Polikistik over sendrom tanılı hastalarda Adropin ve Lipokalin düzeylerinin incelenmesi

Year 2022, , 141 - 147, 01.01.2022

Soner Gök , İ.veysel Fenkci , Erkan Alataş , Babür Kaleli , Yaşar Enli

https://doi.org/10.31362/patd.1005190

Abstract

Amaç: Polikistik Over Sendromu (PKOS) metabolik bozukluklarla ilişkilidir. Bunlar özellikle endotel disfonksiyonu, insülin direnci, sistemik inflamasyon ve dislipidemi olarak belirtilmiştir. PKOS’lu hastalarda glikoz homeostazı ve hepatik steatozu olumlu bir biçimde etkileyen peptit yapılı bir salgı ‘adropin’ olarak adlandırılır. Lipokalin-2 apoptoziste aracı rolü üstlenmekte ve IL-3, obezite, insülin direnci tarafından uyarılmaktadır. Bu araştırmada PKOS’lu hastalarda adropin ve lipokalin-2 seviyeleri araştırılmıştır.
Gereç ve yöntem: Bu gözlemsel ve kesitsel çalışmada hastalar 18-38 yaş aralığında PKOS tanısı almış (n=37) ve sağlıklı kadın kontrol grubu (n=34) olarak sınıflandırıldı. Her iki grupta demografik veriler, metabolik ve hormonal değerler, antropometrik ölçümler, serum Lipokalin-2 ve Adropin seviyeleri ölçüldü.
Bulgular: Araştırmada PKOS’lu hasta grubunda Lipokalin-2 ve Adropin düzeylerindeki düşüşün anlamlı olduğu bulunmuştur. Kontrol grubunda LDL-C kolesterol, Total kolesterol, Total testosteron, LH, FAI, Trigliserit ve LH/FSH değerleri ve hirsutizm skoru PKOS grubuna göre daha düşük seviyelerde saptanmıştır.
Sonuç: Adropinin PKOS’ta insülinden bağımsız olarak farklılaşması PKOS’lu hastalarda insülin direnci tespiti ve gelişimi ortaya konulmadan adropin düzeylerindeki anlamlı azalma sonucu ortaya konulmaktadır. Çalışma insülin direncinin patolojik seviyelere gelmeden adropin düzeyinin anlamlı olarak azaldığını ve bu durumun popülasyonun genç olması ile ilişkili olduğunu göstermektedir. PKOS’da apoptozise ikincil insülin reseptör fonksiyon bozukluğunun Lipokalin-2 seviyeleri ile ilişkili olmadığı ve bunun nedeninin PKOS’lu hastalarda Lipokalin-2 seviyelerinin düşük olmasından kaynaklandığı vurgulanmaktadır. 

Keywords

Adropin, lipokalin, insulin, polikistik over sendromu

Supporting Institution

Pamukkale Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi

Project Number

1904

The evaluation of serum Adropin and Lipocalin levels in women with polycystic ovary syndrome

Abstract

Purpose: Polycystic Ovary Syndrome (PCOS) is related to metabolic diseases such as endothelial dysfunction, systemic inflammation, insülin resistance and dyslipidemia. Adropin is a peptide secretion that positively affects glucose homeostasis and hepatic steatosis in patients with PCOS. Lipocalin-2 mediates obesity, insulin resistance, and apoptosis induced by IL-3. The levels of adropin and lipocalin-2 in PCOS patients were studied in this study.
Materials and methods: Women with PCOS (n=37) and healthy controls (n=34) were assessed in this observational and cross-sectional study. Anthropometric measurements, demographic data, metabolic and hormonal profiles, Adropin and Lipocalin-2 levels were measured in both groups.
Results: In the study it was determined that PCOS group Adropin and Lipocalin-2 levels were significantly reduced. LDL-C cholesterol, Total cholesterol, Total testosterone, LH, FAI, Triglyceride and LH/FSH values and hirsutism score considerably lower in the control group than the PCOS group.
Conclusion: The fact that adropin levels were reduced significantly in PCOS patients who had not yet acquired insulin resistance or who could not be detected using existing methods suggests that adropin changes in PCOS are independent of insulin. The study shows that the level of adropin decreases significantly before insulin resistance reaches pathological levels, which is associated with the young population. Low Lipocalin-2 levels in patients with PCOS suggest that this cannot be blamed for insulin receptor dysfunction secondary to apoptosis in PCOS.

Keywords

Adropin, lipocalin, insulin, polycystic ovary syndrome

Project Number

1904

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