Nötrofil- lenfosit oranı ve trombosit- lenfosit oranlarının çocuklardaki kistik fibroz dışı bronşektazinin akut alevlenmesinde potansiyel biyolojik gösterge olarak değerlendirmesi

Year 2020, , 759 - 766, 18.09.2020

Ayse Ayzıt Kılınç , Gulizar Alishbayli Nursena Kologlu Haluk Çokuğraş

https://doi.org/10.31362/patd.752594

Abstract

Özet

Amaç: Kistik fibroz dışı
bronsektazi (KFDBE) çocuklarda önemli morbiditeye yol açan kronik inflamatuar
akciğer hastalığıdır. KFDBE'de alevlenme akciğer fonksiyonlarının kötüye
gitmesi ile ilişkilidir. Nötrofil- lenfosit oranı (NLO), trombosit- lenfosit
oranı (TLO) ve ortalama trombosit hacmi (OTH) gibi bazı laboratuar
parametrelerinin çesitli kronik inflamatuar hastalıkları için bir gösterge
olduğu öne sürülmüştür. Çalışmamızda, KFDBE’li çocuklardaki akut alevlenmede
NLO, TLO ve OTH ölçümlerinin bir gösterge olarak değerlendirilmesini amaçladık.

Gereç ve yöntem: Çalışmada,
akut alevlenme ve stabil dönemdeki 55 KFDBE' li hastanın ve 79 sağlıklı kontrol
grubunun NLO, TLO ve OTH değerleri analiz edildi.

Bulgular: Çalışma ve kontrol
grubundaki hastaların ortalama yaşları sırasıyla 13,62±3,5 ve 12,72±2,68 yıldı.
Çalışma grubunun %64'ü ve kontrol grubunun %54'ü erkekti. Alevlenme dönemindeki
grupta beyaz küre sayısı, nötrofil oranı ve NLO değerleri sağlıklı kontrol
grubundan anlamlı olarak yüksekti (p<0,05).
İki gruptaki TLO ve OTH değerleri arasında anlamli fark yoktu. Çalışma grubunun
akut alevlenme ve stabil dönemleri arasında, sadece ilk bir saniyede zorlu
ekspiryum hacmi (FEV1) ve c-reaktif protein (CRP) seviyeleri arasında anlamlı
fark vardı (p<0,001).

Sonuç: Her ne kadar KFDBE' li
çocuklardaki NLO değeri sağlıklı kontrol grubundaki çocuklara göre anlamlı
ölçüde yüksek olsa da hastalığın stabil durum ve akut alevlenme periyodu
arasında NLO değeri farklılık göstermedi. TLO ve OTH değerleri, KFDBE'li
çocuklardaki akut alevlenmelerde bir gösterge olarak kullanılamaz.

Keywords

Bronşektazi, kistik fibroz dışı bronşektazi, nötrofil-lenfosit oranı, trombosit-lenfosit oranı, ortalama trombosit hacmi

Supporting Institution

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Project Number

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Thanks

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Evaluation of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers of acute exacerbation in children with non-cystic fibrosis bronchiectasis

Abstract

Purpose: Non- cyctic fibrosis bronchiectasis (non-CFBE) is a chronic inflammatory lung disease which causes significant morbidity in children. Exacerbations in non-CFBE are associated with worsening lung function. Several laboratory parameters such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been suggested to be as an indicator in various chronic inflammatory diseases. We aimed to asses the value of the NLR, PLR and MPV as markers of acute exacerbation in pediatric patients with non-CFBE.
Methods: The NLR, PLR, and MPV values of 55 non-CFBE patients (during exacerbation and stable state periods) and 79 healthy control subjects were analyzed.
Results: The mean ages for the patient and control group were 13.62±3.5 and 12.72±2.68 years, respectively. 64% of patients and 54% of control subjects were male. The white blood cell count, absolute neutrophil count, and NLR values were significantly higher in the exacerbation group than in the healthy control group (p<0.05). MPV and PLR values were not significantly different between the two groups. Only forced expiratory volume in one second (FEV1) and C-reactive protein level were significantly different (p<0.001) between the acute exacerbation and stable state periods in the Purpose: Non- cyctic fibrosis
bronchiectasis (non-CFBE) is a chronic inflammatory lung disease which causes
significant morbidity in children. Exacerbations in non-CFBE are associated
with worsening lung function. Several laboratory parameters such as
neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and
mean platelet volume (MPV) have been suggested to be as an indicator in various
chronic inflammatory diseases. We aimed to asses the value of the NLR, PLR and
MPV as markers of acute exacerbation in pediatric patients with non-CFBE.

Methods: The NLR, PLR, and MPV
values of 55 non-CFBE patients (during exacerbation and stable state periods)
and 79 healthy control subjects were analyzed.

Results: The mean ages for the
patient and control group were 13.62±3.5 and 12.72±2.68 years, respectively.
64% of patients and 54% of control subjects were male. The white blood cell
count, absolute neutrophil count, and NLR values were significantly higher in
the exacerbation group than in the healthy control group (p<0.05). MPV and PLR values were not significantly different
between the two groups. Only forced expiratory volume in one second (FEV1) and
C-reactive protein level were significantly different (p<0.001) between the acute exacerbation and stable state periods
in the patient group. Conclusion:
Despite the NLR value being significantly higher in children with non-CFBE than
in healthy control subjects, it did not differentiate between the steady-state
and acute exacerbations periods of the disease. PLR and MPV values also cannot
be used as markers of acute exacerbation in children with non-CFBE.

Keywords

Bronchiectasis, non-cystic fibrosis bronchiectasis, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, mean platelet volume

Project Number

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