Laringeal nöroendokrin karsinom

Year 2019, Volume: 11 Issue: 3, 353 - 357, 01.09.2019

Süleyman Emre Karakurt , Şeyda Akbal Nurcan Kum Aykut İkincioğulları Ayşe Yılmaz Çiftçi Hacı Hüseyin Dere

https://doi.org/10.21601/ortadogutipdergisi.467806

Abstract

Laringeal nöroendokrin karsinomlar larenksin nadir görülen tümörleridir. Ellidokuz yaşında erkek hasta 5 ay önce başlayan ses kısıklığı, ağrılı yutma ve kilo kaybı şikayeti ile kliniğimize başvurdu. Endoskopik muayenede sol ariepiglottik folddan, sol bant ventrikül ve ventriküle uzanımı olan kitle tespit edildi. Görüntüleme yöntemlerini takiben, hastaya direkt laringoskopi yapıldı ve biyopsi alındı. Biyopsi sonucu orta derecede diferansiye nöroendokrin karsinom olarak raporlandı. Hastanın cerrahi tedaviyi kabul etmemesi üzerine, hastaya eşzamanlı radyokemoterapi planlandı. Tedavi sonrası yedinci ayında hastanın kitlesinde belirgin regresyon gözlendi. Orta derecede diferansiye nöroendokrin karsinomda ilk tedavi seçeneği cerrahi olmak ile birlikte vakamızda, tümörün eş zamanlı radyokemoterapi tedavisine cevap verdiği gözlendi.

Keywords

nöroendokrin tümörler, karsinoid tümör, laringeal kanser

Laryngeal neuroendocrine carcinoma

Abstract

Laryngeal neuroendocrine carcinomas are rare tumors of the larynx. A fifty-nine-year-old patient was admitted to our clinic with dysphonia, painful swallowing and weight loss that have been going on for 5 months. Endoscopic examination revealed a mass which extended from left aryepiglottic fold to left ventricle and ventricular fold. Following imaging studies, the patient has undergone direct laryngoscopy and biopsy has been taken. The biopsy was reported as moderately differentiated neuroendocrine carcinoma. After the patient’s refusal of surgical treatment, concomitant radiochemotherapy was performed. Significant regression has been observed in the mass at the seventh month after the treatment. While the first option of treatment is surgical treatment in laryngeal neuroendocrine carcinoma, our case has been observed to respond to concomitant radiochemotherapy.

Keywords

neuroendocrine tumors, carcinoid tumor, laryngeal cancer

References

• Zhu Y, Gao L, Meng Y, ve ark. Laryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 Cases. Biomed ResInt 2015; 2015: 832194.
• Ferlito A, Silver CE, Bradford CR, Rinaldo A. Neuroendocrine neoplasms of the larynx: an overview. Head Neck 2009; 31: 1634-46.
• Lin HW, Bhattacharyya N. Staging and survival analysis for nonsquamouscell carcinomas of thelarynx. Laryngoscope 2008; 118: 1003-13.
• Barnes L. Neuroendocrine tumours. In: Barnes L, Eveson J, Reichart P, Sidransky DE, (eds).World Health Organization Classification of Tumours: Pathologyand Genetics of Head and NeckTumours. Lyon: IARC Press; 2005: 135-9.
• Kunz PL. Carcinoid and neuroendocrine tumors: building on success. J Clin Oncol 2015; 33: 1855-63.
• Lewis JS Jr, Ferlito A, Gnepp DR, ve ark. Terminology and classification of neuroendocrine neoplasms of thelarynx. Laryngoscope 2011; 121: 1187-93.
• Deep NL, Ekbom DC, Hinni ML, Zarka MA, Patel SH. High-Grade Neuroendocrine Carcinoma of the Larynx: The Mayo Clinic Experience. Ann Otol Rhinol Laryngol 2016; 125: 464-9.
• Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas 2010; 39: 707-12.
• Wick MR. The Mediastinum. Sternberg’s Diagnostic Surgical Pathology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2004: 1290-2.
• Zhang M, Zhou L, Li C, Huang WT, Li XM. Moderately differentiated neuroendocrine carcinoma of the larynx. Acta Otolaryngol 2010; 130: 498-502.
• Mikic A, Zvrko E, Trivic A, Stefanovic D, Golubovic M. Small cell neuroendocrine tumor of the larynx--a small case series. Coll Antropol 2012; 36: 201-4.
• Caric T, Bilic M, Bilic LK, ve ark. Neuroendocrine tumors of larynx—two case reports and literature review. Coll Antropol 2012; 36: 173-8.
• Ferlito A, Devaney KO, Rinaldo A. Neuroendocrine neoplasms of thelarynx: advances in identification, understanding, and management. Oral Oncol 2006; 42: 770-88.
• Ferlito A, Rinaldo A. Primary and secondary small cell neuroendocrine carcinoma of the larynx: a review. Head Neck 2008; 30: 518-24.
• van der Laan TP, Plaat BE, van der Laan BF, Halmos GB. Clinical recommendations on the treatment of neuroendocrine carcinoma of the larynx: A meta-analysis of 436 reported cases. HeadNeck 2015; 37: 707-15.