Levels of integrin, irisin, and anti-Müllerian hormone in polycystic ovary syndrome patients

Abstract

Purpose: The purpose of the study was to find out if there were any notable differences in serum levels of irisin, integrin α4, integrin α5, integrin β2, and anti-Müllerian hormone (AMH) between PCOS patients and healthy women. Material and methods: This case-controlled observational study includes 42 women with PCOS and 42 healthy women of the same age as the control group. Irisin, integrin α4, integrin α5, and integrin β2 levels were measured, along with serum lipid subfractions, fasting serum glucose, fasting insulin, and other hormones (androgens, gonadotropins). Insulin resistance was estimated using the Homeostasis Model Assessment (HOMA-IR). We measured the levels of irisin and integrin (α4, α5, and β2) using an enzyme-linked immunosorbent assay. Results: Women with PCOS had significantly higher levels of irisin, HOMA-IR, AMH, and free androgen index (FAI) than the control group (p=0.0001, 0.0001, and 0.0001, respectively). Integrins (α4, α5, β2) are substantially reduced in women with PCOS (p=0.023, 0.001, and 0.0001, respectively). HOMA-IR scores showed a negative correlation with integrin levels (α4, α5, β2) (r=-0.412 p=0.007, r=-0.468 p=0.002, and r=-0.446 p=0.003, respectively) but a positive correlation with AMH and irisin levels in women with PCOS (r=0.693 p=0.001 and r=0.424 p=0.005, respectively). Conclusion: AMH, irisin, and integrin levels were found to be significantly changed in non-diabetic women with PCOS. We think that the root cause of these changes could be disturbances in energy homeostasis.

Keywords

• Integrin α4
• integrin α5
• integrin β2
• irisin
• polycystic ovary syndrome

Polikistik over sendromlu hastalarda integrin, irisin ve anti-Müllerian hormon düzeyleri

Abstract

Amaç: Çalışmanın amacı, PCOS hastaları ve sağlıklı kadınlar arasında serum irisin, integrin α4, integrin α5, integrin β2 ve anti-Müllerian hormonu (AMH) seviyelerinde belirgin bir fark olup olmadığını bulmaktı. Gereç ve yöntem: Bu vaka kontrollü gözlemsel çalışmaya PCOS'lu 42 kadın ve kontrol grubuyla aynı yaştaki 42 sağlıklı kadın dahil edildi. İrisin, integrin α4, integrin α5 ve integrin β2 seviyeleri, serum lipid alt fraksiyonları, açlık serum glikozu, açlık insülin ve diğer hormonlar (androjenler, gonadotropinler) birlikte ölçüldü. İnsülin direnci, Homeostasis Model Assessment (HOMA-IR) kullanılarak hesaplandı. İrisin ve integrin (α4, α5 ve β2) seviyelerini enzim bağlantılı bir immünosorbent testi kullanarak ölçtük. Bulgular: PCOS'lu kadınlarda irisin, HOMA-IR, AMH ve serbest androjen indeksi (FAI) düzeyleri kontrol grubuna göre önemli ölçüde daha yüksekti (p=0,0001, 0,0001, ve 0,0001, sırasıyla). İntegrinler (α4, α5, β2) PCOS'lu kadınlarda önemli ölçüde azalmıştır (p=0,023, 0,001, ve 0,0001, sırasıyla). HOMA-IR skorları integrin düzeyleriyle (α4, α5, β2) negatif korelasyon gösterirken (r=-0,412 p=0,007, r=-0,468 p=0,002, ve r=-0,446 p=0,003, sırasıyla) PCOS'lu kadınlarda AMH ve irisin düzeyleriyle pozitif korelasyon gösterdi (r=0,693 p=0,001 ve r=0,424 p=0,005, sırasıyla). Sonuç: AMH, irisin ve integrin düzeylerinin PCOS'lu diyabetsiz kadınlarda önemli ölçüde değiştiği bulundu. Bu değişikliklerin temel nedeninin enerji homeostazındaki bozukluklar olabileceğini düşünüyoruz.

Keywords

• İntegrin α4
• integrin α5
• integrin β2
• irisin
• polikistik over sendromu

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