Kırıkkale ilinde küçük hücre dışı akciğer kanseri tanılı hastaların retrospektif değerlendirilmesi

Year 2018, Volume: 10 Issue: 2, 103 - 109, 01.09.2018

Selim Yalçın

https://doi.org/10.21601/ortadogutipdergisi.335600

Abstract

Amaç:
Bu çalışmada kliniğimizde izlenen küçük hücre
dışı akciğer kanseri (KHDAK) hastalarının klinik ve epidemiyolojik
özellikleri, tedavileri, ortalama sağ kalımı,
sağ kalımı etkileyen faktörleri saptamayı amaçladık.

Gereç
ve Yöntem: Retrospektif
dizayndaki bu çalışmaya Kırıkkale Tıp Fakültesi İç Hastalıkları Anabilim
Dalı Tıbbi Onkoloji polikliniğine Ocak 2012-
Mayıs 2016 tarihleri arasında tanı ve tedavi
amacıyla başvuran 92  küçük hücre dışı akciğer kanseri
hastası dahil edildi.

Bulgular:
Hastaların 81’i erkek
(%88), 11’i kadın (%12), yaş ortalaması 65.3±8.99 idi (min:41, max:94).
Olguların %86,6 ’i aktif sigara içicisiydi.
Hastaların %94,5’inin başvuru
sırasında ECOG performans durumları 0 veya
1’di. Histolojik alt
gruplara göre hastaların 47
(%51,1)’i adenokarsinom,
39 (%42,4)’ü skuamöz hücreli
karsinom ve 6 (%6,5)’u diğer KHDAK’idi. Tümör tipleri ile lenfovasküler
invazyon varlığı karşılaştırıldığında adenokarsinomların %62,5’inde (n=5),
squamöz hücreli karsinomların %37,5’inde (n=3) lenfovasküler invazyonun olduğu
görülmüştür. Olguların %29,6’sında (n=8) lenfovasküler invazyon varken %70,4’ünde
(n=19) olmadığı görüldü. Lenfovasküler invazyon, ECOG performans durumu ve
kanser evresi sağ kalım üzerinde etkili bulunurken, yaş, cinsiyet,
komorbiditeler, sigara kullanımı, kanser tipi, kemoterapi ve beyin metastazları
sağ kalım üzerinde etkili değildi. Erkekler için ortanca sağ kalım 23,4 ay,
kadınlar için ise 18,1 aydı (p:0.633).

Sonuç:
Çalışmamızda kliniğimizde takip edilen küçük hücre dışı akciğer kanseri
hastalarının klinik, histolojik,  sağ
kalım özellikleri ve sağ kalım üzerinde etkili olan faktörler
değerlendirilmiştir.

Keywords

Küçük hücre dışı, akciğer kanseri, sağ kalım, histolojik tip, ECOG

Retrospective evaluation of non-small cell lung cancer patients in Kırıkkale

Abstract

Objective: 
In this study,
we aimed to determine the clinical
and  epidemiological features
of lung cancer patients, treatment modalities,  survival and factors affecting
survival in the patients who were followed up at our
clinic retrospectively.

Material and Method: Ninety two
non-small cell lung cancer patients
who were referred
to Kirikkale Faculty of
Medicine, Departmant of Medical Oncology Clinic between January 2012-May 2016
were included in the study.

Results: 
81 patients were male (88%) and 11 females (12%),that mean age was
65,3±8,99 years. 86.6% of the patients are actively smokers. At the time of diagnosis 94.5% of patients were
ECOG 0-1 performance status. For histopathologic subgroups, 47 (51.1%)
adenocarsinomo, 39 (42.4%) were squuamouscell carcinoma, 6 (6.5%) other NSCLC
subtypes. The
presence of lymphovascular invasion is compared with tumor types,
lymphovascular invasion have observed in 62.5% (n=5) of adenocarcinoma, 37.5%
(n=3) of squamous cell carcinoma. In the 29.6% (n=8) of the cases, there was
lymphovascular invasion but the lymphovascular invasion have not observed in
the majority of the patients (%70.4, n=19). Median
survival was 23.4 months in males, 18.1 months in women (p= 0.63). The
survival was effected by lymphovascular invasion, ECOG performance status and
cancer stage but not by age, sex, co-morbidity, smoking, cancer type, treating
with chemotherapy, existing brain metastasis.

Conclusions: In conclusion, our study evaluates clinical, histologic, survival
features and factors affecting survival
in non-small cell lung cancer patients who were followed up at
our clinic.

 

Keywords

Non-small cell, lung cancer, survival, histologic subtypes, ECOG

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