The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment

Yılmaz Kıroğlu; Mine Cinbiş; Mevlüt Bican; Aziz Polat

TR EN

Metotreksat tedavisine bağlı nörotoksisite gelişen iki olgunun Klinik ve radyolojik incelemesi

Abstract

Metotreksat, akut lenfoblastik lösemi, lenfoma veya osteosarkom gibi neoplastik hastalıklarıntedavisinde kullanılan antimetabolit grubu bir kemoterapötik ajandır. Metotreksatın myelosüpresyon,mukozit, hepatik ve tubüler nekroz ile santral sinir sistemi toksisitesi gibi değişik yan etkileribulunmaktadır. Bu makalede akut lenfoblastik lösemi tanısı alan iki olguda metotreksat kullanımısonucu gelişen santral sinir sistemi nörotoksisitesinin klinik ve radyolojik bulguları ile uzun dönemizlemleri sunulmuştur.

Keywords

Metotreksat, akut lenfoblastik lösemi, nörotoksisite, manyetik rezonans görüntüleme

Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Yılmaz Kıroğlu This is me

Mine Cinbiş This is me

Mevlüt Bican This is me

Aziz Polat This is me

Publication Date

July 1, 2008

Submission Date

July 1, 2008

Acceptance Date

-

Published in Issue

Year 2008 Number: 2

IZ

https://izlik.org/JA25TZ55KP

Cite

RIS / Bibtex

APA

Kıroğlu, Y., Cinbiş, M., Bican, M., & Polat, A. (2008). The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pamukkale Medical Journal, 2, 109-112. https://izlik.org/JA25TZ55KP

AMA

1.Kıroğlu Y, Cinbiş M, Bican M, Polat A. The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pam Med J. 2008;(2):109-112. https://izlik.org/JA25TZ55KP

Chicago

Kıroğlu, Yılmaz, Mine Cinbiş, Mevlüt Bican, and Aziz Polat. 2008. “The Clinical and Radiological Investigation of Two Cases With Neurotoxicity Folowing Methotrexate Treatment”. Pamukkale Medical Journal, nos. 2: 109-12. https://izlik.org/JA25TZ55KP.

EndNote

Kıroğlu Y, Cinbiş M, Bican M, Polat A (July 1, 2008) The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pamukkale Medical Journal 2 109–112.

IEEE

[1]Y. Kıroğlu, M. Cinbiş, M. Bican, and A. Polat, “The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment”, Pam Med J, no. 2, pp. 109–112, July 2008, [Online]. Available: https://izlik.org/JA25TZ55KP

ISNAD

Kıroğlu, Yılmaz - Cinbiş, Mine - Bican, Mevlüt - Polat, Aziz. “The Clinical and Radiological Investigation of Two Cases With Neurotoxicity Folowing Methotrexate Treatment”. Pamukkale Medical Journal. 2 (July 1, 2008): 109-112. https://izlik.org/JA25TZ55KP.

JAMA

1.Kıroğlu Y, Cinbiş M, Bican M, Polat A. The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pam Med J. 2008;:109–112.

MLA

Kıroğlu, Yılmaz, et al. “The Clinical and Radiological Investigation of Two Cases With Neurotoxicity Folowing Methotrexate Treatment”. Pamukkale Medical Journal, no. 2, July 2008, pp. 109-12, https://izlik.org/JA25TZ55KP.

Vancouver

1.Yılmaz Kıroğlu, Mine Cinbiş, Mevlüt Bican, Aziz Polat. The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pam Med J [Internet]. 2008 Jul. 1;(2):109-12. Available from: https://izlik.org/JA25TZ55KP