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The demographic and clinicopathological features of salivary gland tumors in Turkey

Year 2019, Volume: 11 Issue: 4, 450 - 455, 01.12.2019
https://doi.org/10.21601/ortadogutipdergisi.528284

Abstract

Aim: Salivary gland tumors (SGTs) are rare neoplasms thus, the local records are valuable to obtain the epidemiological overview. This study aimed to determine the demographic and clinicopathological features of SGTs in our clinic and compare the findings with the studies from Turkey and all over the world.
Material and methods: The data of 185 patients who underwent surgery for SGT in The Department of Otorhinolaryngology-Head and Neck Surgery of a tertiary referral center between 2012 and 2017 were studied retrospectively. The demographic and clinicopathological features of the patients were recorded.
Results: Among all patients with primary and secondary SGTs, the median age was 53 years, 54.6% of the patients were men. Patients with primary tumor constituted 96.8% of all cases. Malignancy rate was 14. Parotid gland was the most common location (90%). Nearly half of all primary tumors were diagnosed as pleomorphic adenoma (n=84, 46.9%). Mucoepidermoid carcinoma was the most common malign neoplasm of the parotid gland. There were only six patients (3.2%) that had secondary SGT.
Conclusion: Pleomorphic adenoma and mucoepidermoid carcinoma were the most common benign and malign pathologies, respectively. The lowest malignancy rate and the highest rate of warthin tumor of the existing literature were the most conspicuous findings of our study. Although the frequency of the secondary SGTs is low, the possibility of metastasis should be considered especially for the patients above 65 years of age.

References

  • Lukšić I, Virag M, Manojlović S, Macan D. Salivary gland tumours: 25 years of experience from a single institution in Croatia. J of Cranio-Maxillofacial Surg. 2012; 40: 75-81.
  • Tumors of the salivary glands. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumors: pathology and genetics of head & neck tumors. IARC Press, Lyon; 2005: 208–28.
  • Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licit ra L. Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 2010; 74: 134-8. (doi: 10.1016/j.critrevonc.2009.10.004)
  • Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. International journal of oral and maxillofacial surgery. 2010; 39: 235-42.
  • Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology. 2012; 114: 230-9.
  • Velázquez CP, Padilla MA, Apo EG, Rivera DQ, Cepeda LA. Tumors of the salivary gland in Mexicans. A retrospective study of 360 cases. Medicina oral, patología oral y cirugía bucal. Ed. inglesa. 2012; 17: 12.
  • Lawal AO, Adisa AO, Kolude B, Adeyemi BF, Olajide MA. A review of 413 salivary gland tumours in the head and neck region. Journal of clinical and experimental dentistry. 2013; 5: 218.
  • Vasconcelos AC, Nör F, Meurer L et al. Clinicopathological analysis of salivary gland tumors over a 15-year period. Brazilian oral research. 2016; 30(1).
  • Kara MI, Göze F, Ezirganli S, Polat S, et al. Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal. 2010; 15: e880-5.
  • Kızıl Y, Aydil U, Ekinci Ö et al. Salivary gland tumors in Turkey: demographic features and histopathological distribution of 510 patients. Indian Journal of Otolaryngology and Head & Neck Sur. 2013; 65: 112-20.
  • Ackerman LV, Del Regato JA: Cancer - diagnosis, treatment and prognosis. St. Louis: C.V. Mosby Co; 1970.
  • Mariano FV, da Silva SD, Chulan TC, de Almeida OP, Kowalski LP. Clinicopathological factors are predictors of distant metastasis from major salivary gland carcinomas. International journal of oral and maxillofacial surgery. 2011; 40: 504-9.
  • Colella G, Biondi P, Itro A, Compilato D, Campisi G. Warthin’s tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue. Minerva Stomatol. 2010; 59: 245-52.
  • Musani MA, Sohail Z, Zafar A, Malik S. Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak. 2008; 18: 274-7.

Türkiye’de tükürük bezi tümörlerinin demografik ve klinikopatolojik özellikleri

Year 2019, Volume: 11 Issue: 4, 450 - 455, 01.12.2019
https://doi.org/10.21601/ortadogutipdergisi.528284

Abstract

Amaç: Tükürük bezi tümörleri (TBT’ler) nadir görülen neoplazmlardır, bu nedenle lokal kayıtlar epidemiyolojik bir bakış açısı elde etmek için değerlidir. Bu çalışma, kliniğimizde opere edilen TBT’lerin demografik ve klinikopatolojik özelliklerini belirlemeyi ve bu bulgular ile Türkiye ve tüm dünyadaki çalışmaları karşılaştırmayı amaçlamıştır.
Gereç ve yöntemler: 2012 ve 2017 yılları arasında bir üçüncü basamak sağlık merkezinin Kulak Burun Boğaz ve Baş Boyun Cerrahisi Kliniği’nde TBT nedeniyle opere edilen 185 hastanın verileri geriye dönük olarak incelendi. Hastaların demografik ve klinikopatolojik özellikleri kaydedildi.
Bulgular: Primer ve sekonder TBT’li tüm hastalar arasında median yaş 53, hastaların %54,6’sı erkekti. Primer tümörlü hastalar tüm vakaların %96,8’ini oluşturmaktaydı. Malignite oranı 14 idi. Parotis bezi en sık lokalizasyondu (%90). Tüm primer tümörlerin yaklaşık yarısına pleomorfik adenom tanısı kondu (n = 84, %46,9). Mukoepidermoid karsinom, parotis bezinin en sık görülen malign neoplazmı idi. Sekonder TBT’si olan sadece altı hasta (%3,2) vardı.
Sonuç: Pleomorfik adenom ve mukopidermoid karsinom sırasıyla en sık görülen benign ve malign patolojilerdir. Literatürdeki en düşük malignite oranı ve en yüksek warthin tümörü oranı çalışmamızın en çarpıcı bulgularıdır. İkincil TBT’lerin sıklığının düşük olmasına rağmen, özellikle 65 yaşın üzerindeki hastalarda metastaz olasılığı düşünülmelidir.

References

  • Lukšić I, Virag M, Manojlović S, Macan D. Salivary gland tumours: 25 years of experience from a single institution in Croatia. J of Cranio-Maxillofacial Surg. 2012; 40: 75-81.
  • Tumors of the salivary glands. In: Barnes L, Eveson JW, Reichart P, Sidransky D (eds) World Health Organization classification of tumors: pathology and genetics of head & neck tumors. IARC Press, Lyon; 2005: 208–28.
  • Guzzo M, Locati LD, Prott FJ, Gatta G, McGurk M, Licit ra L. Major and minor salivary gland tumors. Crit Rev Oncol Hematol. 2010; 74: 134-8. (doi: 10.1016/j.critrevonc.2009.10.004)
  • Tian Z, Li L, Wang L, Hu Y, Li J. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population. International journal of oral and maxillofacial surgery. 2010; 39: 235-42.
  • Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology. 2012; 114: 230-9.
  • Velázquez CP, Padilla MA, Apo EG, Rivera DQ, Cepeda LA. Tumors of the salivary gland in Mexicans. A retrospective study of 360 cases. Medicina oral, patología oral y cirugía bucal. Ed. inglesa. 2012; 17: 12.
  • Lawal AO, Adisa AO, Kolude B, Adeyemi BF, Olajide MA. A review of 413 salivary gland tumours in the head and neck region. Journal of clinical and experimental dentistry. 2013; 5: 218.
  • Vasconcelos AC, Nör F, Meurer L et al. Clinicopathological analysis of salivary gland tumors over a 15-year period. Brazilian oral research. 2016; 30(1).
  • Kara MI, Göze F, Ezirganli S, Polat S, et al. Neoplasms of the salivary glands in a Turkish adult population. Med Oral Patol Oral Cir Bucal. 2010; 15: e880-5.
  • Kızıl Y, Aydil U, Ekinci Ö et al. Salivary gland tumors in Turkey: demographic features and histopathological distribution of 510 patients. Indian Journal of Otolaryngology and Head & Neck Sur. 2013; 65: 112-20.
  • Ackerman LV, Del Regato JA: Cancer - diagnosis, treatment and prognosis. St. Louis: C.V. Mosby Co; 1970.
  • Mariano FV, da Silva SD, Chulan TC, de Almeida OP, Kowalski LP. Clinicopathological factors are predictors of distant metastasis from major salivary gland carcinomas. International journal of oral and maxillofacial surgery. 2011; 40: 504-9.
  • Colella G, Biondi P, Itro A, Compilato D, Campisi G. Warthin’s tumor distribution within the parotid gland. A feasible etiologic source from lymph nodal tissue. Minerva Stomatol. 2010; 59: 245-52.
  • Musani MA, Sohail Z, Zafar A, Malik S. Morphological pattern of parotid gland tumours. J Coll Physicians Surg Pak. 2008; 18: 274-7.
There are 14 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original article
Authors

Ayca Ant 0000-0002-9469-1468

Felat Toprak This is me 0000-0002-5952-7718

Arzubetul Duran This is me 0000-0002-4121-7439

Burcu Vural This is me

Caner Kilic 0000-0003-2879-2524

Tuncay Tunccan This is me 0000-0003-3321-5772

Samet Ozlugedik This is me 0000-0001-7909-9100

Publication Date December 1, 2019
Published in Issue Year 2019 Volume: 11 Issue: 4

Cite

Vancouver Ant A, Toprak F, Duran A, Vural B, Kilic C, Tunccan T, Ozlugedik S. The demographic and clinicopathological features of salivary gland tumors in Turkey. omj. 2019;11(4):450-5.

e-ISSN: 2548-0251

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