Pterjium cerrahisi sonrası otolog serum ve dekspantenol jellerin subjektif semptomlarının karşılaştırılması

Year 2020, Volume: 12 Issue: 2, 170 - 174, 01.06.2020

Ugur Gürlevik Mehmet Çıtırık Erdoğan Yaşar Sevilay Karahan

https://doi.org/10.21601/ortadogutipdergisi.680702

Abstract

Amaç: Bu çalışmanın amacı, pterjiyum cerrahisi sonrası otolog serum ve dekspantenol jelin subjektif semptomlar üzerindeki etkisini araştırmaktır.
Metod: Haziran 2017 ve Aralık 2017 tarihleri arasında aynı cerrah tarafından yapılan pterjiyum cerrahisi uygulanan hastaların değerlendirilmesi yapıldı. Hastalar 2 gruba ayrıldı. Grup 1’de (n: 18) ameliyat sonrası otolog serum kullananlar ve grup 2’de (n: 12) %5 dekspantenol jel kullanılar vardı. Her iki grupta da postoperatif ağrı, batma, tahriş, kızarıklık ve greft ödemi yönünden değerlendirme yapıldı.
Bulgular: Gruplar arasında 1., 3. ve 7. günlerde ağrı, batma ve tahriş açısından istatistiksel olarak anlamlı fark yoktu. Dekspantenol kullanan grupta 3 ve 7. günlerde 1. güne göre bu şikayetlerde istatistiksel olarak anlamlı bir azalma gözlendi. Gruplar arasında kızarıklık ve greft ödemi açısından 1., 3. ve 7. günlerde istatistiksel olarak anlamlı fark yoktu. Her iki grupta da, bu bulgularda 3. ve 7. günlerde 1. güne göre istatistiksel olarak anlamlı bir artış tespit edildi.
Sonuç: Pterjiyum cerrahisi sonrası birçok ajan hasta konforunu arttırmaktadır. Otolog serum en güvenilir ve en çok araştırılan ajandır. %5 Dexpanthenol jel, hastanın konforu ve yara iyileşmesi açısından ön segment cerrahisine alternatif olabilir.

Keywords

dexpanthenol, pterygium, otolog serum, sözel ağrı ölçeği

Comparison of subjective symptoms of autologous serum and dexpanthenol gels after pterygium surgery

Abstract

Purpose: The aim of this study was to investigate the effect of autologous serum and dexpanthenol gel on subjective symptoms after pterygium surgery.
Methods: An evaluation was made of patients who underwent the same technique of pterygium surgery between June 2017 and December 2017. Patients were divided into 2 groups with autologous serum used postoperatively in Group 1 (n: 18) and 5% dexpanthenol gel in Group 2 (n: 12). Evaluation was made of both groups in respect of postoperative pain, stinging, irritation, redness and graft edema.
Results: There was no statistically significant difference between the groups in respect of pain, stinging and watering on the 1st, 3rd and 7th days. A statistically significant decrease in these complaints was observed on days 3 and 7 in the group using dexpanthenol. There was no statistically significant difference between the groups on days 1, 3 and 7in respect of redness and graft edema. In both groups, a statistically significant increase was determined in these findings on days 3 and 7.
Conclusion: After pterygium surgery, many agents increase the comfort of patients. Autologous serum is the most reliable and most investigated agent. Dexpanthenolmay be an alternative to anterior segment surgery in respect of patient comfort and wound healing.

Keywords

dexpanthenol, pterygium, autologous serum, verbal pain scale

References

• Karukonda SR, Thompson HW, Beuerman RW, Lam DS, Wilson R, Chew SJ, Steinemann TL. Cell cycle kinetics in pterygium at three latitudes. Br J Ophthalmol. 1995; 79: 313-7.
• Mackenzie FD, Hirst LW, Battistuta D, Green A. Risk analysis in the development of pterygia. Ophthalmol. 1992; 99: 1056-61.
• Buratto L, Phillips RL, Carito G. Part A. Chapter 9. Symptoms. In: Buratto L, Phillips RL, Carito G, eds. Pterygium Surgery. Thorofare, NJ: SLACK Inc., 2000: 5-6.
• Sanchez-Avila RM, Merayo-Lloves J, Riestra AC, Berisa S, Lisa C, Sánchez JA, Muruzabal F, et al. Plasma rich in growth factors membrane as coadjuvant treatment in the surgery of ocular surface disorders. Medicine (Baltimore). 2018; 97: e0242.
• Egger SF, Huber-Spitzy V, Alzner E, Scholda C, Vecsei VP. Corneal wound healing after superficial foreign body injury: vitamin A and dexpanthenol versus calf blood extract. Ophthalmologica 1999; 213: 246-9.
• Scardovi C, De Felice GP, Gazzaniga A. epidermal growth factor in the topical treatment of traumatic corneal ulcers. Ophthalmologica. 1993; 206: 119-24.
• Fox RI, Chan R, Michelson JB, Belmont JB, Michelson PE. Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum. 1984; 27: 459-61.
• Kaya FS, Akova Y. The Effect of Autologous Serum Eye Drop Application on Epithelization in the Treatment of Various Ocular Surface Disorders and its Safety. Turk J Ophthalmol 2012; 42: 336-41.
• Pastor JC, CalongeM. Epidermal growth factor and corneal wound healing: a multicenter study. Cornea. 1992; 11: 311-4.
• Fredj-Reygrobellet D, Plouet J, Delayre T, Baudouin C, Bourret F, Lapalus P. Effects of aFGF and bFGF on wound healing in rabbit corneas. Curr Eye Res. 1987; 6: 1205-9.
• Hanck AB, Goffin H. Dexpanthenol (Ro 01-4709) in the treatment of constipation. Acta Vitaminol Enzymol. 1982; 4: 87-97.
• Christ T. Treatment of corneal erosion with a new ophthalmic gel containing panthenol. Spektrum der Augenheilkunde 1994; 8: 224-6.
• Raczyńska K, Iwaszkiewicz-Bilikiewicz B, Stozkowska W, Sadlak-Nowicka J. Clinical evaluation of provitamin B5 drops and gel for postoperative treatmentof corneal and conjuctival injuries. Klin Oczna. 2003; 105: 175-8.
• Baumeister M, Bühren J, Ohrloff C, Kohnen T. Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. Ophthalmologica. 2009; 223: 414-8.