Investigation of Adsorption of the Cardiotonic Drug Milrinone Onto Montmorillonite: An FTIR and Raman Spectroscopic Study

Year 2024, Volume: 2 Issue: 1, 37 - 40, 11.06.2024

Sevim Akyüz

https://doi.org/10.26650/PAR.2024.00005

Abstract

Milrinone is a cardiotonic drug that is used for the treatment of congestive heart failure. Clay minerals are widely used materials as a low-cost nanocarriers in designing drug delivery systems. Drug-clay interaction is important since it affects drug action. Montmorillonite, a clay mineral with high adsorption and swelling properties, is useful as a low-cost nanocarrier in deisgning drug delivery systems. The adsorption of a molecule on a clay surface, or formation of intercalates, gives rise to changes in the vibrational wavenumbers of the adsorbed molecule. In this study, interaction between the adsorbed milrinone molecules and montmorillonite was investigated by FT-IR and Raman spectrometry. The X-ray diffraction patterns of montmorillonite before and after treatment with milrinone showed a significant change in the d(001) reflectance of clay. This reflection peak shifted to a lower angle due to the adsorption of milrinone onto the clay. The result indicated the intercalation of the milrinone molecules by increasing the interlayer spacing of the clay. Vibrational spectroscopic results indicated that intercalated milrinone interacted with clay by direct or indirect coordination (through water molecules) to exchangeable cations or the Lewis acidic centers.

Keywords

Clays, Milrinone, Montmorillonite, FTIR, Raman

References

• Aguzzi C., Cerezo P., Viseras C., Caramella C., 2007, Applied Clay Science, 36, 22 google scholar
• Akalin E., Yilmaz A., Akyuz S., 2005, Journal of Molecular Structure, 244, 881 google scholar
• Akalin E., Akyuz S., Akyuz T., 2007, Journal of Molecular Structure, 834, 477 google scholar
• Akyuz S., Akyuz T., 2008, Vibrational Spectroscopy, 48, 229 google scholar
• Akyuz S., Akyuz T, 2010, Vibrational Spectroscopy, 53, 136 google scholar
• Borrego-Sânchez A., Carazo E., Aguzzi C., Viserasa C., Saiıız-Dıaz google scholar
• C. I., 2018, Applied Clay Science, 160, 173 google scholar
• Destexhe A., Smets J., Adamowicz L., Maes G., 1994, Journal of Physical Chemistry, 98, 1506 google scholar
• Dines T. J., MacGregor L. D., Rochester C. H., 2003, Spectrochimica Acta A, 59, 3205 google scholar
• Esme A., 2017, Indian Journal of Pure & Applied Physics, 55, 478 google scholar
• Katti K., Katti D., 2006, Langmuir, 22, 532 google scholar
• Massaro M., Colletti C. G., Lazzara G., Riela S., 2018, Journal of Functional Biomaterials, 9, 58 google scholar
• Rocha M. C., Galdino T., Trigueiro P., Honorio L.M.C. et al., 2022, Pharmaceutics, 14, 796 google scholar
• Schulze D. G., 2005, Clay Minerals (Ed: Hillel, D.) in Encyclopedia of Soils in the Environment, Elsevier, 246 google scholar
• Shipley J. B., Tolman D., Hastillo A., Hess M. L., 1996, The American Journal of the Medical Sciences, 311, 286 google scholar
• Theng B. K. G., 1974, The Chemistry of Clay Organic Reactions, Hilger, London, 1974 google scholar
• Young R. A., Ward A., 1988, Drugs, 36, 158 google scholar