IL28B polymorphism predict the response to chronic hepatitis C treatment

Year 2018, , 281 - 285, 28.09.2018

Altay Kandemir , Belkıs Ünsal

https://doi.org/10.31362/patd.428482

Abstract

Purpose: Hepatitis
C is an important medical problem which causes chronic liver disease. 170
million people are believed to be infected throughout the world. While
spontaneous hepatitis C virus (HCV) clearance occurs in almost 30 % of patients
with hepatitis C, it becomes chronic in 70 % which may progress to cirrhosis or
hepatocellular carcinoma (HCC). In recent years, IL28B polymorphism on
chromosome 19q13 has been suggested as the most important predictor among the
host factors for sustained virologic response (SVR). In the present study, we
aimed to evaluate the effect of IL28B gene polymorphism on conventional
treatment response.

Materials
and methods: Totally
95 patients treated with a combination of peginterferon and ribavirin during 48
weeks were included the study. Age, gender, AST and ALT levels, insulin and
fasting glucose levels, BMI, fibrosis levels on liver biopsy and
0-4-12-24-48-72-week HCV RNA values were recorded.

Results: In the study
group of 95 HCV-infected patients, the mean age was 52.4±11 years. SVR was
observed in 54 (%56.8) of
patients at the follow up. Demographical and laboratory variables were similar
in SVR and non-SVR groups. IL28B SNP rs12979860 was positive in CC 26 (47.2 %),
CT 25 (45.4%) and TT 4 (7.2 %) patients with SVR group and in CC 4 (10 %), CT
23 (57.5 %), TT 13 (32.5 %) patients with non-SVR group.

Conclusion: SVR was
achieved more likely in HCV genotype 1 rs12979860, and treatment decision may
be changed based on the degree of liver disorder. In this regard, new studies
involving larger patient population from our country are needed.    

Keywords

Hepatitis C, interleukin-28B, genetic variation

Kronik hepatit C tedavisine yanıtı tahmin etmede IL28B gen polimorfizmi

Abstract

Amaç: Hepatit C, kronik karaciğer hastalığına neden olan
büyük bir sağlık sorunudur. Dünya’da 170 milyon insanın enfekte olduğu
düşünülmektedir. Hepatit C’li hastaların
yaklaşık % 30’unda spontan viral klirens meydana gelirken, % 70’inde hastalık
kronikleşmekte, bir kısmında siroz ve hepatosellüler kanser gelişebilmektedir.
Konak faktörleri içinde kalıcı viral yanıtın en iyi belirleyicisi, son yıllarda
ortaya konan kromozom 19q13 üzerindeki IL28 B polimorfizmidir. Çalışmadaki amacımız bölgemizdeki
hasta populasyonunda IL28B gen polimorfizminin tedaviye yanıta olan etkisini
ortaya koymaktır.

Gereç ve yöntem: Çalışmaya 48 haftalık peginterferon ve
ribavirin tedavisi ve sonrasındaki 24. haftada kontrole gelen 95 hasta alındı.
Hastaların tedavi öncesi yaş, cinsiyet, AST, ALT değerleri, insülin ve açlık
glukozu, karaciğer biyopsisinde fibrozis düzeyleri,- 0-4-12-24-48-72. hafta HCV
RNA değerleri kaydedildi.

Bulgular: Hastaların yaş ortalaması 52,4±11 idi. Çalışma
sonunda hastaların 54’ünde (%56.8) kalıcı viral yanıt gözlendi. Tedaviye yanıta
etki eden demografik ve laboratuvar özellikleri kalıcı viral yanıt ve kalıcı olmayan
viral yanıt gruplarında benzerdi. Kalıcı viral yanıt olan hastalarda IL 28B SNP
rs12979860 polimorfizmine bakıldığında; CC 26 (% 47.2), CT 25 (% 45.4), TT 4 (%
7.2) hastada saptandı. Kalıcı viral yanıt olmayan hastalarda IL 28B SNP
rs12979860 polimorfizmi; CC 4 ( % 10) ,CT 23 (% 57.5), TT 13 (% 32.5) hastada
saptandı.

Sonuç:
HCV genotip 1
rs12979860 CC genotipte kalıcı viral yanıt oranının yüksek olması nedeniyle
karaciğer hastalığının şiddetine dayalı tedavi kararını değiştirebilir. Bu
konuda ülkemizde daha büyük hasta populasyonlarını içeren çalışmalara ihtiyaç
vardır.

Keywords

Hepatit C, interlökin-28B, , gene polimorfizmiene polimorfizmi

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