New predictive parameters of PFAPA syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio

Year 2020, Volume: 12 Issue: 1, 69 - 72, 01.03.2020

Serkan Kayabaşı , Fatih Gül

https://doi.org/10.21601/ortadogutipdergisi.633701

Abstract

ERRATUM NOTICE: Some errors in the article entitled “New predictive parameters of Pfapa syndrome: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio” which was previously published in Vol. 11 No. 3 pp. 231-244 with DOI “10.21601/ortadogutipdergisi.456084” at https://dergipark.org.tr/tr/pub/ortadogutipdergisi/issue/46899/456084 was recognized by the authors. This article is the corrected version of the original article.

Objective: In this study, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), which are new markers of inflammation, were compared between patients diagnosed with PFAPA syndrome and healthy individuals.
Material and Method: Thirty patients (Pf group) (16 males, 14 females; mean age 3.33; range 1-21 years) diagnosed with PFAPA syndrome and 30 healthy individuals (15 males, 15 females; mean age 4.01 years; range 1-23 years) (control group) were included in the study. Hematologic parameters of both groups were compared statistically. Neutrophil, lymphocyte, platelet values and NLR and TLO ratios were used for comparison.
Results: When neutrophil, lymphocyte and platelet values were compared, no difference was observed between Pf and control groups (p> 0.05). When the NLR ratios were compared, a statistically significant increase was detected in the Pf group (p = 0.012). When the PLR ratios were compared, no statistical difference was observed (p = 0.117).
Conclusion: PFAPA syndrome is usually diagnosed clinically. However, in diagnosis of difficult clinical cases, the rate of NLR may be helpful as a laboratory finding.

Keywords

PFAPA syndrome, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio

PFAPA sendromunda yeni öngörücü parametreler: nötrofil-lenfosit oranı ve trombosit-lenfosit oranı

Abstract

DÜZELTME YAZISI: Dergimizin 11. Cilt 3. Sayı 231-234 sayfaları arası, “10.21601/ortadogutipdergisi.456084” DOI numarası
ile, https://dergipark.org.tr/tr/pub/ortadogutipdergisi/issue/46899/456084 internet adresinde yayımlanan “Pfapa sendromunda yeni öngörücü parametreler: nötrofil lenfosit oranı ve trombosit lenfosit oranı” isimli makalede bulunan bazı hatalar, yazarlar tarafından fark edilmiştir. Bu makale, orijinal makalede yer alan hataların giderilmesi amacı ile hazırlanmış düzeltilmiş versiyondur.

Amaç: Bu çalışmada PFAPA sendromu tanısı konulan hastalar ile sağlıklı bireyler yeni inflamasyon belirteçlerinden olan nötrofil-lenfosit oranı (NLO) ve trombosit-lenfosit oranı (TLO) bakımından karşılaştırıldı.
Gereç ve Yöntem: Çalışmaya PFAPA sendromu tanısı konulmuş 30 hasta (Pf grubu) (16 erkek, 14 kadın; ort. yaş 3,33; dağılım 1-21 yıl) ile 30 sağlıklı birey (15 erkek, 15 kadın; ort. yaş 4,01 yıl; dağılım 1-23 yıl) (kontrol grubu) dahil edildi. Her iki grubun hematolojik parametreleri istatiksel olarak karşılaştırıldı. Nötrofil, lenfosit, trombosit değerleri ile NLO ve TLO oranları kullanıldı.
Bulgular: Nötrofil, lenfosit ve trombosit değerleri karşılaştırıldığında Pf ve kontrol grubu arasında bir fark gözlenmedi (p>0.05). NLO oranları karşılaştırıldığında Pf grubunda (p=0,012) istatiksel olarak anlamlı yükseklik saptandı. TLO oranları karşılaştırıldığında ise istatiksel fark gözlenmedi (p=0,117).
Sonuç: PFAPA sendromu tanısı genellikle klinik olarak konulmaktadır. Ancak tanısı zor konan vakalarda NLO oranı bir laboratuvar bulgusu olarak yardımcı olabilir.

Keywords

PFAPA sendromu, nötrofil-lenfosit oranı, trombosit-lenfosit oranı

References

• Caorsi R, Pelagatti MA, Federici S, Finetti M, Martini A, Gattorno M. Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome. Curr Opin Rheumatol. 2010;22:579–84.
• Padeh S, Stoffman N, Berkun Y. Periodic fever accompanied by aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA syndrome) in adults. Isr Med Assoc J. 2008;10:358-60.
• Thomas KT, Feder HM, Lawton AR, Edwards KM. Periodic fever syndrome in chıldren. J Pediatr 1999;135:15-21.
• Cantarini L, Vitale A, Bartolomei B, Galeazzi M, Rigante D. Diagnosis of PFAPA syndrome applied to a cohort of 17 adults with unexplained recurrent fevers. Clin Exp Rheumatol. 2012;30:269–71.
• Wang D, Yang JX, Cao DY, Wan XR, Feng FZ, Huang HF, ve ark. Preoperative neutrophil-lymphocyte and platelet-lymphocyte ratios as independent predictors of cervical stromal involvement in surgically treated endometrioid adenocarcinoma. Onco Targets Ther 2013;6:211-6.
• Bhat T, Teli S, Rijal J, Bhat H, Raza M, Khoueiry G, ve ark. Neutrophil to lymphocyte ratio and cardiovascular diseases: a review. Expert Rev Cardiovasc Ther 2013;11:559.
• Ulu S, Ulu MS, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-lymphocyte ratio as a new, quick, and reliable indicator for predicting diagnosis and prognosis of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2013;34:1400-4.
• Bucak A, Ulu S, Oruc S, Yucedag F, Tekin MS, Karakaya F, ve ark. Neutrophil-to-lymphocyte ratio as a novel potential marker for predicting prognosis of Bell palsy. Laryngoscope 2014;124:1678-81.
• Rudiger A, Burckhardt OA, Harpes P. The relative lymphocyte count on hospital admission is a risk factor for long-term mortality in patients with acute heart failure. Am J Emerg Med 2006;24:451–4.
• Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of allcause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis 2012;34:326-34.
• Atan D, Özcan KM, Köseoğlu S, İkincioğulları A, Çetin MA, Ensari S, Dere H. New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Kulak Burun Bogaz Ihtis Derg 2015;25:97-101.
• Turkmen K. Platelet-to-Lymphocyte Ratio: One of the novel and valuable platelet indices in hemodialysis patients. Hemodial Int 2013;17:670.