The relationship between systemic immune inflammation index and disease activity in ankylosing spondylitis patients

Abstract

Purpose: This study aimed to investigate the relationship between the systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and disease activity and functional status in patients with ankylosing spondylitis (AS). Materials and methods: This cross-sectional clinical study included a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics. Demographic data and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, and lymphocyte counts, mean platelet volume (MPV), red blood cell distribution width (RDW), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were recorded. NLR and PLR values were calculated. The SII was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. Results: The study included 90 AS patients (mean age: 42.9±11.3 years). Positive correlations were observed between SII and CRP (p=0.010, r=0.269) and ESR (p=0.007, r=0.282). No significant correlations were found between SII and BASDAI (p=0.323), BASFI (p=0.124) or BASMI (p=0.673). NLR and PLR values didn’t differ significantly between active and inactive disease groups across all disease activity measures (BASDAI, ASDASCRP, and ASDAS-ESR; NLR: p=0.933, p=0.639, p=0.240; PLR: p=0.708, p=0.858, p=0.351; respectively). There was a significant correlation between SII and Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate (ASDAS-ESR) (rho=0.282, p=0.007). Conclusion: The study suggests that SII correlates positively with CRP and ESR, common inflammatory markers in AS. SII could be a potential marker for assessing inflammation, especially in patients with higher disease activity.

Keywords

• Ankylosing spondylitis
• complete blood count
• inflammation

Ankilozan spondilit hastalarında sistemik immün inflamasyon indeksinin hastalık aktivitesi ile ilişkisi

Abstract

Amaç: Bu çalışma, ankilozan spondilit (AS) hastalarında sistemik immün inflamasyon indeksi (SII), trombositlenfosit oranı (PLR), nötrofil-lenfosit oranı (NLR) ile hastalık aktivitesi ve fonksiyonel durum arasındaki ilişkiyi araştırmayı amaçlamaktadır. Gereç ve yöntem: Bu klinik kesitsel çalışmaya, Modifiye New York Kriterleri’ne göre AS tanısı almış 18- 65 yaş aralığında 90 hasta dahil edildi. Demografik veriler, trombosit, nötrofil, bazofil, eozinofil ve lenfosit sayıları, ortalama trombosit hacmi (MPV), eritrosit dağılım genişliği (RDW), C-reaktif protein (CRP) ve eritrosit sedimantasyon hızı (ESR) gibi laboratuvar parametreleri kaydedildi. NLR, PLR ve SII değerleri hesaplandı. Bulgular: Çalışmaya dahil edilen AS hastalarının yaş ortalamaları 42,9±11,3 yıl idi. SII ile CRP (p=0,010, r=0,269) ve ESR (p=0,007, r=0,282) arasında pozitif korelasyon saptandı. SII ile BASDAI (p=0,323), BASFI (p=0,124) veya BASMI (p=0,673) arasında anlamlı bir ilişki bulunmadı. NLR ve PLR değerleri aktif ve inaktif hastalık grupları arasında anlamlı bir fark göstermedi (BASDAI, ASDAS-CRP ve ASDAS-ESR için sırasıyla; NLR: p=0,933, p=0,639, p=0,240; PLR: p=0,708, p=0,858, p=0,351). SII ile ESR kullanılarak hesaplanan Ankilozan Spondilit Hastalık Aktivite Skoru (ASDAS-ESR) arasında anlamlı bir korelasyon vardı (rho=0,282, p=0,007). Sonuç: Çalışma, SII’nin AS’de yaygın inflamatuar belirteçler olan CRP ve ESR ile pozitif korelasyon gösterdiğini ortaya koymaktadır. SII, özellikle daha yüksek hastalık aktivitesine sahip hastalarda inflamasyonu değerlendirmek için potansiyel bir belirteç olabilir.

Keywords

• Ankilozan spondilit
• tam kan sayımı
• inflamasyon

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