Case Report
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Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report

Year 2025, Volume: 42 Issue: 1, 89 - 91, 28.03.2025

Abstract

Persistence of primitive intracranial embryonic anastomoses such as the permanent primitive trigeminal artery (PPTA) is rare, with the PPTA representing 80-85% of these cases. Aneurysms associated with PPTA are rare. This presents diagnostic and therapeutic challenges. We report a 64-year-old woman, initially evaluated for headache and dizziness, where cranial computed tomography (CT) incidentally suggested a hypodense sellar lesion. Subsequently, on CT angiography, a 9 mm saccular aneurysm in the PPTA and an 18 mm aneurysm in the right internal carotid artery (ICA) cavernous segment were identified. Endovascular treatment with flow diverter stent implantation was successfully performed, followed by post-operative ticagrelor and acetylsalicylic acid therapy. The patient was discharged neurologically intact after three days of care in the hospital and there was no deterioration in neurological examination at 1-year follow-up. This case underscores the necessity of careful angiographic evaluation in patients with suspected pituitary masses to avoid potentially catastrophic misdiagnoses. It also highlights the critical role of imaging techniques in identifying rare vascular anomalies.

Ethical Statement

Hastadan yazılı bilgilendirilmiş onam alınmıştır. Ege Üniversitesi Tıp Fakültesi Etik Kurulu olgu sunumları için etik kurul belgesi talep etmemektedir.

Supporting Institution

YOKTUR

Thanks

YOKTUR

References

  • 1. O’uchi E, O’uchi T. Persistent primitive trigeminal arteries (PTA) and its variant (PTAV): analysis of 103 cases detected in 16,415 cases of MRA over 3 years. Neuroradiology. 2010;52:1111-1119.
  • 2. Dimmick SJ, Faulder KC. Normal variants of the cerebral circulation at multidetector CT angiography. RadioGraphics. 2009;29:1027-1043.
  • 3. Suttner N, Mura J, Tedeschi H, Ferreira MA, Wen HT, de Oliveira E, et al . Persistent trigeminal artery: a unique anatomic specimen— analysis and therapeutic implications. Neurosurgery. 2000;47:428-434.
  • 4. Lam JJH, Mohamed Shah MT bin, Chung SL, Ho CL. Persistent primitive trigeminal artery associated with a cavernous carotid aneurysm. Case report and literature review. J Radiol Case Rep. 2018;12:1-11.
  • 5. Tungaria A, Kumar V, Garg P, Jaiswal AK, Behari S. Giant, thrombosed, sellar–suprasellar internal carotid artery aneurysm with persistent, primitive trigeminal artery causing hypopituitarism. Acta Neurochir. 2011;153:1129-1133.
  • 6. Azab W, Delashaw J, Mohammed M. Persistent primitive trigeminal artery: a review. Turk Neurosurg. 2024;22:399-406.
  • 7. Kai Y, Ohmori Y, Watanabew M, Morioka M, Hirano T, Kawano T, et al. Coil embolization of an aneurysm located at the trunk of the persistent primitive trigeminal artery -case report-. Neurol Med Chir (Tokyo). 2011;51:361-364.
  • 8. Takase T, Tanabe H, Kondo A, Nonoguchi N, Tane K. Surgically treated aneurysm of the trunk of the persistent primitive trigeminal artery-case report-. Neurol Med Chir (Tokyo). 2004;44:420-423.
  • 9. Baltsavias G, Valavanis A. Endovascular occlusion of a lacerated primitive trigeminal artery during surgical resection of clival chordoma. Interv Neuroradiol. 2010;16:204-207.
  • 10. Saltzman GF. Patent primitive trigeminal artery studied by cerebral angiography. Acta radiol. 1959;51:329-336.
  • 11. Wan Z, Meng H, Xu N, Liu T, Chen Z, Zhang Z, et al. Coil embolisation of multiple cerebral aneurysms with lateral type I persistent primitive trigeminal artery: a case report and literature review. Interv Neuroradiol. 2019;25:628-634.
  • 12. Schlamann M, Doerfler A, Schoch B, Forsting M, Wanke I. Balloon-assisted coil embolization of a posterior cerebral artery aneurysm via a persistent primitive trigeminal artery: Technical note. Neuroradiology. 2006; 48:931-4.
  • 13. Akiyama T, Imamura H, Shigeyasu M, Goto M, Fukumits R, Sunohara T, et al. PulseRider-assisted coil embolization for an unruptured internal carotid artery–persistent primitive trigeminal artery aneurysm. J Stroke Cerebrovasc Dis. 2023;32:106876.
  • 14. Salas E, Ziyal IM, Sekhar LN, Wright DC. Persistent trigeminal artery: an anatomic study. Neurosurgery. 1998;43:557-561.
  • 15. Clerici AM, Merlo P, Rognone F, Noce M, Rognone E, Bono G. Persistent trigeminal artery causing “double” neurovascular conflict. Headache. 2009;49:472-476.
  • 16. Alcalá-Cerra G, Tubbs Rs, Niño-Hernández L. Anatomical features and clinical relevance of a persistent trigeminal artery. Surg Neurol Int. 2012; 3:111.
  • 17. Huang W, Zhang Y, Zhuang Y, Shi Y, Feng Y. An anatomical study of persistent trigeminal artery detected by computed tomography angiography and magnetic resonance angiography: proposal for a modified classification and a novel basilar artery grading system. Surg Radiol Anat. 2023; 45:947-957.
Year 2025, Volume: 42 Issue: 1, 89 - 91, 28.03.2025

Abstract

References

  • 1. O’uchi E, O’uchi T. Persistent primitive trigeminal arteries (PTA) and its variant (PTAV): analysis of 103 cases detected in 16,415 cases of MRA over 3 years. Neuroradiology. 2010;52:1111-1119.
  • 2. Dimmick SJ, Faulder KC. Normal variants of the cerebral circulation at multidetector CT angiography. RadioGraphics. 2009;29:1027-1043.
  • 3. Suttner N, Mura J, Tedeschi H, Ferreira MA, Wen HT, de Oliveira E, et al . Persistent trigeminal artery: a unique anatomic specimen— analysis and therapeutic implications. Neurosurgery. 2000;47:428-434.
  • 4. Lam JJH, Mohamed Shah MT bin, Chung SL, Ho CL. Persistent primitive trigeminal artery associated with a cavernous carotid aneurysm. Case report and literature review. J Radiol Case Rep. 2018;12:1-11.
  • 5. Tungaria A, Kumar V, Garg P, Jaiswal AK, Behari S. Giant, thrombosed, sellar–suprasellar internal carotid artery aneurysm with persistent, primitive trigeminal artery causing hypopituitarism. Acta Neurochir. 2011;153:1129-1133.
  • 6. Azab W, Delashaw J, Mohammed M. Persistent primitive trigeminal artery: a review. Turk Neurosurg. 2024;22:399-406.
  • 7. Kai Y, Ohmori Y, Watanabew M, Morioka M, Hirano T, Kawano T, et al. Coil embolization of an aneurysm located at the trunk of the persistent primitive trigeminal artery -case report-. Neurol Med Chir (Tokyo). 2011;51:361-364.
  • 8. Takase T, Tanabe H, Kondo A, Nonoguchi N, Tane K. Surgically treated aneurysm of the trunk of the persistent primitive trigeminal artery-case report-. Neurol Med Chir (Tokyo). 2004;44:420-423.
  • 9. Baltsavias G, Valavanis A. Endovascular occlusion of a lacerated primitive trigeminal artery during surgical resection of clival chordoma. Interv Neuroradiol. 2010;16:204-207.
  • 10. Saltzman GF. Patent primitive trigeminal artery studied by cerebral angiography. Acta radiol. 1959;51:329-336.
  • 11. Wan Z, Meng H, Xu N, Liu T, Chen Z, Zhang Z, et al. Coil embolisation of multiple cerebral aneurysms with lateral type I persistent primitive trigeminal artery: a case report and literature review. Interv Neuroradiol. 2019;25:628-634.
  • 12. Schlamann M, Doerfler A, Schoch B, Forsting M, Wanke I. Balloon-assisted coil embolization of a posterior cerebral artery aneurysm via a persistent primitive trigeminal artery: Technical note. Neuroradiology. 2006; 48:931-4.
  • 13. Akiyama T, Imamura H, Shigeyasu M, Goto M, Fukumits R, Sunohara T, et al. PulseRider-assisted coil embolization for an unruptured internal carotid artery–persistent primitive trigeminal artery aneurysm. J Stroke Cerebrovasc Dis. 2023;32:106876.
  • 14. Salas E, Ziyal IM, Sekhar LN, Wright DC. Persistent trigeminal artery: an anatomic study. Neurosurgery. 1998;43:557-561.
  • 15. Clerici AM, Merlo P, Rognone F, Noce M, Rognone E, Bono G. Persistent trigeminal artery causing “double” neurovascular conflict. Headache. 2009;49:472-476.
  • 16. Alcalá-Cerra G, Tubbs Rs, Niño-Hernández L. Anatomical features and clinical relevance of a persistent trigeminal artery. Surg Neurol Int. 2012; 3:111.
  • 17. Huang W, Zhang Y, Zhuang Y, Shi Y, Feng Y. An anatomical study of persistent trigeminal artery detected by computed tomography angiography and magnetic resonance angiography: proposal for a modified classification and a novel basilar artery grading system. Surg Radiol Anat. 2023; 45:947-957.
There are 17 citations in total.

Details

Primary Language English
Subjects Brain and Nerve Surgery (Neurosurgery), Neurosciences (Other)
Journal Section Case Report
Authors

Anil Erol 0000-0002-6190-2732

Bilal Bahadır Akbulut 0000-0002-7983-5056

Celal Cinar 0000-0002-3237-9268

Mustafa Serdar Bölük 0000-0002-9406-4114

Taşkın Yurtseven 0000-0001-7982-8115

Hüseyin Biçeroğlu 0000-0003-2306-0826

Publication Date March 28, 2025
Submission Date November 9, 2024
Acceptance Date March 24, 2025
Published in Issue Year 2025 Volume: 42 Issue: 1

Cite

APA Erol, A., Akbulut, B. B., Cinar, C., Bölük, M. S., et al. (2025). Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report. Journal of Experimental and Clinical Medicine, 42(1), 89-91.
AMA Erol A, Akbulut BB, Cinar C, Bölük MS, Yurtseven T, Biçeroğlu H. Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report. J. Exp. Clin. Med. March 2025;42(1):89-91.
Chicago Erol, Anil, Bilal Bahadır Akbulut, Celal Cinar, Mustafa Serdar Bölük, Taşkın Yurtseven, and Hüseyin Biçeroğlu. “Endovascular Management of a Persistent Primitive Trigeminal Artery Aneurysm Initially Misdiagnosed As Pituitary Adenoma: A Case Report”. Journal of Experimental and Clinical Medicine 42, no. 1 (March 2025): 89-91.
EndNote Erol A, Akbulut BB, Cinar C, Bölük MS, Yurtseven T, Biçeroğlu H (March 1, 2025) Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report. Journal of Experimental and Clinical Medicine 42 1 89–91.
IEEE A. Erol, B. B. Akbulut, C. Cinar, M. S. Bölük, T. Yurtseven, and H. Biçeroğlu, “Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report”, J. Exp. Clin. Med., vol. 42, no. 1, pp. 89–91, 2025.
ISNAD Erol, Anil et al. “Endovascular Management of a Persistent Primitive Trigeminal Artery Aneurysm Initially Misdiagnosed As Pituitary Adenoma: A Case Report”. Journal of Experimental and Clinical Medicine 42/1 (March 2025), 89-91.
JAMA Erol A, Akbulut BB, Cinar C, Bölük MS, Yurtseven T, Biçeroğlu H. Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report. J. Exp. Clin. Med. 2025;42:89–91.
MLA Erol, Anil et al. “Endovascular Management of a Persistent Primitive Trigeminal Artery Aneurysm Initially Misdiagnosed As Pituitary Adenoma: A Case Report”. Journal of Experimental and Clinical Medicine, vol. 42, no. 1, 2025, pp. 89-91.
Vancouver Erol A, Akbulut BB, Cinar C, Bölük MS, Yurtseven T, Biçeroğlu H. Endovascular management of a persistent primitive trigeminal artery aneurysm initially misdiagnosed as pituitary adenoma: A case report. J. Exp. Clin. Med. 2025;42(1):89-91.