Research Article
BibTex RIS Cite

The relationship between localization and neutrophil lymphocyte ratio in colon carcinoma

Year 2018, Volume: 10 Issue: 1, 64 - 67, 30.03.2018
https://doi.org/10.21601/ortadogutipdergisi.398756

Abstract

Objective:
We
aimed to compare the neutrophil lymphocyte ratio(NLR), which is a simple
method, to determine whether the difference between the right colon and the
left colon tumors in our study is related to the inflammatory process between
the two regions.

Material
and Method:
We retrospectively
reviewed the files of 142 patients who were diagnosed with stage 1-3 colorectal
cancer between July 2011 and June 2015 at Medical Oncology Department, Dışkapı
Yıldırım Beyazıt Education and Research Hospital. We examined whether tumor
localization correlates with neutrophil lymphocyte ratio (NLR) and disease-free
survival.

Results:
The
patients were divided into right and left colon based on splenic flexure. There
were 35 patients (24%) defined as right colon and 107 (76%) patients defined as
left colon. 85 (60%) of the patients were male and 57 (40%) were female. The
ratio of neutrophil and lymphocytes at diagnosis was compared. The mean NLR values
of the left and right colon were calculated as 4.43 and 5.05, respectively. No
statistically significant difference was found between the right and left colon
(p = 0.234). The disease-free survival rates were lower in the right colon
tumors than in the left colon, but not statistically significant (0,88 / 0,84
40th and 60th at 20th month) 0.80 / 0.77 and0,80/0,77; p = 0.064)

Conclusion:
In
our study, we could not find any relation between the NLR and the localization
of the disease in patients with early stage colorectal cancer. Disease-free
survival rates were calculated to be lower in right colon tumors, although they
did not reach statistical significance with respect to left colon.



References

  • 1.Ferlay, Jacques, et al. "Cancer incidence and mortalityworldwide: sources, methods and majör patterns in GLOBOCAN 2012." International journal of cancer 136.5 (2015): E359-E386.2. Danaei, Goodarz, et al. "Causes of cancer in theworld: comparative risk assessment of nine behavioural and environmental risk factors." The Lancet366.9499 (2005): 1784-1793.3.Johns, Louise E., and Richard S. Houlston. "A systematic reviewand meta-analysis of familial colorectal cancer risk." TheAmerican journal of gastroenterology 96.10 (2001): 2992-3003.4. Romolo J.L.Embriyoloji and anatomi of the colon Shackelford’s Surgery of the Alimentary Tract, 4:3-16, 19965. Hansen, Iben Onsberg, and Per Jess. "Possible better long-term survival in left versus right-sided colon cancer-a systematic review." Dan Med J 59.6 (2012): A4444.6.Benedix, F., et al. "Right-and left-sided colonic cancer-different tumour entities." Zentralblattfur Chirurgie 135.4 (2010): 312-317.7.Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70. 8.Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-6749.Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. BratislLekListy 2001; 102: 5-14.10.Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 73: 215-220.11.Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT, et al. Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 2009; 58: 15-2312.Ding, Pei-Rong, et al. "Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer." International journal of colorectal disease 25.12 (2010): 1427-1433.13Halazun KJ, Hardy KJ, Rana AA, Woodland DC, Luyten EJ, Mahadev S, et al. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. AnnSurg 2009; 250: 141-151.14Bertuzzo VR, Cescon M, Ravaioli M, Grazi GL, Ercolani G, Del Gaudio M, et al. Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers. Transplantation 2011; 91: 1279-1285.15Sato H, Tsubosa Y, Kawano T. Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer. World J Surg 2012; 36: 617-622.16Miyata H, Yamasaki M, Kurokawa Y, Takiguchi S, Nakajima K, Fujiwara Y, et al. Prognostic value of an inflammation-basedscore in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer. Exp Ther Med 2011; 2: 879-885.17.Keizman D, Ish-Shalom M, Huang P, et al. The association of pretreatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. Eur J Cancer 2012; 48(2): 202–8.18. Ding PR, An X, Zhang RX, Fang YJ, Li LR, Chen G, Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer. 2010 Dec;25(12):1427-33. doi: 10.1007/s00384-010-1052-0. Epub 2010 Sep 19.(Halazun KJ, Aldoori A, Malik HZ, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008;34:55-60)20.Siegel, Rebecca, Carol De Santis, and Ahmedin Jemal. "Colorectal cancer statistics, 2014." CA: a cancer journal for clinicians 64.2 (2014): 104-117.21.Lee, G. H., et al. "Is right-sided colon cancer different to left-sided colorectal cancer? – a systematic review." European Journal of Surgical Oncology (EJSO) 41.3 (2015): 300-308.22. Paski SC, Wightman R, Robert ME, Bernstein CN. The importance of recognizing increased cecal inflammation in health and avoiding the misdiagnosis of nonspecific colitis. Am J Gastroenterol 2007;102:2294–9.23. Lowichik A, Weinberg AG. A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod Pathol: an official journal of the United States and Canadian Academy of Pathology, Inc 1996; 9:110–4.24. Kirby JA, Bone M, Robertson H, Hudson M, Jones DE. The number of intraepithelial T cells decreases from ascending colontorectum. J Clin Pathol 2003; 56:158.25. Guastadisegni C, Colafranceschi M, Ottini L, Dogliotti E. Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data. Eur J Cancer 2010;46:2788–98.26. Dahlin AM, Palmqvist R, Henriksson ML, et al. The role of the Cp Gisland methylatorphenotype in colorectal cancer prognosis depends on microsatellite instability screening status. Clin Cancer Res: an official journal of the American Association for Cancer Research 2010; 16:1845–55.27. Phipps AI, Buchanan DD, Makar KW, et al. BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. Cancer Epidemiol Biomarkers Prev: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012;21:1792–8.

Kolon kanserinde lokalizasyon ile nötrofil lenfosit oranı arasındaki ilişki

Year 2018, Volume: 10 Issue: 1, 64 - 67, 30.03.2018
https://doi.org/10.21601/ortadogutipdergisi.398756

Abstract

Amaç:
Çalışmamızda sağ kolon ile sol kolon yerleşimli tümörler arasındaki farkın iki
bölge arasındaki inflamatuvar süreçle ilişkili olup olmadığını basit bir yöntem
olan nötrofil lenfosit oranına bakarak karşılaştırmayı amaçladık
.

Gereç
ve Yöntem:
Dışkapı Yıldırım Beyazıt Eğitim ve
Araştırma Hastanesi Tıbbi Onkoloji bölümüne Temmuz 2011-Haziran 2015 tarihleri
arasında başvuran evre 1-3 kolorektal kanser tanısı almış 142 hastanın
dosyalarını retrospektif olarak inceledik. 
Tümör lokalizasyonu ile nötrofil lenfosit oranı (NLO) ve hastalıksız sağ
kalım arasında ilişki olup olmadığını araştırdık.

Bulgular:
Hastalar splenik fleksura baz alınarak sağ ve sol kolon şeklinde ikiye ayrıldı.
Sağ kolon olarak tanımladığımız 35 (%24), sol kolon olarak tanımladığımız 107
(%76) hasta vardı. Hastaların 85’i (%60) erkek, 57’si (%40) kadındı. Tanı
anındaki NLO karşılaştırıldı. Sağ ve sol kolonun NLO ortalama değerleri
sırasıyla 4,43 ve 5,05 olarak hesaplandı. Sağ ve sol kolon arasında NLO
açısından istatiksel olarak anlamlı farklılık saptanmadı (p=0.234). Hastalıksız sağ kalım oranları sağ kolon tümörlerinde sol
kolona göre istatiksel anlamlılığa ulaşmasa da daha düşük olarak hesaplandı
(20.
ayda 0,88/0,84; 40. ve 60. ayda sırasıyla 0,80/0,77 ve 0,80/0,77; p =0,064).







Sonuçlar:
Yaptığımız çalışmada metastatik olmayan kolorektal kanserli hastalarda tanı
anında bakılan NLO ile hastalığın lokalizasyonu arasında ilişki bulamadık. Hastalıksız
sağ kalım oranlarını sağ kolon tümörlerinde sol kolona göre istatiksel
anlamlılığa ulaşmasa da daha düşük olarak hesapladık. 

References

  • 1.Ferlay, Jacques, et al. "Cancer incidence and mortalityworldwide: sources, methods and majör patterns in GLOBOCAN 2012." International journal of cancer 136.5 (2015): E359-E386.2. Danaei, Goodarz, et al. "Causes of cancer in theworld: comparative risk assessment of nine behavioural and environmental risk factors." The Lancet366.9499 (2005): 1784-1793.3.Johns, Louise E., and Richard S. Houlston. "A systematic reviewand meta-analysis of familial colorectal cancer risk." TheAmerican journal of gastroenterology 96.10 (2001): 2992-3003.4. Romolo J.L.Embriyoloji and anatomi of the colon Shackelford’s Surgery of the Alimentary Tract, 4:3-16, 19965. Hansen, Iben Onsberg, and Per Jess. "Possible better long-term survival in left versus right-sided colon cancer-a systematic review." Dan Med J 59.6 (2012): A4444.6.Benedix, F., et al. "Right-and left-sided colonic cancer-different tumour entities." Zentralblattfur Chirurgie 135.4 (2010): 312-317.7.Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57-70. 8.Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-6749.Zahorec R. Ratio of neutrophil to lymphocyte counts-rapid and simple parameter of systemic inflammation and stress in critically ill. BratislLekListy 2001; 102: 5-14.10.Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology 2007; 73: 215-220.11.Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT, et al. Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Immunother 2009; 58: 15-2312.Ding, Pei-Rong, et al. "Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer." International journal of colorectal disease 25.12 (2010): 1427-1433.13Halazun KJ, Hardy KJ, Rana AA, Woodland DC, Luyten EJ, Mahadev S, et al. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. AnnSurg 2009; 250: 141-151.14Bertuzzo VR, Cescon M, Ravaioli M, Grazi GL, Ercolani G, Del Gaudio M, et al. Analysis of factors affecting recurrence of hepatocellular carcinoma after liver transplantation with a special focus on inflammation markers. Transplantation 2011; 91: 1279-1285.15Sato H, Tsubosa Y, Kawano T. Correlation between the pretherapeutic neutrophil to lymphocyte ratio and the pathologic response to neoadjuvant chemotherapy in patients with advanced esophageal cancer. World J Surg 2012; 36: 617-622.16Miyata H, Yamasaki M, Kurokawa Y, Takiguchi S, Nakajima K, Fujiwara Y, et al. Prognostic value of an inflammation-basedscore in patients undergoing pre-operative chemotherapy followed by surgery for esophageal cancer. Exp Ther Med 2011; 2: 879-885.17.Keizman D, Ish-Shalom M, Huang P, et al. The association of pretreatment neutrophil to lymphocyte ratio with response rate, progression free survival and overall survival of patients treated with sunitinib for metastatic renal cell carcinoma. Eur J Cancer 2012; 48(2): 202–8.18. Ding PR, An X, Zhang RX, Fang YJ, Li LR, Chen G, Elevated preoperative neutrophil to lymphocyte ratio predicts risk of recurrence following curative resection for stage IIA colon cancer. 2010 Dec;25(12):1427-33. doi: 10.1007/s00384-010-1052-0. Epub 2010 Sep 19.(Halazun KJ, Aldoori A, Malik HZ, et al. Elevated preoperative neutrophil to lymphocyte ratio predicts survival following hepatic resection for colorectal liver metastases. Eur J Surg Oncol 2008;34:55-60)20.Siegel, Rebecca, Carol De Santis, and Ahmedin Jemal. "Colorectal cancer statistics, 2014." CA: a cancer journal for clinicians 64.2 (2014): 104-117.21.Lee, G. H., et al. "Is right-sided colon cancer different to left-sided colorectal cancer? – a systematic review." European Journal of Surgical Oncology (EJSO) 41.3 (2015): 300-308.22. Paski SC, Wightman R, Robert ME, Bernstein CN. The importance of recognizing increased cecal inflammation in health and avoiding the misdiagnosis of nonspecific colitis. Am J Gastroenterol 2007;102:2294–9.23. Lowichik A, Weinberg AG. A quantitative evaluation of mucosal eosinophils in the pediatric gastrointestinal tract. Mod Pathol: an official journal of the United States and Canadian Academy of Pathology, Inc 1996; 9:110–4.24. Kirby JA, Bone M, Robertson H, Hudson M, Jones DE. The number of intraepithelial T cells decreases from ascending colontorectum. J Clin Pathol 2003; 56:158.25. Guastadisegni C, Colafranceschi M, Ottini L, Dogliotti E. Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival data. Eur J Cancer 2010;46:2788–98.26. Dahlin AM, Palmqvist R, Henriksson ML, et al. The role of the Cp Gisland methylatorphenotype in colorectal cancer prognosis depends on microsatellite instability screening status. Clin Cancer Res: an official journal of the American Association for Cancer Research 2010; 16:1845–55.27. Phipps AI, Buchanan DD, Makar KW, et al. BRAF mutation status and survival after colorectal cancer diagnosis according to patient and tumor characteristics. Cancer Epidemiol Biomarkers Prev: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2012;21:1792–8.
There are 1 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original article
Authors

Sema Türker

Cengiz Karaçin This is me

G. İnanç İmamoğlu

Tülay Eren

Ramazan Esen

Ebru Çılbır

Mustafa Altınbaş

Özlem Aydın İsak This is me

Doğan Yazılıtaş

Publication Date March 30, 2018
Published in Issue Year 2018 Volume: 10 Issue: 1

Cite

Vancouver Türker S, Karaçin C, İmamoğlu Gİ, Eren T, Esen R, Çılbır E, Altınbaş M, İsak ÖA, Yazılıtaş D. Kolon kanserinde lokalizasyon ile nötrofil lenfosit oranı arasındaki ilişki. omj. 2018;10(1):64-7.

e-ISSN: 2548-0251

The content of this site is intended for health care professionals. All the published articles are distributed under the terms of

Creative Commons Attribution Licence,

which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.