The correlation between depression and anxiety levels and quality of life in essential thrombocytosis and polycythemia vera patients
Abstract
Aim: This study was conducted to assess the correlation between depression and anxiety and quality of life in ET and PV patients.
Methods: The study was conducted in the Hematology Clinic of a training and research hospital in the Aegean region of Turkey between July 2016 and May 2017. A total of 60 patients (30 ET patients, 30 PV patients) were included in the study. Eastern Cooperative Oncology Group (ECOG), Karnofsky scale, EORTC QLQ-C30, and Hospital Anxiety and Depression Scale (HADS) were used to collect the data. The data was analyzed using SPSS 20.0 packaged software. The results were assessed at the confidence interval of 95% and significance level of p<0.05.
Results: The age average of ET and PV patients were 60.3±11.2/ years and 58.7±11.7/ years, respectively. ECOG and Karnofsky performance scores were similiar in two group. There was no significant difference between the groups in terms of EORTC QLQ-C30 overall quality of life and HADS-D scores. HADS-A score mean rank was higher in PV patients (p=0.000) (ET: 22.1 in, PV:38.9). Score mean rank of EORTC QLQ-C30 fatigue, dyspnea and financial difficulty subscales (41.5, 38.2, 38.1) in ET patients and score mean rank of EORTC QLQ-C30 cognitive functioning, pain and diarrhea subscales (43.8, 38.9, 41.1) in PV patients were higher (p=0.000). There was a significant correlation between HADS-A and HADS-D scores and EORTC QLQ-C30 overall quality of life score (p<0.01) in ET patients.
Conclusions: As depression and anxiety levels of ET and PV patients increased, their quality of life impaired.
Keywords
Anxiety, Depression, Quality of Life, Myeloproliferative Disorders
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