Obezitede depresyonun rolü ve bilişsel işlevler, leptin, ghrelin, nöropeptid Y ilişkisi

Abstract

Amaç: Depresyon ve obezite etyopatogenezinde karşılıklı iki yönlü bir ilişkinin olduğu bilinmektedir. Bu çalışmada, obezite ve depresyon hastalarında serum ghrelin, leptin, nöropeptid Y düzeylerinin, bilişsel işlevlerin ve atipik depresif özelliklerin araştırılması amaçlanmıştır. Nörokimyasal parametreler ve bilişsel işlevler açısından obezite ve depresyon hastalarının benzer özellikler göstereceği ve obez bireylerde atipik depresif özelliklerin yüksek olabileceği beklenmektedir. Gereç ve yöntem: Çalışmaya 56 obez birey, 60 major depresif bozukluklu (MDB) hasta ve 53 sağlıklı kontrol alınmıştır. Sosyodemografik veri formu, Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), Hamilton Anksiyete Ölçeği (HAS), Hollanda Yeme Davranışı Anketi, Yapılandırılmış Görüşme Kılavuzu Mevsimsel Duygudurum Bozukluğu Versiyonu (SIGH-SAD) uygulanmıştır. Bilişsel işlevler Wisconsin Kart Eşleme Testi’nin (WCST) kısa bilgisayar versiyonu Berg’s WCST, Stroop testinin Victoria formu olan Victoria Stroop Test ile değerlendirilmiştir. Serum ghrelin, leptin, nöropeptid Y düzeyleri belirlenmiştir. Bulgular: MDB grubunda depresyon puanları obezite ve sağlıklı kontrol grubuna göre yüksek (p<0,001), MDB ve obezite gruplarında anksiyete puanları benzer (p=0,064) bulundu. SIGH-SAD puan ortalamaları açısından gruplar arasında fark bulunmadı (p=0,989). Gruplar WCST puanları açısından da benzerdi (p>0,05). Stroop testinde gruplar arasında farklılık tespit edildi. Leptin düzeyleri obezite grubunda diğer gruplardan yüksekti (p<0,001), ghrelin (p=0,038) ve nöropeptid Y (p<0,001) düzeyleri ise düşük bulundu. Obez bireylerde ghrelin düzeyleri ile bilişsel işlevler açısından toplam yanlış cevap sayısı arasında negative yönde zayıf düzeyde korelasyon saptandı (r=-0.259 p=0,049). Sonuç: Çalışmamızda obezitede depresif belirtilerin yüksek olmasına karşın atipik depresif özellikler bulunmadığı, gruplar arasında yürütücü işlevlerin benzer olduğu, obezite ve depresyonda nörokimyasal belirtileç düzeylerinin benzer olmadığı belirlenmiştir. Sonuçlarımız obeziteyi atipik depresyon ilişkisini desteklememektedir.

Keywords

• Obezite
• depresyon
• leptin
• ghrelin
• nöropeptid Y

Supporting Institution

Pamukkale Üniversitesi Bilimsel Araştırmaları Koordinasyon Birimi

The role of depression in obesity and the relationship between cognitive functions, leptin, ghrelin, and neuropeptide Y

Abstract

Purpose: It is known that there is a two-way relationship in the etiopathogenesis of depression and obesity. This study aimed to investigate serum ghrelin, leptin, neuropeptide Y levels, cognitive functions, and atypical depressive features in obese and depressed patients. It is expected that obese and depressed patients will show similar features in terms of biochemical parameters and cognitive functions, and atypical depressive features may be high in obese individuals. Materials and methods: The study included 56 obese individuals, 60 patients with major depressive disorder (MDD), and 53 healthy controls (HC). The questionnaires administered included socio-demographic data form, Hamilton Depression Rating Scale, Hamilton Anxiety Scale, Dutch Eating Behaviour Questionnaire, Structured Interview Guide for the Hamilton Depression Rating Scale-Seasonal Affective Disorder Version (SIGH-SAD). Cognitive functions were assessed with short computer version of Wisconsin Card Sorting Test (WCST), Berg’s WCST, Stroop Colour-Word Test-Victoria version. Serum ghrelin, leptin, and neuropeptide Y levels were measured. Results: The depression scores were found higher MDD group than obesity and HC groups (p<0.001) and anxiety scores similar in MDD and obesity groups (p=0.064). The groups had similar mean SIGH-SAD scores (p=0.989). There was no difference between groups in WCST scores (p>0.05). Differences were detected between the groups in the Stroop test. Leptin levels were higher (p<0.001), ghrelin (p=0.038) and neuropeptide Y (p<0.001) levels lower in obesity group compared to MDD and HC. Ghrelin levels negatively correlated with total number of incorrect responses in terms of cognitive functions in obese individuals (r=-0.259 p=0.049). Conclusion: In our study, it was determined that although depressive symptoms were high in obesity, there were no atypical depressive features, executive functions were similar between the groups, and neurochemical marker levels were not similar in obesity and depression. Our results do not support the relationship between obesity and atypical depression.

Keywords

• Obesity
• depression
• leptin
• ghrelin
• neuropeptide Y

Supporting Institution

Scientific Research Projects Coordination Unit of Pamukkale University

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