Evaluation of metabolic and inflammatory markers in patients undergoing obesity surgery

Abstract

Purpose: Obesity is known to improve chronic inflammatory status. It is known that chronic diseases and inflammation regress with weight loss after bariatric surgery. The aim of this study is to evaluate early metabolic and inflammatory changes after laparoscopic sleeve gastrectomy.

Materials and methods: The demographic features of the patients who were operated for morbid obesity were evaluated before and after the operation, body mass index, waist circumference, blood leukocyte count, CRP, AST, ALT, GGT levels.

Results: Eighty-two patients were included in this study. 21 (25.6%) patients were male and 61 (74.4%) were female. Mean age was 33.7±9.6 (18-64), mean BMI was 42.9±6.1 kg/m² (32.3-59.4), waist circumference was 126.6±17.7 cm (103-153). Although no significant difference was found between preop and postop mean values, leukocyte, ALT, AST and GGT mean values ​​were found to be lower in the early postop postoperative period.

Conclusion: Chronic inflammation caused by obesity is associated with diabetes, insulin resistance and cancer. Bariatric surgery induced weight loss and anatomical changes can play an important role in healing chronic inflammation.

Keywords

• Obesity
• inflammation
• sleeve gastrectomy

Obezite cerrahisi sonrası metabolik ve inflamatuar belirteçlerin değerlendirilmesi

Abstract

Amaç: Obezite kronik inflamasyona neden olmaktadır. Bariatrik cerrahi sonrası kilo kaybı ile kronik hastalıklar ve inflamasyonun gerilediği bilinmektedir.  Bu çalışmanın amacı laparoskopik sleeve gastrektomi sonrası erken dönem metabolik ve inflamatuar değişimlerin değerlendirilmesi amaçlanmıştır.

Gereç ve yöntem: Morbid obezite nedeniyle opere edilen hastaların demografik özellikleri ile birlikte operasyon öncesi ve sonrası vücut kitle indeksi, bel çevresi, kan lökosit sayısı, CRP, AST, ALT, GGT, düzeyleri değerlendirilmiştir.

Bulgular: Çalışmaya dahil edilen 82 morbid obez hastanın 21 (%25,6) erkek, 61 (%74,4) kadındı. Ortalama yaşı 33,7±9,6 (18-64), ortalama BMI 42,9±6,1 kg/m² (32,3-59,4), bel çevresi 126,6±17,7 cm (103-153) idi. Preop ve postop ortalama değerler arasında anlamlı fark saptanmamakla birlikte lökosit, ALT, AST ve GGT ortalama değerlerinin postoperatif erken dönemde daha düşük olduğu saptanmıştır.

Sonuç: Obezitenin sebep olduğu kronik inflamasyon durumu diyabet, insülin direnci ve kanser ile ilişkilidir. Cerrahi olarak indüklenen kilo kaybı ve anatomik değişiklikler kronik inflamasyonda iyileşme için önemli bir rol oynayabilir.

Keywords

• obezite
• inflamasyon
• Sleeve gastrektomi

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