Neuropathic pain adversely affects functional status, quality of life and depression in patients with knee osteoarthritis

Year 2019, Volume: 11 Issue: 1, 15 - 21, 31.03.2019

Burhan Fatih Koçyiğit , Tuba Tülay Koca

https://doi.org/10.21601/ortadogutipdergisi.435075

Abstract

Aim:
The aim of our study was to determine the existence of neuropathic pain (NP) in
knee OA and its association with risk factors, functional status, quality of
life, and depression.

Material
and Methods: This was a descriptive study. A
total of 100 patients (90 female, 10
male) with knee OA were enrolled. Data including age, gender, educational
status, working status, body mass index, and symptom duration were obtained
from patients. Patients
were divided into three groups according to the PainDETECT scores: likely NP,
possible NP, unlikely NP. Patients'
pain severity was assessed using visual analogue scale (VAS). For the presence
of NP, PainDETECT scale was used. Functional status was evaluated by Western
Ontario and McMaster University Osteoarthritis Index (WOMAC). Quality of life
was assessed using Short Form-36 questionnaire (SF-36) and depression level was
evaluated using Hamilton Depression Scale (HAM-D). Kellgren-Lawrence grading
system was used to determine the radiologic severity. Pain,
functional status, quality of life and depression were compared among the
groups.

Results: Of the total, 18 patients (18%) were
in the likely NP group; 23 patients (23%) were in the possible NP group and 59
(59%) patients were in the unlikely NP group. No
significant differences were detected between the groups in sociodemographic
data (p > 0.05). Significant differences were detected in symptom duration, VAS,
WOMAC, SF-36 physical functioning subscale, physical role functioning subscale,
social role functioning subscale, vitality subscale, bodily pain subscale,
general health perceptions subscale and HAM-D scores among the groups (p <
0.05). PainDETECT scores were significantly correlated with VAS, WOMAC, SF-36
subscales, and HAM-D (p < 0.05).

Conclusion:
This study revealed that NP is associated with severe pain, reduced
functionality, impairment in quality of life, and higher depression scores in
patients with knee OA. 

Keywords

knee osteoarthritis, neuropathic pain, functional status, quality of life, depression

Nöropatik ağrı diz osteoartritli hastalarda fonksiyonel durumu, yaşam kalitesini ve depresyonu olumsuz etkiler

Abstract

Amaç:
Çalışmamızın amacı, diz OA'da nöropatik ağrı (NA) varlığını ve risk faktörleri,
fonksiyonel durum, yaşam kalitesi ve depresyon ile ilişkisini belirlemektir.

Gereç
ve Yöntemler: Bu tanımlayıcı bir çalışmadır. Diz
OA’i tanılı toplam 100 hasta (90 kadın, 10 erkek) çalışmaya alındı. Hastalardan
yaş, cinsiyet, eğitim durumu, çalışma durumu, vücut kütle indeksi ve semptom
süresini içeren veriler elde edildi. PainDETECT skorlarına göre hastalar üç
gruba ayrıldı: pozitif NA, muhtemel NA, negatif NA. Hastaların ağrı şiddeti görsel
analog skala (GAS) ile değerlendirildi. NA varlığı için PainDETECT ölçeği
kullanıldı. Fonksiyonel durum  Western
Ontario ve McMaster Üniversitesi Osteoartrit İndeksi (WOMAC) ile
değerlendirildi. Yaşam kalitesi Kısa Form-36 anketi (KF-36), depresyon düzeyi
Hamilton Depresyon Skalası (HAM-D) kullanılarak değerlendirildi. Radyolojik
değerlendirme için Kellgren-Lawrence evreleme sistemi kullanıldı. Gruplar
arasında ağrı, fonksiyonel durum, yaşam kalitesi ve depresyon karşılaştırıldı.

Bulgular:
Toplam 18 hasta (%18) pozitif NA grubunda, 23 hasta (%23) muhtemel NA grubunda,
59 hasta negatif NA grubundaydı. Sosyodemografik verilerde gruplar arasında
anlamlı fark saptanmadı (p > 0.05). Semptom süresi, GAS, WOMAC, KF-36
fiziksel fonksiyon alt ölçeği, fiziksel rol işleyişi alt ölçeği, sosyal
fonksiyon alt ölçeği, canlılık alt ölçeği, ağrı alt ölçeği, genel sağlık durumu
alt ölçeği ve HAM-D skorları arasında gruplar arasında anlamlı fark bulundu (p <
0.05). PainDETECT skorları GAS, WOMAC, KF-36 alt ölçekleri ve HAM-D ile anlamlı
olarak koreleydi (p < 0.05).

Sonuç:
Bu çalışma diz OA hastalarında NA'nın şiddetli ağrı, azalmış işlevsellik, yaşam
kalitesinde bozulma ve daha yüksek depresyon skorları ile ilişkili olduğunu
ortaya koymuştur. 

Keywords

diz osteoartriti, nöropatik ağrı, fonksiyonel durum, yaşam kalitesi, depresyon

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