Endometrium kanserinde nötrofil/lenfosit oranının ve platelet endekslerinin değerlendirilmesi

Year 2018, Volume: 10 Issue: 3, 307 - 311, 30.09.2018

İlkin Yeral , Cemile Dayangan Sayan

https://doi.org/10.21601/ortadogutipdergisi.445159

Abstract

Amaç:
Jinekolojik kanserler arasında en sık görüleni endometrium
kanseridir. Tüm kanserlerde olduğu gibi, endometrium kanserinde de kronik
inflamasyon etyolojik faktör olarak rol oynamaktadır.

Gereç
ve Yöntem: Çalışmamıza her grupta 35 olmak üzere üç
grup ve toplam 105 hasta dahil edildi. Endometrial örnekleme sonuçlarına göre
gruplar; benign grup, hiperplazi grubu ve malign grup olarak isimlendirildi.
Gruplar arasında hematolojik parametrelerde anlamlı fark olup olmadığı
araştırıldı.

Bulgular:
Nötrofil sayısı, lenfosit sayısı, platelet sayısı, nötrofil/lenfosit
oranı ve platelet/lenfosit oranı bakımından gruplar arasında istatistiksel
olarak anlamlı bir fark saptanmadı (p>0,05). Hemoglobin, ortalama platelet
volümü ve Platelet dağılım genişliği değerleri malign grupta istatistiksel
olarak anlamlı derecede yüksek saptandı (p<0,05).

Sonuç: Çalışmamızda elde ettiğimiz sonuçlar bize; inflamasyonun,
platelet aktivitesini arttırarak endometrium kanserine zemin hazırlayabileceğini
düşündürdü.

Keywords

Endometrium kanseri, nötrofil/lenfosit oranı, ortalama platelet volümü

Evaluation of neutrophil / lymphocyte ratio and platelet indexes in endometrium cancer

Abstract

Aim:
Endometrium cancer is the most commonly seen
gynecologic cancer. As in all the cancer processes,
chronic inflammation plays an etiological role.

Material
and Method: The study included a total of 105 patients. Three
groups each
consisting 35 patients are formed. Based
on the results of endometrial sampling, the patients are groped as benign,
hyperplasia and malignant. Differences of
hematologic parameters between the groups were
investigated.

Results: There
was no statistically significant difference between the groups
in terms of neutrophil, lymphocyte, and platelet count,
neutrophil/lymphocyte ratio and
platelet/lymphocyte ratio (p>0.05).
Hemoglobin, mean platelet volume and platelet distribution width values ​​were
found statistically significantly higher in the malignant group (p<0.05).

Conclusion: As a result; inflammation may increase platelet
activity and provide a basis for endometrial cancer.

Keywords

Endometrium cancer, neutrophil/lymphocyte ratio, mean platelet volume, platelet distribution width

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