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Koronavirüs 19 hastalığı ve kuru göz

Year 2022, , 355 - 360, 01.04.2022
https://doi.org/10.31362/patd.1064600

Abstract

Amaç: Koronavirüs 19 (COVID-19) geçiren hastalarda kuru göz varlığının araştırılması.
Gereç ve yöntem: Çalışma prospektif olarak planlandı. Süleyman Demirel Üniversitesi Tıp Fakültesi hastanesine rutin göz muayenesi için başvuran ve son 6 ay içerisinde COVID-19 geçirmiş 27 hastanın 54 gözü ile yaş ve cinsiyet bakımından uyumlu 30 sağlıklı bireyin 60 gözü çalışmaya dâhil edildi. Tüm olgulara gözyaşı kırılma zamanı (BUT) ve Schirmer 1 (anestezisiz) testi uyguladı.
Bulgular: Ortalama yaş hasta grubunda 30,1±7,7, kontrol grubunda 29,6±6,2 idi. COVID-19 geçirilmesi
üzerinden geçen zaman ortalama 11,6±7,2 hafta (min 2-maks 24) idi. BUT değeri hasta grubunda ortalama
11,46±3,96, kontrol grubunda ise 11,70±3,52 saniye idi ve iki grup arasında istatistiksel olarak anlamlı fark yoktu (p>0,05). Schirmer testi hasta grubunda ortalama 18,75±7,82, kontrol grubunda ise 17,31±6,23 mm idi ve iki grup arasında istatistiksel olarak anlamlı fark yoktu (p>0,05). Covid grubunda rastlanan oküler bulgular gözde sulanma ve kızarıklık (%11) ve peribulber ağrı (%7) idi.
Sonuç: COVID-19 geçirmiş bireylerin gözyaşı testlerinin normal bireylerden farklı olmadığı görüldü. COVID-
19’un kuru göze neden olmadığı sonucuna varıldı.

References

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  • 2. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
  • 3. WHO Coronavirus disease (COVID-19) Weekly Epidemiological Update and Weekly Operational Update, October 2021. Available at: https://www.worldometers.info/coronavirus/coronavirus-cases/. Accessed October 11, 2021
  • 4. Willcox MD, Walsh K, Nichols JJ, Morgan PB, Jones LW. The ocular surface, coronaviruses and COVID-19. Clin Exp Optom 2020;103:418-424. https://doi.org/10.1111/cxo.13088
  • 5. Wu P, Duan F, Luo C, et al. Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol 2020;138:575-578. https://doi.org/10.1001/jamaophthalmol.2020.1291
  • 6. Seah I, Agrawal R. Can the coronavirus disease 2019 (COVID-19) affect the eyes? A review of coronaviruses and ocular ımplications in humans and animals. Ocul Immunol Inflamm 2020;28:391-395. https://doi.org/10.1080/09273948.2020.1738501
  • 7. Ho D, Low R, Tong L, Gupta V, Veeraraghavan A, Agrawal R. COVID-19 and the ocular surface: a review of transmission and manifestations. Ocul Immunol Inflamm 2020;28:726-734. https://doi.org/10.1080/09273948.2020.1772313
  • 8. Chen L, Deng C, Chen X, et al. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmol 2020;98:951-959. https://doi.org/10.1111/aos.14472
  • 9. Wei H, Yin H, Huang M, Guo Z. The 2019 novel cornoavirus pneumonia with onset of oculomotor nerve palsy: a case study. J Neurol 2020;267:1550-1553. https://doi.org/10.1007/s00415-020-09773-9
  • 10. Belghmaidi S, Nassih H, Boutgayout S, et al. Third cranial nerve palsy presenting with unilateral diplopia and strabismus in a 24-year-old woman with COVID-19. Am J Case Rep 2020;21:e925897. https://doi.org/10.12659/AJCR.925897
  • 11. Dumitrascu OM, Volod O, Bose S, Wang Y, Biousse V, Lyden PD. Acute ophthalmic artery occlusion in a COVID-19 patient on apixaban. J Stroke Cerebrovasc Dis 2020;29:104982. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104982
  • 12. Walinjkar JA, Makhija SC, Sharma HR, Morekar SR, Natarajan S. Central retinal vein occlusion with COVID-19 infection as the presumptive etiology. Indian J Ophthalmol 2020;68:2572-2574. https://doi.org/10.4103/ijo.IJO_2575_20
  • 13. Montesel A, Bucolo C, Mouvet V, Moret E, Eandi CM. Case report: central retinal artery occlusion in a COVID-19 patient. Front Pharmacol 2020;11:588384. https://doi.org/10.3389/fphar.2020.588384
  • 14. Ucar F, Cetinkaya S. Central retinal artery occlusion in a patient who contracted COVID-19 and review of similar cases. BMJ Case Rep 2021;14:e244181. https://doi.org/10.1136/bcr-2021-244181
  • 15. Bapaye MM, Nair AG, Bapaye CM, Bapaye MM, Shukla JJ. Simultaneous bilateral central retinal artery occlusion following COVID-19 infection. Ocul Immunol Inflamm 2021;29:671-674. https://doi.org/10.1080/09273948.2021.1891262
  • 16. Been Sayeed SKJ, Chandra Das S, Mahmud R, Moniruzzaman M, Rahman MM. Acute ıschemic stroke with central retinal artery occlusion as a rare presentation of COVID-19 disease. Been Sayeed SKJ, Chandra Das S, Mahmud R, Moniruzzaman M, Rahman MM. Cureus 2021;13:e17469. https://doi.org/10.7759/cureus.17469
  • 17. Oronsky B, Larson C, Hammond TC, et al. A review of Persistent Post-COVID Syndrome (PPCS). Clin Rev Allergy Immunol 2021:1-9. https://doi.org/10.1007/s12016-021-08848-3
  • 18. Chippa V, Aleem A, Anjum F. Post acute coronavirus (COVID-19) syndrome. 2021 Oct 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. PMID: 34033370
  • 19. Wolffsohn JS, Arita R, Chalmers R, et al. TFOS DEWS II diagnostic methodology report. Ocul Surf 2017;15:539-574. https://doi.org/10.1016/j.jtos.2017.05.001
  • 20. Wang MTM, Muntz A, Lim J, et al. Ageing and the natural history of dry eye disease: a prospective registry-based cross-sectional study. Ocul Surf 2020;18:736-741. https://doi.org/10.1016/j.jtos.2020.07.003
  • 21. Zhou Y, Zeng Y, Tong Y, Chen C. Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva. MedRxiv 2020. https://doi.org/10.1101/2020.02.11.20021956
  • 22. Chen L, Liu M, Zhang Z, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020;bjophthalmol-2020-316304. doi:10.1136/bjophthalmol-2020-316304
  • 23. Lin L, Li TS. [Interpretation of "Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 5)"]. Zhonghua Yi Xue Za Zhi 2020;100:e001. https://doi.org/10.3760/cma.j.issn.0376-2491.2020.0001
  • 24. Deng W, Bao L, Gao H, et al. Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques. Nat Commun 2020;11:4400. https://doi.org/10.1038/s41467-020-18149-6
  • 25. Bertoli F, Veritti D, Danese C, et al. Ocular findings in COVID-19 patients: a review of direct manifestations and indirect effects on the eye.J Ophthalmol 2020;2020:4827304. https://doi.org/10.1155/2020/4827304
  • 26. Dobesh PP, Trujillo TC. Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID-19.Pharmacotherapy. 2020 Nov;40(11):1130-1151. doi: 10.1002/phar.2465. Review.
  • 27. Nannoni S, de Groot R, Bell S, Markus HS. Stroke in COVID-19: A systematic review and meta-analysis.Int J Stroke. 2021 Feb;16(2):137-149. doi: 10.1177/1747493020972922.
  • 28. Foster KJ, Jauregui E, Tajudeen B, Bishehsari F, Mahdavinia M. Smell loss is a prognostic factor for lower severity of coronavirus disease 2019. Ann Allergy Asthma Immunol 2020;125:481-483. https://doi.org/10.1016/j.anai.2020.07.023
  • 29. Talavera B, García Azorín D, Martínez Pías E, et al. Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci 2020;419:117163. https://doi.org/10.1016/j.jns.2020.117163
  • 30. Renaud M, Thibault C, Le Normand F, et al. Clinical outcomes for patients with anosmia 1 year after COVID-19 diagnosis. JAMA Netw Open 2021;4:e2115352. https://doi.org/10.1001/jamanetworkopen.2021.15352

COVID-19 and dry eye

Year 2022, , 355 - 360, 01.04.2022
https://doi.org/10.31362/patd.1064600

Abstract

Purpose: To evaluate the dry eye in patients with Corona virus 19 disease (COVID-19).
Materials and methods: In this prospective study 54 eyes of 27 patients who had COVID-19 within last 6
months and 60 eyes of 30 age and sex matched healthy controls were included. After the eye examination the tear film break-up time (BUT) and Schirmer 1 test (without anesthesia) was performed in all subjects.
Results: The mean age was 30.1±7.7 in study group and 29.6±6.2 in controls. The mean time after recovery
of COVID-19 was 11,6±7,2 weeks (min 2-max 24). The mean BUT value was 11.46±3.96 seconds in the study
grup and 11.70±3.52 seconds in controls and the difference between two groups was not statically significant (p>0.05). The mean Schirmer 1 test value was 18.75±7.82 mm in the study group and 17.31±6.23 mm in controls and the difference between two groups was not statically significant (p>0.05). There was no ocular findings other than epiphora and hyperaemia (11%) and periocular pain (7%) in COVID-19 group.
Conclusions: There was no difference in dry eye tests between COVID-19 patients and healthy subjects.
COVID-19 may not cause dry eye in patients.

References

  • 1. Cascella M, Rajnik M, Aleem A, Dulebohn SC, Di Napoli R. Features, evaluation, and treatment of coronavirus (COVID-19). 2021 Sep 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–.PMID: 32150360
  • 2. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395:497-506. https://doi.org/10.1016/S0140-6736(20)30183-5
  • 3. WHO Coronavirus disease (COVID-19) Weekly Epidemiological Update and Weekly Operational Update, October 2021. Available at: https://www.worldometers.info/coronavirus/coronavirus-cases/. Accessed October 11, 2021
  • 4. Willcox MD, Walsh K, Nichols JJ, Morgan PB, Jones LW. The ocular surface, coronaviruses and COVID-19. Clin Exp Optom 2020;103:418-424. https://doi.org/10.1111/cxo.13088
  • 5. Wu P, Duan F, Luo C, et al. Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei Province, China. JAMA Ophthalmol 2020;138:575-578. https://doi.org/10.1001/jamaophthalmol.2020.1291
  • 6. Seah I, Agrawal R. Can the coronavirus disease 2019 (COVID-19) affect the eyes? A review of coronaviruses and ocular ımplications in humans and animals. Ocul Immunol Inflamm 2020;28:391-395. https://doi.org/10.1080/09273948.2020.1738501
  • 7. Ho D, Low R, Tong L, Gupta V, Veeraraghavan A, Agrawal R. COVID-19 and the ocular surface: a review of transmission and manifestations. Ocul Immunol Inflamm 2020;28:726-734. https://doi.org/10.1080/09273948.2020.1772313
  • 8. Chen L, Deng C, Chen X, et al. Ocular manifestations and clinical characteristics of 535 cases of COVID-19 in Wuhan, China: a cross-sectional study. Acta Ophthalmol 2020;98:951-959. https://doi.org/10.1111/aos.14472
  • 9. Wei H, Yin H, Huang M, Guo Z. The 2019 novel cornoavirus pneumonia with onset of oculomotor nerve palsy: a case study. J Neurol 2020;267:1550-1553. https://doi.org/10.1007/s00415-020-09773-9
  • 10. Belghmaidi S, Nassih H, Boutgayout S, et al. Third cranial nerve palsy presenting with unilateral diplopia and strabismus in a 24-year-old woman with COVID-19. Am J Case Rep 2020;21:e925897. https://doi.org/10.12659/AJCR.925897
  • 11. Dumitrascu OM, Volod O, Bose S, Wang Y, Biousse V, Lyden PD. Acute ophthalmic artery occlusion in a COVID-19 patient on apixaban. J Stroke Cerebrovasc Dis 2020;29:104982. https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104982
  • 12. Walinjkar JA, Makhija SC, Sharma HR, Morekar SR, Natarajan S. Central retinal vein occlusion with COVID-19 infection as the presumptive etiology. Indian J Ophthalmol 2020;68:2572-2574. https://doi.org/10.4103/ijo.IJO_2575_20
  • 13. Montesel A, Bucolo C, Mouvet V, Moret E, Eandi CM. Case report: central retinal artery occlusion in a COVID-19 patient. Front Pharmacol 2020;11:588384. https://doi.org/10.3389/fphar.2020.588384
  • 14. Ucar F, Cetinkaya S. Central retinal artery occlusion in a patient who contracted COVID-19 and review of similar cases. BMJ Case Rep 2021;14:e244181. https://doi.org/10.1136/bcr-2021-244181
  • 15. Bapaye MM, Nair AG, Bapaye CM, Bapaye MM, Shukla JJ. Simultaneous bilateral central retinal artery occlusion following COVID-19 infection. Ocul Immunol Inflamm 2021;29:671-674. https://doi.org/10.1080/09273948.2021.1891262
  • 16. Been Sayeed SKJ, Chandra Das S, Mahmud R, Moniruzzaman M, Rahman MM. Acute ıschemic stroke with central retinal artery occlusion as a rare presentation of COVID-19 disease. Been Sayeed SKJ, Chandra Das S, Mahmud R, Moniruzzaman M, Rahman MM. Cureus 2021;13:e17469. https://doi.org/10.7759/cureus.17469
  • 17. Oronsky B, Larson C, Hammond TC, et al. A review of Persistent Post-COVID Syndrome (PPCS). Clin Rev Allergy Immunol 2021:1-9. https://doi.org/10.1007/s12016-021-08848-3
  • 18. Chippa V, Aleem A, Anjum F. Post acute coronavirus (COVID-19) syndrome. 2021 Oct 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. PMID: 34033370
  • 19. Wolffsohn JS, Arita R, Chalmers R, et al. TFOS DEWS II diagnostic methodology report. Ocul Surf 2017;15:539-574. https://doi.org/10.1016/j.jtos.2017.05.001
  • 20. Wang MTM, Muntz A, Lim J, et al. Ageing and the natural history of dry eye disease: a prospective registry-based cross-sectional study. Ocul Surf 2020;18:736-741. https://doi.org/10.1016/j.jtos.2020.07.003
  • 21. Zhou Y, Zeng Y, Tong Y, Chen C. Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva. MedRxiv 2020. https://doi.org/10.1101/2020.02.11.20021956
  • 22. Chen L, Liu M, Zhang Z, et al. Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease. Br J Ophthalmol. 2020;bjophthalmol-2020-316304. doi:10.1136/bjophthalmol-2020-316304
  • 23. Lin L, Li TS. [Interpretation of "Guidelines for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infection by the National Health Commission (Trial Version 5)"]. Zhonghua Yi Xue Za Zhi 2020;100:e001. https://doi.org/10.3760/cma.j.issn.0376-2491.2020.0001
  • 24. Deng W, Bao L, Gao H, et al. Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in rhesus macaques. Nat Commun 2020;11:4400. https://doi.org/10.1038/s41467-020-18149-6
  • 25. Bertoli F, Veritti D, Danese C, et al. Ocular findings in COVID-19 patients: a review of direct manifestations and indirect effects on the eye.J Ophthalmol 2020;2020:4827304. https://doi.org/10.1155/2020/4827304
  • 26. Dobesh PP, Trujillo TC. Coagulopathy, Venous Thromboembolism, and Anticoagulation in Patients with COVID-19.Pharmacotherapy. 2020 Nov;40(11):1130-1151. doi: 10.1002/phar.2465. Review.
  • 27. Nannoni S, de Groot R, Bell S, Markus HS. Stroke in COVID-19: A systematic review and meta-analysis.Int J Stroke. 2021 Feb;16(2):137-149. doi: 10.1177/1747493020972922.
  • 28. Foster KJ, Jauregui E, Tajudeen B, Bishehsari F, Mahdavinia M. Smell loss is a prognostic factor for lower severity of coronavirus disease 2019. Ann Allergy Asthma Immunol 2020;125:481-483. https://doi.org/10.1016/j.anai.2020.07.023
  • 29. Talavera B, García Azorín D, Martínez Pías E, et al. Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci 2020;419:117163. https://doi.org/10.1016/j.jns.2020.117163
  • 30. Renaud M, Thibault C, Le Normand F, et al. Clinical outcomes for patients with anosmia 1 year after COVID-19 diagnosis. JAMA Netw Open 2021;4:e2115352. https://doi.org/10.1001/jamanetworkopen.2021.15352
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Ophthalmology
Journal Section Research Article
Authors

Semra Acer 0000-0002-4956-3774

Publication Date April 1, 2022
Submission Date January 28, 2022
Acceptance Date February 11, 2022
Published in Issue Year 2022

Cite

AMA Acer S. Koronavirüs 19 hastalığı ve kuru göz. Pam Tıp Derg. April 2022;15(2):355-360. doi:10.31362/patd.1064600
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