Behçet hastalarında QT dispersiyonunun biyokimyasal parametreler ile ilişkisi

Year 2019, Volume: 11 Issue: 4, 372 - 377, 01.12.2019

Emine Altuntaş , Hülya Nazik , Feride Çoban Gül Betül Demir

https://doi.org/10.21601/ortadogutipdergisi.474956

Abstract

Amaç: Multisistemik vaskülit ile karakterize olan Behçet Hastalığı’nda (BH) ventriküler aritmi ve ani kardiyak ölüm sıklığı normal popülasyona göre daha sık olması nedeni ile bu çalışmada QT dispersiyonu (QTd) ile BH ve hastalık ile ilişkili biyokimyasal parametreler arasındaki ilişkinin ortaya konulması amaçlanmıştır.
Materyal ve metot: Çalışmaya uluslararası sınıflandırma kriterlerine uygun olarak BH tanısı konulmuş 35 hasta ile yaş ve cinsiyet açısından benzer 47 sağlıklı kontrol olgu dahil edildi. Tüm katılımcıların 12 derivasyonlu yüzey EKG’si çekilerek kalp hızı ve QT mesafeleri ölçüldü. Ardından düzeltilmiş QT (QTc) Bazzet formülü ile hesaplandı. Tüm derivasyonlardaki en küçük QT ve QTc mesafesi ile en büyük QT ve QTc mesafesi arasındaki fark alınarak QTd, QTcd hesaplandı.12 saatlik açlık sonrası kan testleri yapılarak kaydedildi.
Bulgular: Gruplar en uzun QT ve QTc, en kısa QT ve QTc, QTd, QTcd değerleri açısından karşılaştırıldı. En uzun QT ve QTc’ de istatistiksel olarak fark oluştuğu görüldü (p=0,004, 0,018). Eritrosit sedimantasyon hızı (ESH) Behçet’li grupta kontrol grubuna göre yüksek iken; MPV ve albumin kontrol grubunda daha yüksek ölçüldü ve gruplar arasında anlamlı fark oluştu (p=0,002; 0,000; 0,000). Ayrıca en uzun QT ve QTc ile ESH ve albumin arasında negatif korelasyon olduğu; ortalama trombosit hacmi (MPV) ile pozitif korelasyon olduğu saptandı. İstatistiksel veriler Tablo 2-3-4‘te sunuldu.
Sonuç: Bu çalışmada BH’de en uzun QT ve QTc’nin uzadığı ve hastalık ile ilişkili diğer biyokimyasal parametrelerle arasında korelasyon olduğu tespit edilmiştir.

Keywords

Behçet Hastalığı, QT mesafesi, aritmi

Relationship between QT dispersion and biochemical parameters in Behçet’s disease

Abstract

Objective: Ventricular arrhythmia and sudden cardiac death are more frequently in Behçet’s disease (BD) patients than normal population. Therefore in this study it was aimed to find out relationship among QT dispersion, Behçet’s disease and biochemical parameters related with disease.
Material and Method: The study consisted of 35 patients which diagnosed Behçet’s disease (BD) according to international diagnose criteria and 47 healthy controls which were matched with regard to age and gender. 12-channel surface electrocardiography (ECG) was performed to all participants. QT distances, corrected QT (QTc) distances which is calculated by using Bazett formula were calculated. The longest QT, and the shortest QT, the longest QTc, the shortest QTc were found in the ECG. Afterwards QTd and QTcd were calculated. Blood samples were taken from participants after 12 hours fasting.
Findings: The groups were compared in terms of the longest QT-QTc, the shortest QT-QTc, QTd, QTcd. It was seen that there was meaningful difference in terms of the longest QT and QTc (respectively p; 0.004; 0.018). Mean platelet volume (MPV) and albumin were higher in control group while erythrocyte sedimentation rate (ESR) was higher in BH group (respectively p; 0.000; 0,000; 0,002).  Additionally there was negative correlation among the longest QT-QTc and ESR, albumin, but there was established positive correlation between the longest QT -QTc and MPV.  Statistical results were presented in table 2-3-4.
Conclusion: Consequently in this study, it was established that the longest QT and QTc was increased and there was relationship between biochemical parameters and the longest QT-QTc.

Keywords

Behçet’s disease, QT distance, arrhythmia

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