Electrocardiographic Findings in First-Episode Schizophrenia Patients: QT, QTc, P-Wave Dispersion, and Tp-e/QTc Ratio

Year 2024, Volume: 41 Issue: 4, 725 - 729, 31.12.2024

Figen Unal Demir , Eda Çetin , Bahadır Demir , Filiz Özsoy

Abstract

To investigate the electrocardiographic results of newly diagnosed first-episode schizophrenia patients compared with healthy controls. This study included 70 individuals (35 diagnosed with schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, criteria and 35 healthy controls). Resting supine electrocardiography (ECG) recordings were obtained for all of the participants and evaluated by the same cardiologist. The heart rate, P wave durations, QT interval, Tpeak-to-Tend (Tp-e) value, P wave dispersion (PWD), QT dispersion, and Tp-e dispersion were calculated. There were no statistically significant differences in the demographic data among the participants. The mean age of the patient group was 27.06 ± 7.53 years, while that of the control group was 26.77 ± 4.33 years (p > 0.05). The QT interval dispersion, PWD, Tp-e dispersion, and corrected QT (QTc) dispersion durations were higher in the patient group compared to the control group (p < 0.05). The minimum Tp-e value and Tp-e/QTc ratio were lower in the patient group. Considering the obtained data, it can be suggested that even at the time of initial diagnosis without prior treatment, patients with schizophrenia are at risk for cardiac arrhythmias and rhythm disorders. Therefore, it is recommended that physicians take potential cardiac conduction issues into account when evaluating these patients and initiating medical treatment.

Keywords

Schizophrenia, first-episode, electrocardiography, heart rate, QTc dispersion, P wave dispersion, Tp-e dispersion

Ethical Statement

Etik kurul onayı alınmıştır

Supporting Institution

yoktur

Thanks

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