Oral kavitede görülen invaziv kanserler / Invasıve cancers of the oral cavıty

Year 2018, Volume: 10 Issue: 4, 523 - 529, 01.12.2018

Hümeyra Yazar , İnci Rana Karaca

https://doi.org/10.21601/ortadogutipdergisi.334990

Abstract

Ağız kanseri, dünyada en sık görülen 6. kanser olup, tüm dünyada kanserle ilişkili ölümlerde erkekler arasında 20. sırada, kadınlar arasında ise 16. sırada yer almaktadır. Tüm ağız boşluğu kanserlerinin %90'ından fazlası oral skuamöz hücreli karsinomdur. Oral kanser orta yaşlı bireylerde sık görülmektedir. İnsidans yaşla birlikte artmaktadır. Ağız kanseri genellikle asemptomatiktir. İlk belirtileri kızarık alanlar, küçük mukozal büyümeler veya ülserasyonlar şeklinde olmaktadır. İleri evrede tümör kas, kemik veya cilt gibi komşu dokulara infiltre olmakta ve bölgesel lenf nodlarına yayılım göstermektedir. Bölgesel lenf nodu metastazı prognozu kötüleştirmektedir. Bu derlemede, skuamöz hücreli karsinom ile verrüköz karsinom, malign melanom, primer intraosseöz skuamöz hücreli karsinom gibi ağız kavitesinde görülen diğer invaziv kanserler ve tedavileri ile ilgili bilgi vermeyi amaçladık.

Keywords

ağız kanseri, skuamöz hücreli karsinom, malignansi, invaziv kanserler

Invasive cancers of the oral cavity: review

Abstract

Oral cancer is the sixth most common cancer worldwide. Globally, therefore, ‘oral cancer’ is the twelfth most frequent cause of cancer related deaths amongst males and sixteenth amongst females. Oral cancer is common in middle-aged adults. Incidence increases with age. More than 90% of oral malignancies are oral squamous cell carcinoma. Oral cancer is asymptomatic in general. Early mucosal lesions seem as reddish areas, small mucosal growths or ulcerations. In late stage, tumor infiltrates to contiguous tissues such as muscle, bone or skin and evolves to regional lymph nodes. Metastasis to regional lymph nodes considered as poor prognosis. In this review, we aimed to give information about squamous cell carcinoma and other invasive cancers of oral cavity such as verrucous carcinoma, malign melanoma, primary intraosseous squamous cell carcinoma and their treatments.  

Keywords

Oral cancer, squamous cell carcinoma, malignancy, invasive cancers, verrucous carcinom

References

• WHO. Available from: http://www.who.int/cancer/en/. 2017
• Johnson NW, Warnakulasuriya S, Gupta P, Dimba E, Chindia M, Otoh E. Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions. Advances Dent Res. 2011;23(2):237-46.
• Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):359-386
• Johnson NW, Gupta B, Ariyawardana A, Amarasinghe H. Epidemiology and Site-Specific Risk Factors for Oral Cancer. Contemporary Oral Oncology: Springer; 2017; 103-53.
• Institute: NC. Surveillance Epidemiology and End Results (SEER). SEER cancer statistics review 1975–2004. Available from: http://seer.cancer.gov/statfacts/html/oralcav.html ./ 2017
• Soler M, Bosetti C, Franceschi S, Negri E, Zambon P, Talamini R. Fiber intake and the risk of oral, pharyngeal and esophageal cancer. Int J Cancer. 2001;91(3):283-7.
• World Health Organization IARC, Oral Atlas. Available from: http://screening.iarc.fr/atlasoral_list.php?cat=B&lang=1./2017
• Oreggia F, de Stefani E, Correa P, Fierro L. Risk factors for cancer of the tongue in Uruguay. Cancer. 1991;67(1):180-3.
• Lwellyn C, Johnson N, Warnakulasuriya K. Risk factors for squamous cell carcinoma of the oral cavity in young people—a comprehensive literature review. Oral Oncol. 2001;37(5):401-18.
• The Oral cancer Foundation. Available from: http://oralcancerfoundation.org/cdc/risk- factors/ 2017
• Barnes L, Eveson J, Reichart P, Sidransky D. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Word Health Organization Classification of Tumours: Pathology and genetics of head and neck tumors. 2005.
• Yücetaş Ş. Ağız ve çevre dokusu hastalıkları: Atlas Kitapçılık; 2005.
• Ömer. G. Oral ve Maksillofasiyal Patoloji. Ömer G, editor. Ankara:: Qintessence Publishing; 2015.
• Pignon J-P, Le Maitre A, Bourhis J. Meta-analyses of chemotherapy in head and neck cancer (MACH-NC): an update. Int J Rad Oncol Biol Physics. 2007;69(2):112-114.
• Pindborg JJ, Reichart P, Smith C, Van der Waal I. Histological Typing of Cancer and Precancer of the Oral Mucosa: In Collaboration with LH Sobin and Pathologists in 9 Countries: Springer Science & Business Media; 2012.
• Ananthaneni A, Ponnapalli H, Kiresur MA, Chaitanya SK. Mucoepidermoid carcinoma involving the palate with lamellated calcifications: A notable finding. Europe J Gen Dent. 2016;5(1):35-38
• Prasad ML, Patel S, Hoshaw-Woodard S, Escrig M, Shah JP, Huvos AG. Prognostic factors for malignant melanoma of the squamous mucosa of the head and neck. Am J Surg Pathol. 2002;26(7):883-92.
• Naik NP, Kiran AR, Samata Y, Kumar AV. Deadliest tumor of oral cavity: A rare case of intra oral malignant melanoma. Journal of Oral Research and Review. 2014;6(2):49-52
• Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science-AAAS- Weekly Paper Edition. 1994;266(5192):1865-9.
• Oncology Nurse Adviser. Available from: http://www.oncologynurseadvisor.com/kaposi-sarcoma-of- the-mouth/slideshow/952/ 2017
• Metgud R, Rai BA, Bulgannawar BA, Gupta K. Primary intraosseous squamous cell carcinoma arising from keratocystic odontogenic tumor: CK 17 evaluation. J Dr NTR Uni Health Sciences. 2015;4(4):275-279
• Thomas G, Pandey M, Mathew A, Abraham E, Francis A, Somanathan T. Primary intraosseous carcinoma of the jaw: pooled analysis of world literature and report of two new cases. Int J Oral Maxillofac Surg. 2001;30(4):349-55.
• Regezi JA, Sciubba JJ, Jordan RC. Oral Pathology-- -clinical Pathologic Correlations. Journal der Deutschen Dermatologischen Gesellschaft. 2008;6(7):607.
• Patel SG, Meyers P, Huvos AG, Wolden S, Singh B, Shaha AR. Improved outcomes in patients with osteogenic sarcoma of the head and neck. Cancer. 2002;95(7):1495-503.
• Castellarin P, Pozzato G, Tirelli G, Di Lenarda R, Biasotto M. Oral lesions and lymphoproliferative disorders. J Oncol. 2010;1-10.
• Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity–pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.
• Murakami K, Yamamoto K, Aoki K, Fukumoto I, Sugiura T, Kirita T. Metastatic sarcomatoid renal cell carcinoma to the mandible treated with Sorafenib. Open J Stomatol. 2012;2(03):222-227
• Hirshberg A, Buchner A. Metastatic tumours to the oral region. An overview. European J Cancer Part B: Oral Oncol. 1995;31(6):355-60.
• Sadık E, Alkurt MT. Oral mukozanın şüpheli lezyonlarının teşhisinde kullanılan yardımcı yöntemler. Acta Odontologica Turcica. 2012;29(3):201-208.
• Lestón JS, Dios PD. Diagnostic clinical aids in oral cancer. Oral Oncol. 2010;46(6):418-22.