The evaluation of renal parenchyma with strain elastography in glomerülonephritis patients

Year 2019, , 114 - 118, 01.06.2019

Mehmet Beyazal , Hatice Beyazal Polat , Fatma Beyazal Çeliker Ekrem Kara , Arzu Turan , Mehmet Fatih İnecikli , Tuğba Eldeş

https://doi.org/10.21601/ortadogutipdergisi.393354

Abstract

Objective: Elastography is a new ultrasound-based technique
able to assess tissue elasticity. The aims of this study were to evaluate the renal
parenchyma with elastography in patients with glomerülonephritis and to determine
the association between strain index and patients’ laboratory parameters.

Material and Method: Twenty-three patients (13 men, 13 women; mean
age 41.67 ± 13.4 years) with glomerülonephritis and 20 sex and age-matched healthy
controls were enrolled in this study. Estimated glomerüler filtration rate (eGFR),
serum creatinine, spot urine protein, spot urine creatinine, spot urine protein/creatinine
ratio were recorded in patients with glomerülonephritis. Elastography examinations
of renal paranchyma were performed for all participants and the strain ratio values
were measured.

Results: The right and left strain index values were
significantly higher in patients with glomerülonephritis than in controls (right;
3.89±0.82 vs. 3.39±0.78 p=0.038, left; 3.94±0.69 vs. 3.24±0.81 p=0.003, respectively).
The strain index scores did not showed any significant correlation with eGFR, serum
creatinine, spot urine protein, spot urine creatinine, spot urine protein/creatinine
ratio (for all, p˃ 0.05).
On ROC curve analysis based on strain ratio values of the patient and control groups,
the cut-off value for the diagnosis of glomerülonefritis was 3.8, with a sensitivity
of 61.5% and a specificity of 85%.

Conclusions: Strain index of elastography can be used to
differentiate patients with glomerülonefritis from healthy individuals.

Keywords

Elastography, ultrasonography, strain index, glomerülar diseases

Glomerülonefritli hastalarda böbrek parankiminin gerinim elastografi ile değerlendirilmesi

Abstract

Amaç: Elastografi doku elastisitesini değerlendiren yeni
bir ultrasonografi tekniğidir. Bu çalışmanın amacı, glomerülonefritli hastalarda
böbrek parankimini elastografi ile değerlendirmek ve hastaların laboratuvar verileri
ile gerinim indeksi arasında ilişkiyi tespit etmektir.

Gereç ve Yöntem: Bu çalışmaya glomerülonefritli
26 hasta (13 erkek, 13 kadın, ortalama yaş; 41,67 ± 13,4) ile cinsiyet ve yaş eşleştirilmiş
20 sağlıklı kontrol grubu dahil edildi. Glomerülonefritli hastaların tahmini glomerül
filtrasyon hızı (eGFR), serum kreatinin, spot idrar proteini, spot idrar kreatinin,
spot idrar protein / kreatinin oranı kaydedildi. Tüm katılımcıların elastografi
ile böbrek parankim incelemeleri yapıldı ve gerinim indeksleri ölçüldü.

Bulgular: Glomerülonefritli hastalarda
sağ ve sol böbrek gerinim indeksleri kontrollerden daha yüksekti (sağ; 3,89 ± 0,82
ve 3,39 ± 0,78 p = 0,038, sol; 3,94 ± 0,69 ve 3,24 ± 0,81 p = 0,003). Hastaların
böbrek gerinim indeksleri ile tahmini glomerül filtrasyon hızı, serum kreatinin,
spot idrar protein, spot idrar kreatinin, spot idrar protein/kreatinin değerleri
ile anlamlı bir korelasyon saptanmadı (p˃ 0,05). Hasta ve kontrol gruplarının gerinim indekslerine
dayanan ROC eğrisi analizindeki incelemede glomerülonefrit tanısı için gerinim oranı
değerleri cut-off değeri 3,8, duyarlılık %61,5 ve özgüllük %85 idi.

Sonuç: Elastogram indeksleri glomerülonefritli hastaları
sağlıklı bireylerden ayırmak için kullanılabilir.

Keywords

gerinim indeksi, glomerüler hastalık, elastografi, ultrasonografi

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