Pediatrik ve genç erişkinlerde böbrek nakli: tek merkez deneyimi

Year 2023, , 674 - 681, 01.10.2023

Utku Ozgen , Murat Özban , İlknur Hatice Akbudak , Selcuk Yuksel , İlknur Girişgen , Muhammed Raşid Aykota , Tülay Becerir , Ergun Mete , Neslihan Yılmaz , Ezgi Doğa Yoran , Osman Uzunlu , Mevlüt Çeri , Onur Birsen , Çağatay Aydın

https://doi.org/10.31362/patd.1343201

Abstract

Amaç: Pediatrik böbrek nakli, dünya çapında son dönem böbrek hastalığı (SDBY) olan çocuklarda tercih edilen en konforlu böbrek replasman tedavilerinden biridir. Donör seçimi ve alıcıda altta yatan böbrek yetmezliğine neden olan sebebin ortaya konması ve tedavinin bireyselleştirilmesi, greft sağkalımı için belirleyici faktörlerdir.ve Bu çalışmanın amacı elde ettiğimiz sonuçları sunmaktır.
Gereç ve yöntem: Bu tek merkezli, retrospektif çalışma Pamukkale Üniversitesi Tıp Fakültesi Organ Nakil Merkezi'nde yapılmıştır. Pediatrik böbrek nakilleri, Aralık 2014 ile Kasım 2019 arasında 11 hastaya uygulandı.
Bulgular: İlk diyaliz seansının başlangıcından transplantasyona kadar geçen ortalama süre 40,2 aydı ve iki hastaya önleyici olarak transplantasyon yapıldı. Canlı vericili ve kadavra vericili transplantlarının ortalama yaşı sırasıyla 41,6 ve 17,1 idi. Bu durum ülkemizde kadavra organ bağışında 18 yaş altı bağışçıların sadece 18 yaş altı bağışçıların bekleme listesine kaydedilmesine bağlanmıştır.
Sonuç: Çalışmamız indüksiyon tedavisi için basiliximab kullanan hastaların anti-timosit globülin (ATG) kullanan hastalara göre enfeksiyon açısından daha avantajlı olduğunu göstermiştir.

Keywords

Basiliksimab, ATG, Pediatrik böbrek nakli

Kidney transplantation in pediatric and young adults: a single - center experience

Abstract

Purpose: Pediatric kidney transplant (PKTx) is one of the most comfortable renal replacement therapies preferred in children with end-stage renal disease (ESRD) worldwide. Donor selection and identification of the underlying cause of renal failure in the recipient and individualisation of treatment are decisive factors for graft survival. The aim of this study is to present our results.
Materials and methods: This single-center, retrospective study was conducted at Pamukkale University, Faculty of Medicine, Organ Transplantation Center. The PKTx was performed in 11 patients between December 2014 and November 2019.
Results: The mean time from the beginning of the first dialysis session to transplantation was 40.2 months, and two patients were transplanted preemptively. The mean age of LD and DD transplants was 41.6 years and 17.1 years, respectively. This was attributed to the fact that, in the donation of cadaveric organs, donors under the age of 18 years are only registered for the waiting list for the recipients under the age of 18 years in our country.
Conclusion: Our study showed that patients who used basiliximab for induction treatment were more advantageous in terms of infections than patients using anti-thymocyte globulin (ATG).

Keywords

Basiliximab, ATG, pediatric transplantation

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