Association of obesity with vitamin D, C-reactive protein, blood group and hemogram parameters

Year 2018, Volume: 10 Issue: 1, 20 - 25, 05.04.2018

Ahmet Nalbant Suat Konuk

https://doi.org/10.21601/ortadogutipdergisi.283272

Abstract

Objective: Obesity is one of the most important and growing
health problems of today. We aimed to search for possible association between
obesity and vitamin D as well as inflammatory and hemogram parameters.

Material and method: In this study 161 patients presented to internal
medicine outpatient clinic with an intention to enter a weight loss program for
obesity has been included. Patients were divided into obese and non obese
groups. Demographic and laboratory data were recorded.

Results: Mean age was 31±8 and 93% of
patients were women. Age, waist circumference, fat%, fat mass, free fat mass,
total body water and basal metabolic rate were significantly higher while high
density lipoprotein was significantly lower 
in obese patients. Similarly, fasting blood sugar, insulin resistance, C-reactive
protein (CRP) and blood pressure were significantly higher in the obese group.
Obesity and gender were not associated (Pearson Chi square test 0.455, p=0.500).
Vitamin D levels did not differ significantly between groups (Mann-Whitney U
test 2881, p=0.653). But there was significant association between vitamin D
and obesity when vitamin D status was categorized (Pearson Chi square test 5.575,
p=0.0189). There was no
significant difference in hemoglobin, neutrophil, neutrophil/ lymphocyte ratio  and platelet lymphocyte ratio  between obese and non obes groups. Obesity was not associated with blood groups
and Rh status.

Conclusion: Obesity and vitamin deficiency were associated. This
might be explained by vitamin D deficiency per se, or changes in vitamin D
metabolism in obese persons. Also increased CRP in obese it might show a
general inflammatory status in this group of patients.

Keywords

Obesity, vitamin D, c-reactive protein, hemogram, blood group

Obezite ile D vitamini, C-reaktif protein, hemogram parametreleri ve kan grupları arasındaki ilişki

Abstract

Amaç:
Obezite
günümüzde giderek artan en önemli sağlık sorunlarından biridir. Bu çalışmada,
obez hastaların vitamin D düzeyleri, C-reaktif protein (CRP), hemogram
parametreleri ve kan grupları ile  beden
kitle indeksi arasındaki ilişkiyi incelemek amaçlanmıştır.

Materyal
ve metod: Çalışmaya iç
hastalıkları polikliniğine kilo vermek için başvuran ve diyet yapmak
isteyen 161 kişi alındı. Hastalar beden kitle indeksine göre iki gruba ayrıldı.
Demografik ve laboratuvar verileri
hasta kayıtlarından elde edildi.

Bulgular: Çalışmaya alınan 161 olgunun yaş ortalaması 31±8, kadın olgu sayısı 150 (%93)
ve erkek olgu sayısı 11 (%7) idi. Obez olan bireyler obez olmayanlarla
karşılaştırıldığında yaş, bel çevresi, yağ, yağ kitlesi, yağsız vücut kitlesi, total
vücut suyu, bazal metabolizma hızı artmış iken yüksek dansiteli lipoprotein
düzeyleri anlamlı derecede düşüktü. Obez bireylerde obez olmayanlara göre açlık
kan şekeri, HbA1c, insülin direnci ve C-reaktif protein, sistolik ve diyastolik
tansiyon değerleri arasında  anlamlı fark
vardı.  Obezite ile cinsiyet arasında
ilişki yoktu (Pearson Chi square test 0.455, p=0.500). Obez olan ve olmayan gruplar
arasında D vitamin  düzeyleri bakımından
anlamlı fark yoktu (Mann-Whitney U test 2881, p=0.653). Ancak gruplar D
vitamini yeterli ve yetersiz diye kategorize edildiğinde D vitamini ile obezite
arasında istatiksel olarak anlamlı ilişki vardı (Pearson Chi square test 5.575,
p=0.0189). Obezite ile hemoglobin, nötrofil, lenfosit, nötrofil/lenfosit oranı ve
platelet lenfosit oranı bakımından anlamlı fark yoktu. Obezite
ile kan grupları  ve Rh bakımından
anlamlı ilişki yoktu.

Sonuç: D vitamini
yetersizliği ile obezite arasında anlamlı ilişki vardı. D vitamini yetersizliği
artmış
insülin direnci ile birlikte idi. Bu durum D vitamini yetersizliğinin kendisi
veya obezite
gelişim sürecinde D vitamin metabolizmasındaki farklılıklarla açıklanabilir.
Ayrıca CRP’nin artması  obez bireylerde
enflamasyonu göstermede yararlı bir marker olabilir.

Keywords

Obezite, D vitamini, hemogram, C-reaktif protein

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