Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report

Türkan Turgay; Ali Aydeniz; Sacide Pehlivan; Mustafa Pehlivan; Özlem Altındağ; Savaş Gürsoy

TR EN

Romatoid artritte TNF-α gen polimorfizmlerinin promoter bölgesinin anti-TNF tedavisine etkisi: Ön çalışma

Abstract

GİRİŞ ve AMAÇ: Bu çalışmanın amacı romatoid artrit hastalarında tümör nekrozis alfa geni (TNF-α) promotor polimorfizmi ile hastalık aktivitesi, klinik parametreler ve değişik tedavilere yanıt arasında ilişkiyi belirlemektir.YÖNTEM ve GEREÇLER: Çalışmamızda DMARD veya anti-TNF tedavisi alan 65 aktif romatoid artrit hastası ve 70 romatolojik hastalığı olmayan kontrol grubunda -308, -238,-857 içeren TNF-α'nın tek nukleotid polimorfizmi PCR-RFLP yöntemi kullanılarak analiz edildi. Tedaviye klinik yanıt hastalık aktivite skoru, görsel analog ölçek ve sağlık değerlendirme anketi kullanılarak başlangıçta ve 6 aylık tedavi sonrasında değerlendirildi.BULGULAR: Romatoid artrit hastalarında TNF-857 CC genotipinin anlamlı olarak fazla olduğu saptandı. Altı aylık tedavi sonunda grupların VAS; HAQ ve hastalık aktivite skorlarında iyileşme benzer bulundu. Buna rağmen hastalık aktivite skorlarında iyileşme TNF grubundaki hastalarda -308 GG genotipi olanlarda -308 AG genotipi olanlara göre daha iyiydi.TARTIŞMA ve SONUÇ: Romatoid artrit hastalarında TNF-857 CC genotipinin hastalığı yatkınlık sağlayabileceği; aynı zamanda -308 genotinideki polimorfizmin tedaviye yanıtta bir rolü olabilir. Romatoid artrit hastalarında TNF-α polimorfizmi ve hastalığa yatkınlık ve tedaviye yanıtın belirlenmesinde ileri çalışmalara gereksinim vardır.

Keywords

Romatoid artrit, TNF-α, geni, promoter polimorfizmleri

Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report

Abstract

INTRODUCTION: The aim of this study was to explore the association between promotor polymorphisms in tumor necrosis factor α (TNF-α) gene and disease activity, clinical parameters and response to different treatments in rheumatoid arthritis patients.METHODS: We analyzed single nucleotide polymorphisms (-308, -238 and -857) in TNF-α gene in 65 patients with active RA who were treated with DMARD or anti-TNF therapy and in 70 control ones who had no rheumatologic problems. TNF-α genotyping were performed by the PCR-RFLP method. Clinical responses were compared by using disease activity score, VAS and health assessment questionnaire at baseline and after 6 months of treatment. RESULTS: A significant positive association was observed at TNF-857 CC genotype in RA patients (p=0.046). At the six months the mean VAS, HAQ and DAS 28 improvement was not significant among groups. Improvement in DAS score was significantly better in -308 GG genotype than -308 AG genotype in anti-TNF subgroup. DISCUSSION AND CONCLUSION: Our results suggest that TNF-857 CC genotype may be associated with susceptibility to disease and polymorphism in TNF-308 genotype may have an effect in response to therapy. Further studies should be warranted to establish TNF-α polymorphisms and susceptibility and response to treatment inrheumatoid arthritis patients.

Keywords

Rheumatoid arthritis, TNF-α, gene, promoter polymorphisms

References

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Details

Primary Language

English

Subjects

-

Journal Section

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Authors

Türkan Turgay

Ali Aydeniz This is me

Sacide Pehlivan This is me

Mustafa Pehlivan This is me

Özlem Altındağ This is me

Savaş Gürsoy This is me

Publication Date

October 1, 2017

Submission Date

October 1, 2017

Acceptance Date

-

Published in Issue

Year 2017 Volume: 10 Number: 3

IZ

https://izlik.org/JA78JG35BX

APA

Turgay, T., Aydeniz, A., Pehlivan, S., Pehlivan, M., Altındağ, Ö., & Gürsoy, S. (2017). Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report. Pamukkale Medical Journal, 10(3), 216-220. https://izlik.org/JA78JG35BX

AMA

1.Turgay T, Aydeniz A, Pehlivan S, Pehlivan M, Altındağ Ö, Gürsoy S. Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report. Pam Med J. 2017;10(3):216-220. https://izlik.org/JA78JG35BX

Chicago

Turgay, Türkan, Ali Aydeniz, Sacide Pehlivan, Mustafa Pehlivan, Özlem Altındağ, and Savaş Gürsoy. 2017. “Influence of Promoter Region of TNF-α Gene Polymorphisms on Anti-TNF Treatment in Rheumatoid Arthritis: Preliminary Report”. Pamukkale Medical Journal 10 (3): 216-20. https://izlik.org/JA78JG35BX.

EndNote

Turgay T, Aydeniz A, Pehlivan S, Pehlivan M, Altındağ Ö, Gürsoy S (October 1, 2017) Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report. Pamukkale Medical Journal 10 3 216–220.

IEEE

[1]T. Turgay, A. Aydeniz, S. Pehlivan, M. Pehlivan, Ö. Altındağ, and S. Gürsoy, “Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report”, Pam Med J, vol. 10, no. 3, pp. 216–220, Oct. 2017, [Online]. Available: https://izlik.org/JA78JG35BX

ISNAD

Turgay, Türkan - Aydeniz, Ali - Pehlivan, Sacide - Pehlivan, Mustafa - Altındağ, Özlem - Gürsoy, Savaş. “Influence of Promoter Region of TNF-α Gene Polymorphisms on Anti-TNF Treatment in Rheumatoid Arthritis: Preliminary Report”. Pamukkale Medical Journal 10/3 (October 1, 2017): 216-220. https://izlik.org/JA78JG35BX.

JAMA

1.Turgay T, Aydeniz A, Pehlivan S, Pehlivan M, Altındağ Ö, Gürsoy S. Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report. Pam Med J. 2017;10:216–220.

MLA

Turgay, Türkan, et al. “Influence of Promoter Region of TNF-α Gene Polymorphisms on Anti-TNF Treatment in Rheumatoid Arthritis: Preliminary Report”. Pamukkale Medical Journal, vol. 10, no. 3, Oct. 2017, pp. 216-20, https://izlik.org/JA78JG35BX.

Vancouver

1.Türkan Turgay, Ali Aydeniz, Sacide Pehlivan, Mustafa Pehlivan, Özlem Altındağ, Savaş Gürsoy. Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report. Pam Med J [Internet]. 2017 Oct. 1;10(3):216-20. Available from: https://izlik.org/JA78JG35BX

Pamukkale Medical Journal is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC).

Romatoid artritte TNF-α gen polimorfizmlerinin promoter bölgesinin anti-TNF tedavisine etkisi: Ön çalışma

Abstract

Keywords

Influence of promoter region of TNF-α gene polymorphisms on anti-TNF treatment in rheumatoid arthritis: Preliminary report

Abstract

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