İnflamatuar fibroid poliplerin histopatolojik özellikleri ve kanser gelişme riski: bir vaka serisi

Year 2023, , 476 - 485, 01.07.2023

Erdem Çomut , Yeliz Arman Karakaya , Mustafa Çelik , Neşe Demirkan

https://doi.org/10.31362/patd.1270475

Abstract

Amaç: İnflamatuar fibroid polip (IFP) gastrointestinal sistemde görülür. Çoğu vakada PDGFRA geninde somatik mutasyonlar gözlenmiş ve bu antitenin gerçek neoplastik kökeni anlaşılmıştır. Benign mezenkimal bir tümördür ve nadiren tekrarlar. Çalışmanın amacı, IFP olgularımızın histopatolojik özelliklerini ortaya koymak ve kanser riskini araştırmaktır.
Gereç ve yöntem: 2012-2022 yılları arasında IFP olarak bildirilen hastaların (n=12) retrospektif klinikopatolojik analizini gerçekleştirdik. Olguların formaline fikse, parafine gömülü ve hematoksilen-eozin (H&E) boyalı preparatları iki patolog tarafından mikroskobik olarak yeniden incelendi.
Bulgular: Tüm hastalar yetişkin olup yaşları 30 ile 85 arasında değişmekteydi. Erkek/kadın oranı 1:2 idi. Bir polip ince bağırsakta, biri kolonda ve diğerleri midede lokalizeydi. Histolojik olarak, IFP'lere eşlik eden hiperplastik epitelyal değişiklikler (7/12), düşük dereceli (3/12) ve yüksek dereceli displazi (1/12) görüldü. Bir vakada ise erken gastrik adenokarsinom gelişmişti.
Sonuç: IFP benign bir mezenkimal tümör gibi görünsede, bu lezyona displazi ve nadiren karsinomun eşlik edebileceği akılda tutulmalıdır. IFP ile ilişkili displazi ve karsinom gelişim mekanizmalarını aydınlatmak için daha geniş vaka serilerine ihtiyaç vardır.

Keywords

İnflamatuar fibroid polip, gastrointestinal, displazi, karsinom, histopatoloji

Histopathologic features of inflammatory fibroid polyps and risk of cancer development: a case series

Abstract

Purpose: Inflammatory fibroid polyp (IFP) is seen in the gastrointestinal tract. In most cases, somatic mutations in PDGFRA gene were observed and the true neoplastic origin of this entity was understood. It is a benign mesenchymal tumor and rarely recurs. The aim of the study was to reveal the histopathologic features of our IFP cases and to investigate the risk of cancer in one case.
Materials and methods: We performed a retrospective clinicopathological analysis of patients (n=12) who were reported as IFP between 2012 and 2022. Formalin-fixed, paraffin-embedded and hematoxylin-eosin (H&E)- stained slides of the cases were re-examined by two pathologists microscopically.
Results: All patients were adults and ranged in age from 30 to 85. Male to female ratio was 1:2. One polyp was localized in small intestine, one in colon, and the others in stomach. Histologically, there were hyperplastic epithelial changes (7/12), low-grade (3/12), and high-grade dysplasia (1/12) accompanying IFPs. One case was associated with early gastric adenocarcinoma.
Discussion: Although IFP appears as a benign mesenchymal tumor, it should be kept in mind that dysplasia and rarely carcinoma may accompany this lesion. Larger case series are needed to elucidate the mechanisms of dysplasia and carcinoma development associated with IFP.

Keywords

Inflammatory fibroid polyp, gastrointestinal, dysplasia, carcinoma, histopathology

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