Pfapa sendromunda yeni öngörücü parametreler: nötrofil lenfosit oranı ve trombosit lenfosit oranı

Year 2019, , 231 - 234, 01.09.2019

Serkan Kayabaşı , Fatih Gül

https://doi.org/10.21601/ortadogutipdergisi.456084

Abstract

Amaç: Bu çalışmada Pfapa sendromu tanısı konulan ya da Pfapa sendromu ön tanısıyla takip edilen hastalarda nötrofil lenfosit oranı (NLO) ve trombosit lenfosit oranı (TLO) değerleri arasındaki ilişki araştırıldı.
Gereç ve Yöntem: Çalışmaya Pfapa sendromu tanısı konulmuş ya da Pfapa sendromu ön tanısıyla takip edilen 30 hasta (Pf grup) (16 erkek, 14 kadın; ort. yaş 3,33; dağılım 1-21 yıl) ile 30 sağlıklı birey (15 erkek, 15 kadın; ort. yaş 4,01 yıl; dağılım 1-23 yıl) (kontrol grubu) dahil edildi. Pfapa ve kontrol grubunun NLO ve TLO değerleri hesaplandı ve istatistiksel olarak karşılaştırıldı.
Bulgular: Ortalama NLO değeri Pf grubunda 2,21, kontrol grubunda ise 1,75 idi ve bu farklılık istatistiksel olarak anlamlıydı (p=0,001). Ortalama TLO değeri Pf grubunda 120,76, kontrol grubunda ise 109,82 idi fakat bu farklılık istatistiksel olarak anlamlı değildi (p=0,073).
Sonuç: Pfapa sendromu tanısı konulan hastalarda kolay uygulanabilen ve düşük maliyetli testler ile elde edilen NLO değeri yeni bir belirteç olarak kullanılabilir. Trombosit lenfosit oranı değeri için ise daha geniş hasta serili yeni çalışmalara ihtiyaç vardır.

Keywords

PFAPA sendromu, nötrofil lenfosit oranı, trombosit lenfosit oranı

New predictive parameters of Pfapa syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Abstract

Objective: This study aims to investigate the correlations between Pfapa (Pf) syndrome or following with Pfapa syndrome diagnosed with neutrophil to lymphocyt ratio (NLR) and platelet to lymphocyte ratio (PLR).
Material and Method: The study included 30 patients (16 males, 14 females; mean age 3.33 years; range 1 to 21 years) diagnosed as Pfapa (Pf group) and 30 healthy individuals (15 males, 15 females; mean age 4.01 years; range 1 to 23 years) (control group). Neutrophil to lymphocyte and PLR ratio values of Pf and control groups were calculated and statistically compared.
Results: Mean NLR value was 2.21 in the Pf group and 1.75 in the control group with a statistically significant difference (p=0.001). Mean PLR value was 120.76 in the Pf group and 109.82 in the control group with a statistically insignificant difference (p=0.073).
Conclusion: Neutrophil to lymphocyte ratio value may be used as a novel marker that is easily administered in patients with Pfapa Syndrome and obtained with low-cost tests. New studies with larger patient series are needed for the value of PLR.

Keywords

Pfapa syndrome, neutrophil to lymphocyte ratio, platelet to lymphocyte ratio

References

• Caorsi R, Pelagatti MA, Federici S, Finetti M, Martini A, Gattorno M. Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Curr Opin Rhematol 2010; 22: 579-84.
• Padeh S, Stoffman N, Berkun Y. Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. Isr Med Assoc J. 2008; 10: 358-60.
• Thomas KT, Feder HM, Lawton AR, Edwards KM. Periodic fever syndrome in chıldren. J Pediatr 1999; 135: 15-21.
• Feder HM, Salazar JC. A clinical review of 105 patients with PFAPA (a periodic fever syndrome). ACTA Paediatr. 2010; 99: 178-84.
• Cantarini L, Vitale A, Bartolomei B, Galeazzi M, Rigante D. Diagnosis of PFAPAsyndrome applied to a cohort of 17 adults with unexplained recurrent fevers. Exp Rheumatol. 2012; 30: 269–71.
• Wang D, Yang JX, Cao DY, Wan XR, Feng FZ, Huang HF, ve ark. Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther 2013; 6: 211-6.
• Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, ve ark. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013; 11: 559.
• Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013; 34: 1400-4.
• Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F, ve ark. Neutrophil-to-lymphocyte ratio as a novelpotential marker for predicting prognosis of Bell palsy. Laryngoscope 2014; 124: 1678-81.
• Rudiger A, Burckhardt OA, Harpes P: The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med 2006, 24, 451–4.
• Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of allcause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis 2012; 34: 326-34.
• Atan D, Özcan KM, Köseoğlu S, İkincioğulları A, Çetin MA, Ensari S, Dere H. New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio Kulak Burun Bogaz Ihtis Derg 2015; 25(2): 97-101.
• Turkmen K. Platelet-to-Lymphocyte Ratio: One of the novel and valuable platelet indices in hemodialysis patients. Hemodial Int 2013; 17: 670.