Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi

Oğuzhan Aksu; Digdem Aydın

doi:10.31362/patd.709909

EN TR

Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi

Abstract

Tip 2 DM hastalarda KMD değerlerinden bağımsız olarak kırık riskinde artış olduğunu gösteren meta analizler mevcuttur. Diyabette kemik frajilitesindeki artış pentosidin ile ilişkilendirilmiştir. Çalışmamızda postmenopozal Tip 2 DM hastalarda kontrol grubuna göre diyabete bağlı olarak artmış kırık riskini ortaya koymak için WHO FRAX ölçeğini kullanarak hesapladığımız kırık riski yüzdesi ile kemik turnover belirteçleri, sclerostin ve pentosidin düzeylerinin ilişkisini göstermeyi planladık. Çalışmaya 55-65 yaş arası 80 postmenopozal kadın alındı. 50 kişi Tip 2 DM grubuna ve 30 kişi (DM olmayan) kontrol grubuna alındı. Çalışmaya sekonder osteoporoz nedenlerine sahip hastalar alınmadı. Diyabetik ve kontrol grubu arasında kırık riski yüzdeleri ve kemik turnover belirteçleri, pentosidin, sclerostin düzeyleri arasında anlamlı fark saptanmadı. Ayrıca kırık riski yüzdesi, KMD değerleri ile serumda bakılan belirteçler arasında korelasyon saptanmadı. Diyabetik hastalarda osteoporoza bağlı kırık riskini değerlendirmede KMD yetersiz olup, kandaki belirteçlerden faydalanılması ve FRAX a entegre edilebilmesi için yeni çalışmalara ihtiyaç vardır. There are some meta analysis about high fracture risk in type 2 DM group, independent of high BMD values. Fracture risk in DM; related with Pentosidine. In this study we aimed to determine whether there is a relation between bone turnover markers, pentosidin, sclerostin and increased fracture risk, calculated with WHO FRAX algoritm. In totaly, 80 postmenupausal women between ages 55-65 were included to this study. 50 patients with type 2 DM for DM group and 30 patients choosed for control group. Patients who have seconder osteoporosis were excluded. As a result of study there was no significant difference between with diabetics and control group as following parameters: Bone turnover markers, pentosidin and sclerostin levels and fracture risk percentages. Morover, among the markers assesed by fracture risk persentages no significant correlation determined.

Keywords

Osteoporoz, Tip 2 DM de fraktür riski, pentosidin, sclerostin

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Details

Primary Language

Turkish

Subjects

Endocrinology

Journal Section

Research Article

Authors

Oğuzhan Aksu ^*
0000-0003-4666-7129
Türkiye

Digdem Aydın
0000-0002-7981-8045
Türkiye

Publication Date

September 18, 2020

Submission Date

March 27, 2020

Acceptance Date

June 8, 2020

Published in Issue

Year 2020 Volume: 13 Number: 3

DOI

https://doi.org/10.31362/patd.709909

IZ

https://izlik.org/JA38FW65LH

APA

Aksu, O., & Aydın, D. (2020). Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pamukkale Medical Journal, 13(3), 593-604. https://doi.org/10.31362/patd.709909

AMA

1.Aksu O, Aydın D. Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pam Med J. 2020;13(3):593-604. doi:10.31362/patd.709909

Chicago

Aksu, Oğuzhan, and Digdem Aydın. 2020. “Postmenapozal Tip-2 Diyabetes Mellitus’lu Hastalarda Osteoporoza Bağlı Kırık Riskinin Ve Kemik Turnoveri’nin Değerlendirilmesi”. Pamukkale Medical Journal 13 (3): 593-604. https://doi.org/10.31362/patd.709909.

EndNote

Aksu O, Aydın D (September 1, 2020) Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pamukkale Medical Journal 13 3 593–604.

IEEE

[1]O. Aksu and D. Aydın, “Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi”, Pam Med J, vol. 13, no. 3, pp. 593–604, Sept. 2020, doi: 10.31362/patd.709909.

ISNAD

Aksu, Oğuzhan - Aydın, Digdem. “Postmenapozal Tip-2 Diyabetes Mellitus’lu Hastalarda Osteoporoza Bağlı Kırık Riskinin Ve Kemik Turnoveri’nin Değerlendirilmesi”. Pamukkale Medical Journal 13/3 (September 1, 2020): 593-604. https://doi.org/10.31362/patd.709909.

JAMA

1.Aksu O, Aydın D. Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pam Med J. 2020;13:593–604.

MLA

Aksu, Oğuzhan, and Digdem Aydın. “Postmenapozal Tip-2 Diyabetes Mellitus’lu Hastalarda Osteoporoza Bağlı Kırık Riskinin Ve Kemik Turnoveri’nin Değerlendirilmesi”. Pamukkale Medical Journal, vol. 13, no. 3, Sept. 2020, pp. 593-04, doi:10.31362/patd.709909.

Vancouver

1.Oğuzhan Aksu, Digdem Aydın. Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi. Pam Med J. 2020 Sep. 1;13(3):593-604. doi:10.31362/patd.709909

Pamukkale Medical Journal is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC).

Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi

Evaluation of osteoporosis and the risk of secondary fractures in postmenopausal 55- 60 years old patients with type-2 diabetes mellitus

Abstract

Postmenapozal Tip-2 diyabetes mellitus’lu hastalarda osteoporoza bağlı kırık riskinin ve kemik Turnoveri’nin değerlendirilmesi

Abstract

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