Does vitamin D deficiency affect ventricular repolarization in the elderly?

Abstract

Purpose: In this study, we aimed to establish if vitamin D deficiency interacts with the electrocardiographic indices of abnormal ventricular repolarization in elderly patients. Material and methods: 138 patients were divided into three groups: patients with vitamin D deficiency, patients with vitamin D insufficiency, and patients with adequate vitamin D levels. 12-lead electrocardiography and laboratory data were collected. Results: The resting heart rate, PR interval, Tp-e interval, QRS duration, Tp-e/QTc, QT dispersion, and Tp-e dispersion were similar among the groups. However, the QTc interval was significantly prolonged in patients with vitamin D deficiency when compared to patients with sufficient vitamin D levels. Vitamin D level was found as the only independent predictor of the QTc interval. The cut-off value of Vitamin D level determining the significant prolongation of QTc interval was found to be 20 ng/ml on ROC analysis (Area Under Curve: 0.629±0.051 (95% CI: 0.530-0.728, p=0.013). Conclusion: Low vitamin D levels are related to QTc prolongation in the elderly. Vitamin D-deficient elderly patients may benefit from routine ECG screening. Timely diagnosis and treatment of vitamin D deficiency may aid in reducing the rate of arrhythmias in this patient population.

Keywords

• Vitamin D deficiency
• elderly
• ventricular repolarization

D vitamini eksikliği yaşlılarda ventriküler repolarizasyonu etkiliyor mu?

Abstract

Amaç: Bu çalışmanın amacı, D vitamini eksikliğinin yaşlı hastalarda anormal ventriküler repolarizasyonun elektrokardiyografik indeksleri ile ilişkili olup olmadığını belirlemektir. Gereç ve yöntem: 138 hasta üç gruba ayrıldı: D vitamini eksikliği olan hastalar, D vitamini yetersizliği olan hastalar ve yeterli D vitamini düzeyine sahip hastalar. 12 derivasyonlu elektrokardiyografi ve laboratuvar verileri toplandı. Bulgular: İstirahat kalp hızı, PR aralığı, QRS süresi, QTd ve Tp-e dispersiyonu gruplar arasında benzerdi. Ancak, D vitamini eksikliği olan hastalarda QTc aralığı, D vitamini düzeyi yeterli olan hastalara kıyasla anlamlı derecede uzamıştı. D vitamini düzeyi QTc aralığının tek bağımsız belirleyicisi olarak bulundu. ROC analizinde QTc aralığında anlamlı uzamayı belirleyen D vitamini düzeyinin eşik değeri 20 ng/ml olarak bulundu (Eğri Altındaki Alan: 0,629±0,051 (%95 GA: 0,530-0,728, p=0,013). Sonuç: Düşük D vitamini düzeyleri yaşlılarda QTc uzaması ile ilişkilidir. D vitamini eksikliği olan yaşlı hastalar rutin EKG taramasından fayda görebilir. D vitamini eksikliğinin zamanında teşhis ve tedavisi, bu hasta popülasyonunda aritmi oranını azaltmaya yardımcı olabilir.

Keywords

• D vitamini eksikliği
• yaşlılık
• ventriküler repolarizasyon

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