Mitochondrial dysfunction in children with chronic kidney disease

Abstract

Purpose: We aimed to determine serum mitochondrial open reading frame 12S rRNA-c (MOTS-C) levels as an indicator of mitochondrial dysfunction in childhood chronic kidney disease patients and to investigate the relationship of this parameter, which is a metabolic regulatory factor, with renal anemia, hypertension metabolic acidosis and renal osteodystrophy. Materials and methods: The study included 46 children with chronic kidney disease and 46 healthy children of similar age and gender. The patient group was divided into G1-G5 subgroups according to glomerular filtration rate, etiology, renal replacement therapies and the presence of anemia, hypertension, hyperparathyroidism and metabolic acidosis. Data were analyzed using SPSS 25.0 package program. Results: The mean MOTS-C level was 60.47±11.1 ng/ml in patients with chronic kidney disease and 105.2±54.7 ng/ml in healthy children (p=0.001). The MOTS-C level was significantly lower in children with chronic kidney disease. In addition, there was no significant difference between patients who underwent renal transplantation and patients on chronic dialysis or predialysis. MOTS-C levels were significantly lower in patients with hyperparathyroidism and anemia compared to those without. Conclusion: In our study, we demonstrated that mitochondrial damage in children with chronic kidney disease begins even in the early stages, renal osteodystrophy and anemia contribute to this condition, and mitochondrial inflammation persists even after kidney transplantation in these patients.

Keywords

• Mitochondria
• MOTS-C
• children
• chronic kidney disease

Kronik böbrek hastalığı olan çocuklarda mitokondriyal disfonksiyon

Abstract

Amaç: Çocukluk çağı kronik böbrek hastalarında mitokondriyal disfonksiyonun bir göstergesi olarak serum MOTS-C düzeylerini belirlemeyi ve metabolik düzenleyici bir faktör olan bu parametrenin renal anemi, hipertansiyon, metabolik asidoz ve renal osteodistrofi ile ilişkisini araştırmayı amaçladık. Gereç ve yöntem: Çalışmaya kronik böbrek hastalığı olan 46 çocuk ve benzer yaş ve cinsiyette 46 sağlıklı çocuk dahil edildi. Hasta grubu glomerüler filtrasyon hızına göre G1-G5, etiyoloji, renal replasman tedavileri ve anemi, hipertansiyon, hiperparatiroidizm ve metabolik asidoz varlığına göre alt gruplarına ayrıldı. Veriler SPSS 25.0 paket programı kullanılarak analiz edildi. Bulgular: Ortalama MOTS-C düzeyi kronik böbrek hastalığı olanlarda 60,47±11,1 ng/ml iken sağlıklı çocuklarda 105,2±54,7 ng/ml idi (p=0,001). MOTS-C düzeyi kronik böbrek hastalığı olan çocuklarda anlamlı derecede düşüktü. Ayrıca, böbrek nakli yapılan hastalar ile kronik diyaliz veya prediyaliz hastaları arasında anlamlı bir fark yoktu. MOTS-C düzeyleri hiperparatiroidizm ve anemisi olan hastalarda olmayanlara kıyasla anlamlı derecede düşüktü. Sonuç: Çalışmamızda, kronik böbrek hastalığı olan çocuklarda mitokondriyal hasarın erken evrelerde bile başladığını, renal osteodistrofi ve aneminin bu duruma katkıda bulunduğunu ve mitokondriyal inflamasyonun bu hastalarda böbrek naklinden sonra bile devam ettiğini gösterdik.

Keywords

• Mitokondri
• MOTS-C
• çocuklar
• kronik böbrek hastalığı

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