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Determination of normal values of thymus tissue using neonatal sonography

Year 2020, Volume: 12 Issue: 1, 29 - 33, 01.03.2020
https://doi.org/10.21601/ortadogutipdergisi.592252

Abstract

Aim: The aim of this study was to determine the normal volumetric values ​​of thymus tissue by sonography in healthy newborns.
Material and Methods: A total of 220 healthy newborns were evaluated by sonography in the first week of life. The shape, size, diameter and thymic index values ​​and variations of both lobes of thymus were evaluated in terms of gestational age, height and weight values ​​and standards were calculated for the reference population.
Results: According to the shape on transverse scans; the thymus was quadrilateral in 136 neonates (61%), round in 34 (15%), bilobate in 28 (13%), and crescent shaped in 22 (10%) in transverse scan. On longitudinal scans, the thymus was triangular in 154 infants (70%), teardrop shaped in 35 (16%), oval in 31 (14%). The range of the thymic transverse diameter along with confidence interval was 1.1–3.9 (mean 2.36±0.63), that of the sagittal area was 1.3–4.93 cm2 (mean 3.01±0.77), that of the thymic index was 3.1–16.9 cm3 (mean 9.12±2.53), that of the AP (Right) was 0.40–2.40 cm (mean 1.37±0.3), that of the AP (left) was 0.30–3.3 cm (mean 1.69±0.48) and that of the AP (mean) was 0.35–2.83 (mean±1.27).
Conclusion: Knowing the reference values ​​in the neonatal period may be meaningful in evaluating the reactive responses of thymus, which is an immunologic organ in this age population.

References

  • Hasselbalch H, Jeppesen DL, Ersbøll AK, Lisse IM, Nielsen MB. Sonographic measurement of thymic size in healthy neonates: Relation to clinical variables. Acta radiol. 1997.
  • Mehta S. Assessment of thymus size in healthy term neonates using sonography-A study from tertiary care hospital of Central India. J Neonatal Perinatal Med. 2015.
  • Varga I, Nescakova E, Toth F, Uhrinova A, Adamkov M. Nutrition and immune system: the size of the thymus as an indicator of the newborn’s nutrition status. Anthropol Anzeiger. 2011.
  • Ekin A, Gezer C, Taner CE, Solmaz U, Gezer NS, Ozeren M. Prognostic value of fetal thy-mus size in intrauterine growth restriction. J Ultrasound Med.
  • Benn CS, Jeppesen DL, Hasselbalch H, Olesen AB, Nielsen J, Björkstén B, et al. Thymus size and head circumference at birth and the development of allergic diseases. Clin Exp Allergy. 2001.
  • Hanquinet S, Rougemont AL, Courvoisier D, Rubbia-Brandt L, McLin V, Tempia M, Anooshiravani M. Acoustic radiation force impulse [ARFI] elas-tography for the noninvasive diagnosis of liver fibrosis in children. Pediatr Radiol [Inter-net]. 2013;43[5]:545–51. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23271404%5Cnhttp://sfx.bibl.ulaval.ca:9003/sfx_local?sid=OVID:medline&id=pmid:23271404&id=doi:10.1007/s00247-012-2595-8&issn=0301-0449&isbn=&volume=43&issue=5&spage=545&pages=545-5
  • Adam EJ, Ignotus PI. Sonography of the thymus in healthy children: Frequency of visualization, size, and appearance. Am J Roentgenol. 1993.
  • Weissmann-Brenner A, Zemet R, Kivilevitch Z, Zalel Y. Sonographic evaluation of the fetal thymus using the thy-box technique between 13 and 16 weeks’ gestation. J Ultrasound Med. 2015.
  • Azad R, Magu S, Gathwala G. Sonographic assessment of the thymus and the measurement of the thymic size in healthy neonates from North India. J Clin Diagnostic Res. 2012.
  • Lemaitre L, Marconi V, Avni F, Remy J. The sonographic evaluation of normal thymus in infants and children. Eur J Radiol. 1987.
  • Tangshewinsirikul C, Panburana P. Sonographic measurement of fetal thymus size in un-complicated singleton pregnancies. J Clin Ultrasound. 2017.
  • Garly ML, Trautner SL, Marx C, Danebod K, Nielsen J, Ravn H, Martins CL, Balé C, Aaby P, Lisse IM. Thymus Size at 6 Months of Age and Subsequent Child Mortality. Journal of Pediatrics. 2008.
  • Re C, Bertucci E, Weissmann-Brenner A, Achiron R, Mazza V, Gindes L. Fetal thymus volume estimation by virtual organ computer-aided analysis in normal pregnancies. J Ultrasound Med. 2015.

Neonatal sonografi ile normal timus dokusu değerlerinin belirlenmesi

Year 2020, Volume: 12 Issue: 1, 29 - 33, 01.03.2020
https://doi.org/10.21601/ortadogutipdergisi.592252

Abstract

Amaç: Bu çalışmanın amacı sağlıklı yenidoğanlarda, timus dokusunun normal volumetrik değerlerini sonografi ile tespit etmektir.
Gereç ve yöntemler: Yaşamın ilk haftasında toplam 220 sağlıklı yenidoğan ultrasonografi ile değerlendirildi. Her iki timus lobunun şekil, boyut, çap ve timik indeks değerleri ve varyasyonları gebelik yaşı, boy ve kilo değerleri açısından değerlendirilmiş ve referans popülasyon için standartlar hesaplanmıştır.
Bulgular: Enine taramalardaki şekle göre; timus 136 yenidoğanda [%61] dörtgen, 34’ünde [%15] yuvarlak, 28’de [%13] bilobat ve çapraz taramada 22’de [%10] hilal şeklindedir. Boyuna taramalarda timüs 154 bebekte [%70] üçgen şeklinde, gözyaşı şeklinde 35 [%16], ovalinde 31 [%14] idi. Timusal transvers çapın güven aralığı ile birlikte aralığı 1,1–3,9 [ortalama 2,36±0,63], sagital bölgeninki 1,3–4,93 cm2 [ortalama 3,01 ± 0,77], timik indeksin 3,1-16,9 cm3 [Ortalama 9,12±2,53], AP’nin [Sağ] 0,40–2,40 cm [ortalama 1,37±0,3], AP’nin [sol] 0,30-2,3 cm [ortalama 1,69±0,48] ve AP’nin [ortalama] ], 0.35-2.83 idi [ortalama±1,27].
Sonuçlar: Yenidoğan döneminde referans değerlerin bilinmesi, bu yaş popülasyonunda immünolojik bir organ olan timusun reaktif tepkilerini değerlendirmede anlamlı olabilir.

References

  • Hasselbalch H, Jeppesen DL, Ersbøll AK, Lisse IM, Nielsen MB. Sonographic measurement of thymic size in healthy neonates: Relation to clinical variables. Acta radiol. 1997.
  • Mehta S. Assessment of thymus size in healthy term neonates using sonography-A study from tertiary care hospital of Central India. J Neonatal Perinatal Med. 2015.
  • Varga I, Nescakova E, Toth F, Uhrinova A, Adamkov M. Nutrition and immune system: the size of the thymus as an indicator of the newborn’s nutrition status. Anthropol Anzeiger. 2011.
  • Ekin A, Gezer C, Taner CE, Solmaz U, Gezer NS, Ozeren M. Prognostic value of fetal thy-mus size in intrauterine growth restriction. J Ultrasound Med.
  • Benn CS, Jeppesen DL, Hasselbalch H, Olesen AB, Nielsen J, Björkstén B, et al. Thymus size and head circumference at birth and the development of allergic diseases. Clin Exp Allergy. 2001.
  • Hanquinet S, Rougemont AL, Courvoisier D, Rubbia-Brandt L, McLin V, Tempia M, Anooshiravani M. Acoustic radiation force impulse [ARFI] elas-tography for the noninvasive diagnosis of liver fibrosis in children. Pediatr Radiol [Inter-net]. 2013;43[5]:545–51. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=medl&AN=23271404%5Cnhttp://sfx.bibl.ulaval.ca:9003/sfx_local?sid=OVID:medline&id=pmid:23271404&id=doi:10.1007/s00247-012-2595-8&issn=0301-0449&isbn=&volume=43&issue=5&spage=545&pages=545-5
  • Adam EJ, Ignotus PI. Sonography of the thymus in healthy children: Frequency of visualization, size, and appearance. Am J Roentgenol. 1993.
  • Weissmann-Brenner A, Zemet R, Kivilevitch Z, Zalel Y. Sonographic evaluation of the fetal thymus using the thy-box technique between 13 and 16 weeks’ gestation. J Ultrasound Med. 2015.
  • Azad R, Magu S, Gathwala G. Sonographic assessment of the thymus and the measurement of the thymic size in healthy neonates from North India. J Clin Diagnostic Res. 2012.
  • Lemaitre L, Marconi V, Avni F, Remy J. The sonographic evaluation of normal thymus in infants and children. Eur J Radiol. 1987.
  • Tangshewinsirikul C, Panburana P. Sonographic measurement of fetal thymus size in un-complicated singleton pregnancies. J Clin Ultrasound. 2017.
  • Garly ML, Trautner SL, Marx C, Danebod K, Nielsen J, Ravn H, Martins CL, Balé C, Aaby P, Lisse IM. Thymus Size at 6 Months of Age and Subsequent Child Mortality. Journal of Pediatrics. 2008.
  • Re C, Bertucci E, Weissmann-Brenner A, Achiron R, Mazza V, Gindes L. Fetal thymus volume estimation by virtual organ computer-aided analysis in normal pregnancies. J Ultrasound Med. 2015.
There are 13 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original article
Authors

Mehmet Burak Ozkan 0000-0003-4672-0671

Sariye Elif Ozyazici Ozkan This is me 0000-0002-3801-522X

Publication Date March 1, 2020
Published in Issue Year 2020 Volume: 12 Issue: 1

Cite

Vancouver Ozkan MB, Ozyazici Ozkan SE. Determination of normal values of thymus tissue using neonatal sonography. otd. 2020;12(1):29-33.

e-ISSN: 2548-0251

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