Rare squamous cell carcinoma variants of the larynx: 7 years experience of one center

Year 2018, Volume: 10 Issue: 4, 476 - 482, 01.12.2018

Deniz Arık , Evrim Yılmaz Funda Canaz Özgür Pınarbaşlı , Melek Kezban Gürbüz Mustafa Fuat Açıkalın

https://doi.org/10.21601/ortadogutipdergisi.371912

Abstract

Squamous
cell carcinoma is the most common malignant epithelial tumor of the larynx. It
is mostly seen in males in 6th and 7th decades. In recent years the incidence
has increased in women due to increased use of tobacco and alcohol. Squamous
cell carcinoma is more common in supraglottic and glottic regions. The World
Health Organization has identified different subtypes of squamous cell
carcinoma. Some of these variants has better, some has worse prognosis that
than conventional squamous cell carcinoma. We present rare variants of squamous
cell carcinoma in our study.

Material and Method: All laryngeal biopsies were scanned at the Pathology Department of Eskişehir Osmangazi University during the last 7 years. The cases that were diagnosed as squamous cell carcinoma variants were included in the study. Patients’ histopathological and clinical parameters were recorded.

Results: There were 1148
laryngeal biopsies in the seven years period. Squamous cell carcinoma was
detected in 460 cases. Of these, 31 were rare squamous cell carcinoma variants.
These include 3 verrucous carcinomas, 6 basaloid, 11 papillary, 4 spindle cell,
6 acantholytic variant squamous cell carcinomas. Only one case was adenosquamous
carcinoma. Verrucous carcinomas were located on the vocal cord. The basaloid
variant was detected in supraglottic region in all cases. In other variants,
the glottic and supraglottic regions were affected at varying rates.
Infraglottic tumor was seen in only one of the cases. This case was
acantholytic variant squamous cell carcinoma.

Conclusion: Biological behaviors of rare variants of
laryngeal squamous cell carcinoma differ. These tumors can be treated
effectively with a multidisciplinary approach. Recognition and description of
these subtypes are necessary to determine the appropriate treatment.

Keywords

Larynx, squamous cell carcinoma, rare variants

Larinksin az görülen skuamöz hücreli karsinom varyantları: tek merkeze ait 7 yıllık deneyim

Abstract

Larinksin malign epitelyal tümörleri arasında skuamöz hücreli karsinom en sık görülendir. Daha çok erkeklerde, 6. ve 7.
dekadlarda görülür.
Son yıllarda tütün ve alkol kullanımının artması nedeniyle kadınlarda da
insidansının yükseldiği bildirilmektedir. Skuamöz hücreli karsinom supraglottik
ve glottik bölgede
daha sık görülür.
Dünya Sağlık Örgütü, skuamöz
hücreli karsinomun farklı alt tiplerini tanımlamıştır. Bu varyantlardan
bazıları konvansiyonel skuamöz
hücreli karsinoma göre
daha iyi, bazıları ise daha kötü
prognozludur. Çalışmamızda skuamöz
hücreli karsinomun az görülen
varyantları sunulmaktadır.

Gereç ve Yöntem: … Tıp Fakültesi Patoloji Anabilim
Dalı’nda son 7 yıllık dönemde
tüm larinks biyopsileri taranmıştır. Skuamöz hücreli karsinom varyantları şeklinde
tanı alan hastalar belirlenmiş, olguların histopatolojik ve klinik özellikleri derlenmiştir.

Bulgular: Yedi yıllık dönemde larinks biyopsisi yapılan
1148 olgu bulunmaktadır. Bu olgulardan 460’ı skuamöz hücreli karsinom tanısı
almıştır. Bunlardan 31’i nadir görülen
skuamöz
hücreli karsinom varyantıdır. Bunlar arasında 3 verrüköz karsinom, 6 bazaloid, 11
papiller, 4 iğsi hücreli,
6 akantolitik varyant skuamöz
hücreli karsinom olgusu mevcuttur. Bir olgu ise adenoskuamöz karsinom tanılıdır. Verrüköz karsinom olgularında tümör vokal kord yerleşimlidir.
Bazaloid varyant ise olguların tümünde supraglottik bölgede saptanmıştır. Diğer
varyantlarda glottik ve supraglottik bölge değişen oranlarda tutulmaktadır. Olguların
sadece birinde infraglottik tümör
mevcuttur. Bu olgu akantolitik varyant skuamöz hücreli karsinom olarak
değerlendirilmiştir.

Sonuç: Larinksin skuamöz hücreli karsinomunun az görülen varyantlarının biyolojik
davranışları farklılıklar göstermektedir.
Bu tümörler
multidisipliner yaklaşım ile efektif şekilde tedavi edilebilir. Alt tiplerin
tanınması ve tariflenmesi uygun tedavi yaklaşımının belirlenebilmesi için gereklidir.

Keywords

Larinks, skuamöz hücreli karsinom, nadir varyantlar

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