Malign and benign tumor frequency in patients with acromegaly

Year 2020, , 415 - 423, 14.05.2020

Nusret Yılmaz , Gökhan Tazegül , Ramazan Sarı , Hasan Altunbaş , Mustafa Balcı

https://doi.org/10.31362/patd.656681

Abstract

Purpose: The aim of this study was to determine the prevalence of benign and malignant tumors in acromegaly patients in a single center.
Materials and Methods: Records of 92 patients with acromegaly were retrospectively reviewed. Main clinical characteristics of the patients and characteristics and frequency of benign and malignant tumors were evaluated.
Results: Median age of patients was 51 (26-83) years, 52 (56.5%) were female and 40 (43.5%) were male. 4.3% (n=4) of the patients had a malignancy. All malignancies were thyroid papillary carcinoma. 76.1% of the patients had at least one benign tumor. Of patients underwent specific imaging modalities, thyroid nodules was present in 76% (n=57) of patients who underwent thyroid ultrasography (n=74), colon polyps was present in 21.4% (n=15) of patients who underwent colonoscopy (n=70), gallbladder polyps were present in 5.5% (n = 4) of patients who underwent abdominal ultrasonography (n=72) and benign breast lesions were found in 11.5% (n=6) of women who underwent breast imaging (n=52).
Conclusion: There is an increased risk of thyroid nodules and thyroid cancer in patients with acromegaly. Therefore, acromegaly patients should be actively monitored for thyroid nodules, and if suspicious findings are detected on ultrasonography, they should be evaluated further.

Keywords

Acromegaly, Tumor, Thyroid cancer

Akromegali hastalarında benign ve malign tümör sıklığı

Abstract

Amaç: Bu çalışmada tek bir merkezde izlenen akromegali hastalarındaki benign ve malign tümör sıklığının belirlenmesi amaçlanmıştır.
Gereç ve Yöntem: Toplam 92 akromegali hastasının kayıtları retrospektif olarak incelendi. Hastaların temel klinik karakteristikleri ile hastalarda mevcut olan benign ve malign tümörlerin özellikleri ve sıklıkları değerlendirildi.
Bulgular: Hastaların medyan yaşları 51 (26-83) yıl , 52’si (%56,5) kadın ve 40’ı (%43,5) erkek idi. Hastaların %4,3’ünde (n=4) malignite mevcuttu. Saptanan malignitelerin tümü tiroid papiller karsinomu idi. Hastaların %76,1’inde en az bir benign tümör vardı. Tiroid ultrasonografisi (USG) yapılan hastaların (n=74) %76’sında (n=57) tiroid nodülü, kolonoskopi yapılan hastaların (n=70) %21,4’ünde (n=15) kolon polipi, abdominal USG yapılan hastaların (n=72) %5,5’inde (n=4) safra kesesi polipi, meme görüntülemesi yapılan kadınların (n=52) %11,5’inde (n=6) benign meme lezyonu mevcuttu.
Sonuç: Sonuç olarak akromegali hastalarında artmış tiroid nodülü ve tiroid kanseri riski mevcuttur. Bu nedenle akromegali hastaları tiroid nodülü yönünden aktif olarak izlenmeli, USG’de şüpheli bulgular saptanması durumunda ince iğne aspirasyon biyopsisi ile değerlendirilmelidir.

Keywords

Akromegali, Tümör, Tiroid kanseri

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