Çocuk yoğun bakım ünitesinde mortalite skorlama sistemlerinin güvenilirliği ve etkinliğinin karşılaştırılması
Year 2024,
, 664 - 673, 09.10.2024
Hatice Feray Arı
,
Salim Reşitoğlu
,
Mehmet Akif Tuncel
,
Mahmut Can Şerbetçi
Abstract
Amaç: Çocuk yoğun bakım ünitesinde (ÇYBÜ) yüksek mortalite riski önemli bir sorundur. Mortalite riskinin
erken ön görülmesi için çeşitli risk skorlama sistemleri vardır. Pediatric Risk of Mortality (PRISM), Pediatric
Index of Mortality (PIM), Pediatric Logistic Organ Dysfunction (PELOD) ve Pediatric Sequential Organ Failure
Assessment (PSOFA) yaygın olarak kullanılmaktadır. Çalışmamızın amacı, PRISM III, PIM3, PELOD-2 ve
PSOFA’ nın mortaliteyi öngörmedeki gücünün ve etkinliğinin değerlendirilmesidir.
Gereç ve yöntem: Tek merkezli retrospektif çalışmada Nisan-Aralık 2021 tarihleri arasında ÇYBÜ'de yatan 1 ay-
18 yaş arası tüm hastalar incelendi. Elektronik kayıtlarından demografik özellikleri, klinik öyküleri ve morbidite/
mortalite durumu araştırıldı.
Bulgular: Çalışmaya ÇYBÜ yatış süresi 56,73±105,95 gün olan 300 hasta dahil edildi. Çalışma sonunda 56
(%18,7) hasta vefat etmişti. Tüm skorlama sistemleri ve mortalite korelasyonları istatistiksel olarak anlamlı
bulundu (p<0,0001). Mortaliteyi öngörmede başarı oranları, duyarlılık ve özgüllük açısından incelendiğinde
başarılı olma oranı sırasıyla PRISM III, PELOD-2, PSOFA ve PIM 3 idi.
Sonuç: Dört mortalite skorlama sistemini karşılaştıran herhangi bir çalışmanın bulunmaması, kritik hastalığı
olan çocuklarda erken tanı ve hızlı müdahale için skorlama sistemleri önemini artırmaktadır. Çalışmamıza
dayanarak, PRISM III verilerinin heterojen hasta popülasyonumuzda mortalite ön gördürme için daha güvenilir
olduğu bulunmuştur.
References
- 1. Brady AR, Harrison D, Black S, et al. Assessment and optimization of mortality prediction tools for admissions to pediatric intensive care in the United Kingdom. Pediatrics 2006;117:733-742. https://doi.org/10.1542/peds.2005-1853
- 2. Van Keulen JG, Polderman KH, Gemke RJBJ. Reliability of PRISM and PIM scores in paediatric intensive care. Arch Dis Child 2005;90:211-214. https://doi.org/10.1136/adc.2003.046722
- 3. Qureshi AU, Ali AS, Ahmad TM. Comparison of three prognostic scores (PRISM, PELOD and PIM 2) at pediatric intensive care unit under Pakistani circumstances. J Ayub Med Coll Abbottabad 2007;19:49-53.
- 4. Wang JN, Wu JM, Chen YJ. Validity of the updated pediatric risk of mortality score (PRISM III) in predicting the probability of mortality in a pediatric intensive care unit. Acta Paediatr Taiwan 2001;42:333-337.
- 5. Singer M, Deutschman CS, Seymour CW, et al. The third ınternational consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315:801-810. https://doi.org/10.1001/jama.2016.0287
- 6. Pollack MM, Patel KM, Ruttimann UE. PRISM III: An updated pediatric risk of mortality score. Crit Care Med 1996;24:743-752. https://doi.org/10.1097/00003246-199605000-00004
- 7. Leteurtre S, Martinot A, Duhamel A, et al. Development of a pediatric multiple organ dysfunctionscore: use of two strategies. Med Decis Making 1999;19:399-410. https://doi.org/10.1177/0272989X9901900408
- 8. Leteurtre S, Duhamel A, Salleron J, et al. PELOD-2: an update of the PEdiatric logisticorgan dysfunction score. Crit Care Med 2013;41:1761-1773. https://doi.org/10.1097/CCM.0b013e31828a2bbd
- 9. Dragsted L, Jorgensen J, Jensen NH, et al. Interhospital comparisons of patient outcome from intensive care: importance of lead-time bias. Crit Care Med 1989;17:418-422. https://doi.org/10.1097/00003246-198905000-00008
- 10. Slater A, Shann F, Pearson G; Paediatric Index of Mortality (PIM) Study Group. PIM2: a revised version of the paediatric index of mortality. Intensive Care Med 2003;29:278-285. https://doi.org/10.1007/s00134-002-1601-2
- 11. Matics TJ, Sanchez Pinto LN. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the sepsis-3 definitions in critically Ill children. JAMA Pediatr 2017;171:172-352. https://doi.org/10.1001/jamapediatrics.2017.2352
- 12. Tekerek NU, Akyildiz BN. Prognosis of patients in a pediatric ıntensive care unit of a tertiary care center. Turkish J Pediatr Dis 2017;11:221-225. https://doi.org/10.12956/tjpd.2017.269
- 13. Demirkol D, Karabocuoglu M. Criteria of admission and discharge in pediatric care units. Turk Arch Pediatr 2010;45:82-84. https://doi.org/10.4274/tpa.45.82
- 14. Koroglu TF, Bayrakci B, Dursun O, Kendirli T, Yıldızdas D, Karabocuoglu M. A guide for pediatric intensive care units: propositions from pediatric emergency medicine and intensive care society. Turk Arch Pediatr 2006;41:139-145.
- 15. Asilioglu N, Kot H. Çocuk yoğun bakım ünitesine yatan olguların değerlendirilmesi ve sonuçları. Turkiye Klinikleri J Pediatr 2011;20:10-15.
- 16. Oz O, Bayraktar S, Elevli M, et al. Bir eğitim ve araştırma hastanesi çocuk yoğun bakım ünitesine yatan hastaların değerlendirilimesi. CAYD 2015;2:65-70.
- 17. Orhan MF, Yakut HI, Ikiz MA. Çocuk yoğun bakım ünitesinde 2 yıl içinde yatan 938 olgumuzun değerlendirilmesi. Türkiye Çocuk Hast Derg 2012;6:228-231.
- 18. Konca C, Tekin M, Karakoc F, Turgut M. Çocuk yoğun bakım ünitesinde yatan 770 hastanın değerlendirilmesi: tek merkez deneyimi. Türkiye Çocuk Hast Derg 2015;2:90-95. https://doi.org/10.12956/tjpd.2015.120
- 19. Poyrazoglu H, Dursun I, Gunes T, et al. Çocuk yoğun bakım ünitesine yatan olguların değerlendirimesi ve sonuçları. Erciyes Tıp Dergisi 2008;30:232-237.
- 20. Khilnani P, Sarma D, Singh R, et al. Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Indian J Pediatr 2004;71:587-591. https://doi.org/10.1007/BF02724117
- 21. Goncalves JP, Severo M, Rocha C, Jardim J, Mota T, Ribeiro A. Performance of PRISM III and PELOD-2 scores in a pediatric intensive care unit. Eur J Pediatr 2015;174:1305-1310. https://doi.org/10.1007/s00431-015-2533-5
- 22. Gonzalez Luis G, Pons M, Cambra FJ, Martin JM, Palomeque A. Use of the Pediatric Risk of Mortality Score as predictor of death and serious neurologic damage in children after submersion. Pediatr Emerg Care 2001;17:405-409. https://doi.org/10.1097/00006565-200112000-00002
- 23. Moons KGM, Altman DG, Vergouwe Y, Royston P. Prognosis and prognostic research: application and impact of prognostic models in clinical practice. BMJ 2009;338:b606. https://doi.org/10.1136/bmj.b606
- 24. El Mashad GM, El Mekkawy MS, Zayan MH. Paediatric sequential organ failure assessment (pSOFA) score: a new mortality prediction score in the paediatric intensive care unit. An Pediatr 2020;92:277-285. https://doi.org/10.1016/j.anpedi.2019.05.018
Comparison between mortality scoring systems in pediatric intensive care unit reliability and effectiveness
Year 2024,
, 664 - 673, 09.10.2024
Hatice Feray Arı
,
Salim Reşitoğlu
,
Mehmet Akif Tuncel
,
Mahmut Can Şerbetçi
Abstract
Purpose: In pediatric intensive care unit (PICU), high mortality risk is a significant issue. Risk adjustment tools
are in place for early estimation of mortality risk. Pediatric Risk of Mortality (PRISM), Pediatric Index of Mortality
(PIM), Pediatric Logistic Organ Dysfunction (PELOD) and Pediatric Sequential Organ Failure Assessment
(PSOFA) are commonly used. The aim of this study was to evaluate the predictive performance of mortality
using PRISM III, PIM3, PELOD-2, and PSOFA.
Materials and methods: This retrospective single-center study analysed patients aged between 1 month-18
years who were treated in PICU for various diseases between April and December 2021. Their electronic
records were retrospectively examined for demographic characteristics, medical and clinical expectations, and
morbidity/mortality.
Results: The study included 300 patients with a hospitalization period of 56.73±105.95 days. At the end of the
study, 56 (18.7%) patients had died. All scoring systems and mortality correlations were statistically significant
(p<0.0001). The predictive success rates for mortality, ranked from best to worst, were PRISM III, PELOD-2,
PSOFA, and PIM 3, respectively, in terms of sensitivity and specificity.
Conclusion: The absence of any studies comparing these four mortality scoring systems adds to their
importance for early recognition and rapid intervention in critically ill children. Based on our study, PRISM III
data has been found to be more reliable in this heterogeneous population.
Ethical Statement
Ethics: The ethics committee approval for the study was obtained Harran University Clinical Research Ethics Committee (22/01/12).
Supporting Institution
yok
Thanks
Acknowledgments: The authors express gratitude to the pediatric intensive care team who participated in the treatment and follow-up of the patients included in the study.
References
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- 2. Van Keulen JG, Polderman KH, Gemke RJBJ. Reliability of PRISM and PIM scores in paediatric intensive care. Arch Dis Child 2005;90:211-214. https://doi.org/10.1136/adc.2003.046722
- 3. Qureshi AU, Ali AS, Ahmad TM. Comparison of three prognostic scores (PRISM, PELOD and PIM 2) at pediatric intensive care unit under Pakistani circumstances. J Ayub Med Coll Abbottabad 2007;19:49-53.
- 4. Wang JN, Wu JM, Chen YJ. Validity of the updated pediatric risk of mortality score (PRISM III) in predicting the probability of mortality in a pediatric intensive care unit. Acta Paediatr Taiwan 2001;42:333-337.
- 5. Singer M, Deutschman CS, Seymour CW, et al. The third ınternational consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 2016;315:801-810. https://doi.org/10.1001/jama.2016.0287
- 6. Pollack MM, Patel KM, Ruttimann UE. PRISM III: An updated pediatric risk of mortality score. Crit Care Med 1996;24:743-752. https://doi.org/10.1097/00003246-199605000-00004
- 7. Leteurtre S, Martinot A, Duhamel A, et al. Development of a pediatric multiple organ dysfunctionscore: use of two strategies. Med Decis Making 1999;19:399-410. https://doi.org/10.1177/0272989X9901900408
- 8. Leteurtre S, Duhamel A, Salleron J, et al. PELOD-2: an update of the PEdiatric logisticorgan dysfunction score. Crit Care Med 2013;41:1761-1773. https://doi.org/10.1097/CCM.0b013e31828a2bbd
- 9. Dragsted L, Jorgensen J, Jensen NH, et al. Interhospital comparisons of patient outcome from intensive care: importance of lead-time bias. Crit Care Med 1989;17:418-422. https://doi.org/10.1097/00003246-198905000-00008
- 10. Slater A, Shann F, Pearson G; Paediatric Index of Mortality (PIM) Study Group. PIM2: a revised version of the paediatric index of mortality. Intensive Care Med 2003;29:278-285. https://doi.org/10.1007/s00134-002-1601-2
- 11. Matics TJ, Sanchez Pinto LN. Adaptation and validation of a pediatric sequential organ failure assessment score and evaluation of the sepsis-3 definitions in critically Ill children. JAMA Pediatr 2017;171:172-352. https://doi.org/10.1001/jamapediatrics.2017.2352
- 12. Tekerek NU, Akyildiz BN. Prognosis of patients in a pediatric ıntensive care unit of a tertiary care center. Turkish J Pediatr Dis 2017;11:221-225. https://doi.org/10.12956/tjpd.2017.269
- 13. Demirkol D, Karabocuoglu M. Criteria of admission and discharge in pediatric care units. Turk Arch Pediatr 2010;45:82-84. https://doi.org/10.4274/tpa.45.82
- 14. Koroglu TF, Bayrakci B, Dursun O, Kendirli T, Yıldızdas D, Karabocuoglu M. A guide for pediatric intensive care units: propositions from pediatric emergency medicine and intensive care society. Turk Arch Pediatr 2006;41:139-145.
- 15. Asilioglu N, Kot H. Çocuk yoğun bakım ünitesine yatan olguların değerlendirilmesi ve sonuçları. Turkiye Klinikleri J Pediatr 2011;20:10-15.
- 16. Oz O, Bayraktar S, Elevli M, et al. Bir eğitim ve araştırma hastanesi çocuk yoğun bakım ünitesine yatan hastaların değerlendirilimesi. CAYD 2015;2:65-70.
- 17. Orhan MF, Yakut HI, Ikiz MA. Çocuk yoğun bakım ünitesinde 2 yıl içinde yatan 938 olgumuzun değerlendirilmesi. Türkiye Çocuk Hast Derg 2012;6:228-231.
- 18. Konca C, Tekin M, Karakoc F, Turgut M. Çocuk yoğun bakım ünitesinde yatan 770 hastanın değerlendirilmesi: tek merkez deneyimi. Türkiye Çocuk Hast Derg 2015;2:90-95. https://doi.org/10.12956/tjpd.2015.120
- 19. Poyrazoglu H, Dursun I, Gunes T, et al. Çocuk yoğun bakım ünitesine yatan olguların değerlendirimesi ve sonuçları. Erciyes Tıp Dergisi 2008;30:232-237.
- 20. Khilnani P, Sarma D, Singh R, et al. Demographic profile and outcome analysis of a tertiary level pediatric intensive care unit. Indian J Pediatr 2004;71:587-591. https://doi.org/10.1007/BF02724117
- 21. Goncalves JP, Severo M, Rocha C, Jardim J, Mota T, Ribeiro A. Performance of PRISM III and PELOD-2 scores in a pediatric intensive care unit. Eur J Pediatr 2015;174:1305-1310. https://doi.org/10.1007/s00431-015-2533-5
- 22. Gonzalez Luis G, Pons M, Cambra FJ, Martin JM, Palomeque A. Use of the Pediatric Risk of Mortality Score as predictor of death and serious neurologic damage in children after submersion. Pediatr Emerg Care 2001;17:405-409. https://doi.org/10.1097/00006565-200112000-00002
- 23. Moons KGM, Altman DG, Vergouwe Y, Royston P. Prognosis and prognostic research: application and impact of prognostic models in clinical practice. BMJ 2009;338:b606. https://doi.org/10.1136/bmj.b606
- 24. El Mashad GM, El Mekkawy MS, Zayan MH. Paediatric sequential organ failure assessment (pSOFA) score: a new mortality prediction score in the paediatric intensive care unit. An Pediatr 2020;92:277-285. https://doi.org/10.1016/j.anpedi.2019.05.018