New predictive parameters of PFAPA syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Year 2020, Volume: 12 Issue: 1, 69 - 72, 01.03.2020

Serkan Kayabaşı Fatih Gül

https://doi.org/10.21601/ortadogutipdergisi.633701

Abstract

ERRATUM NOTICE: Some errors in the article entitled “New predictive parameters of Pfapa syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio” which was previously published in Vol. 11 No. 3 pp. 231-244 with DOI “10.21601/ortadogutipdergisi.456084” at https://dergipark.org.tr/tr/pub/ortadogutipdergisi/issue/46899/456084 was recognized by the authors. This article is the corrected version of the original article.

Objective: In this study, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), which are new markers of inflammation, were compared between patients diagnosed with PFAPA syndrome and healthy individuals.
Material and Method: Thirty patients (Pf group) (16 males, 14 females; mean age 3.33; range 1-21 years) diagnosed with PFAPA syndrome and 30 healthy individuals (15 males, 15 females; mean age 4.01 years; range 1-23 years) (control group) were included in the study. Hematologic parameters of both groups were compared statistically. Neutrophil, lymphocyte, platelet values and NLR and TLO ratios were used for comparison.
Results: When neutrophil, lymphocyte and platelet values were compared, no difference was observed between Pf and control groups (p> 0.05). When the NLR ratios were compared, a statistically significant increase was detected in the Pf group (p = 0.012). When the PLR ratios were compared, no statistical difference was observed (p = 0.117).
Conclusion: PFAPA syndrome is usually diagnosed clinically. However, in diagnosis of difficult clinical cases, the rate of NLR may be helpful as a laboratory finding.

Keywords

PFAPA syndrome, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio

PFAPA sendromunda yeni öngörücü parametreler: nötrofil-lenfosit oranı ve trombosit-lenfosit oranı

Abstract

DÜZELTME YAZISI: Dergimizin 11. Cilt 3. Sayı 231-234 sayfaları arası, “10.21601/ortadogutipdergisi.456084” DOI numarası
ile, https://dergipark.org.tr/tr/pub/ortadogutipdergisi/issue/46899/456084 internet adresinde yayımlanan “Pfapa sendromunda yeni öngörücü parametreler: nötrofil lenfosit oranı ve trombosit lenfosit oranı” isimli makalede bulunan bazı hatalar, yazarlar tarafından fark edilmiştir. Bu makale, orijinal makalede yer alan hataların giderilmesi amacı ile hazırlanmış düzeltilmiş versiyondur.

Amaç: Bu çalışmada PFAPA sendromu tanısı konulan hastalar ile sağlıklı bireyler yeni inflamasyon belirteçlerinden olan nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranı (TLO) bakımından karşılaştırıldı.
Gereç ve Yöntem: Çalışmaya PFAPA sendromu tanısı konulmuş 30 hasta (Pf grubu) (16 erkek, 14 kadın; ort. yaş 3,33; dağılım 1-21 yıl) ile 30 sağlıklı birey (15 erkek, 15 kadın; ort. yaş 4,01 yıl; dağılım 1-23 yıl) (kontrol grubu) dahil edildi. Her iki grubun hematolojik parametreleri istatiksel olarak karşılaştırıldı. Nötrofil, lenfosit, trombosit değerleri ile NLO ve TLO oranları kullanıldı.
Bulgular: Nötrofil, lenfosit ve trombosit değerleri karşılaştırıldığında Pf ve kontrol grubu arasında bir fark gözlenmedi (p>0.05). NLO oranları karşılaştırıldığında Pf grubunda (p=0,012) istatiksel olarak anlamlı yükseklik saptandı. TLO oranları karşılaştırıldığında ise istatiksel fark gözlenmedi (p=0,117).
Sonuç: PFAPA sendromu tanısı genellikle klinik olarak konulmaktadır. Ancak tanısı zor konan vakalarda NLO oranı bir laboratuvar bulgusu olarak yardımcı olabilir.

Keywords

PFAPA sendromu, nötrofil-lenfosit oranı, trombosit-lenfosit oranı

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