Histological structure and functional properties of the tunica albuginea of the ovary

Hale Yetgin; Murat Serkant Ünal; Cihan Kabukçu; Ahmet Çevik Tufan

doi:10.31362/patd.1467619

TR EN

Ovaryum tunika albugineasının histolojik yapısı ve fonksiyonel özellikleri

Abstract

Ovaryumda yüzey epitelinin hemen altında dokuya beyaz rengini veren, sıkı düzensiz bir bağ doku yapısında olan ve içinde fibroblast hücrelerini içeren tunika albuginea bulunur. Çevresel etkenlere daha dirençli olan, az sayıda hücre içeren ve kollajen liflerden zengin olan tunika albuginea preantral foliküllerin nişi olarak gözlenmektedir. Kollajen lifleri oluşturan fibroblastların salgıladıkları parakrin faktörlerle ve sitokinlerle foliküllerin gelişimlerini sağladıkları ve besleyici hücre tabakası gibi fonksiyon gördükleri izlenmiştir. Graaf folikülün korpus luteumu oluşturmasından sonra ise hemen bitişiğindeki tunika albugineadaki fibroblastların prolifere olduğu ve bu yapının kalınlığının arttığı izlenmiştir. Ratlarda oluşan korpus luteum yapıları nedeniyle tunika albuginea sık sık yenilenmeye uğramaktadır. Korpus luteum oluştuğu zaman bitişiğindeki tunika albugineada yeni kapillerler ve venüller meydana gelmektedir. Bu yapı; hücrelerin kemik iliğinden, damarlarla ovaryuma migrasyonlarının araştırılması için uygun bir model olabilir. Mezenkimal hücrelerin ve pluripotent kök hücre özelliği gösteren çok küçük embriyonik benzeri kök hücrelerin (VSELs) vasküler yapılar aracılığıyla kemik iliğinden tunika albugineaya gelebileceği ve ovaryumda bulundukları daha önce gösterilen bu hücrelerin kaynağının kemik iliği olabileceği ileri sürülebilir. Bu derlemedeki amacımız tunika albugineanın foliküllerin gelişimine ve ovaryumun dinamik yapısı üzerine olan etkilerini incelemektir.

Keywords

Ovaryum, tunika albuginea, kollajen lifler, folikül, korpus luteum

Histological structure and functional properties of the tunica albuginea of the ovary

Abstract

Just below the surface epithelium of the ovary is the tunica albuginea, which is a tight irregular connective tissue structure that gives the tissue its white color and contains fibroblast cells. Tunica albuginea, which is more resistant to environmental factors, contains fewer cells and is rich in collagen fibers, is observed as the niche of preantral follicles. It has been observed that fibroblasts forming collagen fibers provide the development of follicles with the paracrine factors and cytokines they secrete and function as a nourishing cell layer. After the graaf follicle forms the corpus luteum, fibroblasts in the adjacent tunica albuginea proliferate and the thickness of this structure increases. The tunica albuginea undergoes frequent renewal due to the corpus luteum structures formed in rats. When the corpus luteum is formed, new capillaries and venules are formed in the adjacent tunica albuginea. This structure may be a suitable model for investigating the migration of cells from the bone marrow to the ovary via vessels. It can be suggested that mesenchymal cells and very small embryonic-like stem cells (VSELs), which show pluripotent stem cell characteristics, may migrate from the bone marrow to the tunica albuginea through vascular structures and that the bone marrow may be the source of these cells, which have been previously shown to be present in the ovary. The aim of this review is to examine the effects of the tunica albuginea on the development of follicles and the dynamic structure of the ovary.

Keywords

Ovary, tunica albuginea, collagen fibers, follicle, corpus luteum

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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Review

Authors

Hale Yetgin ^*
0009-0005-9153-8221
Türkiye

Murat Serkant Ünal
0000-0003-1992-7909
Türkiye

Cihan Kabukçu
0000-0003-3331-5714
Türkiye

Ahmet Çevik Tufan
0000-0002-5920-0475
Türkiye

Early Pub Date

September 10, 2024

Publication Date

April 1, 2025

Submission Date

April 17, 2024

Acceptance Date

July 2, 2024

Published in Issue

Year 2025 Volume: 18 Number: 2

DOI

https://doi.org/10.31362/patd.1467619

IZ

https://izlik.org/JA42TJ34GB

APA

Yetgin, H., Ünal, M. S., Kabukçu, C., & Tufan, A. Ç. (2025). Histological structure and functional properties of the tunica albuginea of the ovary. Pamukkale Medical Journal, 18(2), 460-473. https://doi.org/10.31362/patd.1467619

AMA

1.Yetgin H, Ünal MS, Kabukçu C, Tufan AÇ. Histological structure and functional properties of the tunica albuginea of the ovary. Pam Med J. 2025;18(2):460-473. doi:10.31362/patd.1467619

Chicago

Yetgin, Hale, Murat Serkant Ünal, Cihan Kabukçu, and Ahmet Çevik Tufan. 2025. “Histological Structure and Functional Properties of the Tunica Albuginea of the Ovary”. Pamukkale Medical Journal 18 (2): 460-73. https://doi.org/10.31362/patd.1467619.

EndNote

Yetgin H, Ünal MS, Kabukçu C, Tufan AÇ (April 1, 2025) Histological structure and functional properties of the tunica albuginea of the ovary. Pamukkale Medical Journal 18 2 460–473.

IEEE

[1]H. Yetgin, M. S. Ünal, C. Kabukçu, and A. Ç. Tufan, “Histological structure and functional properties of the tunica albuginea of the ovary”, Pam Med J, vol. 18, no. 2, pp. 460–473, Apr. 2025, doi: 10.31362/patd.1467619.

ISNAD

Yetgin, Hale - Ünal, Murat Serkant - Kabukçu, Cihan - Tufan, Ahmet Çevik. “Histological Structure and Functional Properties of the Tunica Albuginea of the Ovary”. Pamukkale Medical Journal 18/2 (April 1, 2025): 460-473. https://doi.org/10.31362/patd.1467619.

JAMA

1.Yetgin H, Ünal MS, Kabukçu C, Tufan AÇ. Histological structure and functional properties of the tunica albuginea of the ovary. Pam Med J. 2025;18:460–473.

MLA

Yetgin, Hale, et al. “Histological Structure and Functional Properties of the Tunica Albuginea of the Ovary”. Pamukkale Medical Journal, vol. 18, no. 2, Apr. 2025, pp. 460-73, doi:10.31362/patd.1467619.

Vancouver

1.Hale Yetgin, Murat Serkant Ünal, Cihan Kabukçu, Ahmet Çevik Tufan. Histological structure and functional properties of the tunica albuginea of the ovary. Pam Med J. 2025 Apr. 1;18(2):460-73. doi:10.31362/patd.1467619

Pamukkale Medical Journal is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC).

Ovaryum tunika albugineasının histolojik yapısı ve fonksiyonel özellikleri

Abstract

Keywords

Histological structure and functional properties of the tunica albuginea of the ovary

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Early Pub Date

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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