Onkoloji Hastalarında Kemoterapi öncesi HBsAg, AntiHBs ve izole AntiHBc pozitiflik oranları

Abstract

AAmaç:Onkoloji hastalarında uygulanan kemoterapi HBV reaktivasyonuna neden olabilmektedir. Bu çalışmada amacımız hastanemiz onkoloji polikliniğinde takip edilen ve kemoterapi alması planlanan hastalarda kemoterapi öncesinde HBV enfeksiyonu açısından yapılan tarama sonuçlarını değerlendirmektir.

Yöntem:Bu çalışmada Ocak 2014-Aralık 2018 tarihleri arasında xxxxxxxx Hastanesi Medikal Onkoloji Polikliniği’ne başvuran ve kemoterapi alması planlanan, HBV serolojileri taranmış, 544 hasta değerlendirmeye alındı. Hastaların yaş, onkolojik tanıları, HBV enfeksiyonu açısından HBsAg, AntiHBs ve AntiHBc Ig G sonuçları retrospektif olarak tarandı.

Bulgular:Hastanın tamamından HBsAg istenmiş olduğu belirlenmiş olup, 16’sında (16/544) %2,94 HBsAg pozitifliği görüldü. AntiHBs istenen hasta sayısının 158 olduğu ve bu hastalardan 51’nin pozitif %32,27  (51/158) olduğu, İzole AntiHBcIg G pozitiflik oranının ise 4/50 (%8) olduğu belirlendi. HBsAg pozitif 16 hastanın malignite dağılımlarına bakıldığında en sık akciğer ve gastrointestinal kanser olduğu görüldü.

Sonuç:Kemoterapi planlanan hastalarda reaktivasyon, karaciğer yetmezliği, tedaviye ara verme gibi risk faktörleri de göz önüne alınarak hastaların HBV enfeksiyonu açısından taranması ve immunsüpresif tedavi uygulayan hekimlerin bu konuda farkındalığının arttırılması gerektiğini düşünmekteyiz.

Keywords

• onkoloji,Kemoterapi,HBV

The Positivity Ratios of HBsAg, AntiHBs and isolated anti-HB in patients with canser Prior to Chemotherapy

Abstract

Objective:Chemotherapy in oncology patients may cause HBV reactivation. The aim of this study was to evaluate screening results for HBV infection before chemotherapy in patients who are being followed-up and planned to receive chemotherapy in oncology clinic.

Methods:This study included 544 patients who are admitted to the xxxxxxxx Hospital Medical Oncology Outpatient Clinic between January 2014 and December 2018, planned to receive chemotherapy.  Age, diagnoses, HBsAg, AntiHBs and AntiHbcIg G results were screened retrospectively for HBV infection.

Result:When a total of 544 patients who were planned to receive chemotherapy were analyzed with regard to canser type, lung and gastrointestinal cancers were found to be most common.  It was determined that HBsAg was required in all. HBsAg positivity ratio of our patients was 2,94 % (16/544) , anti-HBs positivity was found as  %32,27  (51/158) , the rate of Isolated AntiHBc Ig G was 4/50 (8%) .

      Result of this study considering the risk factors such as reactivation, hepatic failure, interruption of treatment in patients who are scheduled for chemotherapy, we think that the patients should be screened for HBV infection and the awareness of physicians who apply immunosuppressive treatment study should be increased.

Keywords

• oncology,Chemotherapy,HBV

References

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