ayşen Taslak Şengül 0000-0002-1558-8228

Yasemin Büyükkarabacak 0000-0001-9676-9313

Ahmet Başoğlu 0000-0002-6312-5658

Project Number Ref. No. OMU MREC 2015/289
Publication Date September 30, 2024
Submission Date July 11, 2024
Acceptance Date August 11, 2024
Published in Issue Year 2024 Volume: 41 Issue: 3

Cite

APA Pirzirenli, M., Taslak Şengül, A., Büyükkarabacak, Y., Başoğlu, A. (2024). The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival. Journal of Experimental and Clinical Medicine, 41(3), 626-635.
AMA Pirzirenli M, Taslak Şengül A, Büyükkarabacak Y, Başoğlu A. The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival. J. Exp. Clin. Med. September 2024;41(3):626-635.
Chicago Pirzirenli, Mehmet, Ayşen Taslak Şengül, Yasemin Büyükkarabacak, and Ahmet Başoğlu. “The Evaluation of the Affect of Seventh Staging System of Esophagus Cancers to the Prognosis and Survival”. Journal of Experimental and Clinical Medicine 41, no. 3 (September 2024): 626-35.
EndNote Pirzirenli M, Taslak Şengül A, Büyükkarabacak Y, Başoğlu A (September 1, 2024) The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival. Journal of Experimental and Clinical Medicine 41 3 626–635.
IEEE M. Pirzirenli, A. Taslak Şengül, Y. Büyükkarabacak, and A. Başoğlu, “The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival”, J. Exp. Clin. Med., vol. 41, no. 3, pp. 626–635, 2024.
ISNAD Pirzirenli, Mehmet et al. “The Evaluation of the Affect of Seventh Staging System of Esophagus Cancers to the Prognosis and Survival”. Journal of Experimental and Clinical Medicine 41/3 (September 2024), 626-635.
JAMA Pirzirenli M, Taslak Şengül A, Büyükkarabacak Y, Başoğlu A. The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival. J. Exp. Clin. Med. 2024;41:626–635.
MLA Pirzirenli, Mehmet et al. “The Evaluation of the Affect of Seventh Staging System of Esophagus Cancers to the Prognosis and Survival”. Journal of Experimental and Clinical Medicine, vol. 41, no. 3, 2024, pp. 626-35.
Vancouver Pirzirenli M, Taslak Şengül A, Büyükkarabacak Y, Başoğlu A. The evaluation of the affect of seventh staging system of esophagus cancers to the prognosis and survival. J. Exp. Clin. Med. 2024;41(3):626-35.