Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses

Derya Kılıç; Hakan Yetimalar; Gülcan Sağlam; Mehmet Köseoğlu

doi:10.31362/patd.712419

Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses

Öz

Purpose: Human epididymis protein 4 (HE4) is a novel biomarker for ovarian cancers. The aim of this study is to assess the usefulness and efficacy of HE4, in comparison with CA-125 in the differential diagnosis of malignant and benign gynecological diseases in women with adnexal masses. Materials and Methods: 85 patients diagnosed with adnexial mass who were operated at a tertiary referral center between the years of 2012 and 2013 were included in the study. Demographic data, physical examination, results of the laboratory tests, imaging, and pathology were recorded from all subjects. Blood samples were collected before surgery for the evaluation of HE4 and CA-125 levels. Patients were divided into 4 groups according to their histopathologic diagnosis: benign (n:58), malignant (n:17), borderline (n:5) and metastatic (n:5) and serum CA-125 and HE4 levels were compared considering menopausal status. Results: Using 35 U/mL as the cut-off value, CA-125 had a sensitivity of 82.4%, spesificity of 67.2%, a negative predictive value of 92.9%, and a positive predictive value of %42.4%. For the same sensitivity level, specificity was 87.9%, negative predictive value was 94.4%, and the positive predictive value was 66.7% for HE4. Receiver operator characteristic (ROC) area under the curve was higher in both the premenopausal and postmenopausal group for the HE4 curve. Accordingly, sensitivity at set specificity of 90% was 82.4%, and 70.6% for 95% of specificity and 41.1% for 98%. Same sensitivity values for CA-125 were 47.1%, 35.3% and 23.5%, respectively. Conclusion: According to our study, especially in the premenopausal period, HE4 shows higher sensitivity and specificity values than CA-125.

Anahtar Kelimeler

adnexal mass,ovarian cancer,CA-125,HE4

References

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Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Derya Kılıç ^*
0000-0001-8003-9586
Türkiye

Hakan Yetimalar
Türkiye

Gülcan Sağlam This is me
Türkiye

Mehmet Köseoğlu
Türkiye

Publication Date

May 14, 2020

Submission Date

April 1, 2020

Acceptance Date

April 20, 2020

Published in Issue

Year 2020 Volume: 13 Number: 2

DOI

https://doi.org/10.31362/patd.712419

IZ

https://izlik.org/JA93YE33AS

Cite

RIS / Bibtex

AMA

1.Kılıç D, Yetimalar H, Sağlam G, Köseoğlu M. Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses. Pam Med J. 2020;13(2):403-413. doi:10.31362/patd.712419