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Metotreksat tedavisine bağlı nörotoksisite gelişen iki olgunun Klinik ve radyolojik incelemesi

Year 2008, Issue: 2, 109 - 112, 01.07.2008

Yılmaz Kıroğlu Mine Cinbiş Mevlüt Bican Aziz Polat

Abstract

Metotreksat, akut lenfoblastik lösemi, lenfoma veya osteosarkom gibi neoplastik hastalıklarıntedavisinde kullanılan antimetabolit grubu bir kemoterapötik ajandır. Metotreksatın myelosüpresyon,mukozit, hepatik ve tubüler nekroz ile santral sinir sistemi toksisitesi gibi değişik yan etkileribulunmaktadır. Bu makalede akut lenfoblastik lösemi tanısı alan iki olguda metotreksat kullanımısonucu gelişen santral sinir sistemi nörotoksisitesinin klinik ve radyolojik bulguları ile uzun dönemizlemleri sunulmuştur.

Keywords

Metotreksat akut lenfoblastik lösemi nörotoksisite manyetik rezonans görüntüleme

The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment

Year 2008, Issue: 2, 109 - 112, 01.07.2008

Yılmaz Kıroğlu Mine Cinbiş Mevlüt Bican Aziz Polat

Abstract

Methotrexate is a chemotherapeutic agent which is a member of antimetabolite group drugs, and usedin neoplastic diseases such as acute lymphoblastic leukemia, lymphoma and osteosarcoma.Methotrexate has various side effects such as myelosuppression, mucositis, hepatic and tubularnecrosis, central nervous system toxicities. In this article, clinical and radiological findings and longtermfollow-up of two cases with central nervous system neurotoxicity following methotrexatetreatment are presented.

Keywords

Methotrexatet acute lymphoblastic leukemia neurotoxicity magnetic resonance imaging

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Details

Other ID JA59MS85TU
Journal Section Research Article
Authors

Yılmaz Kıroğlu This is me

Mine Cinbiş This is me

Mevlüt Bican This is me

Aziz Polat This is me

Publication Date July 1, 2008
Submission Date July 1, 2008
Published in Issue Year 2008 Issue: 2

Cite

APA Kıroğlu, Y., Cinbiş, M., Bican, M., Polat, A. (2008). The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pamukkale Medical Journal(2), 109-112.
AMA Kıroğlu Y, Cinbiş M, Bican M, Polat A. The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pam Med J. July 2008;(2):109-112.
Chicago Kıroğlu, Yılmaz, Mine Cinbiş, Mevlüt Bican, and Aziz Polat. “The Clinical and Radiological Investigation of Two Cases With Neurotoxicity Folowing Methotrexate Treatment”. Pamukkale Medical Journal, no. 2 (July 2008): 109-12.
EndNote Kıroğlu Y, Cinbiş M, Bican M, Polat A (July 1, 2008) The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pamukkale Medical Journal 2 109–112.
IEEE Y. Kıroğlu, M. Cinbiş, M. Bican, and A. Polat, “The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment”, Pam Med J, no. 2, pp. 109–112, July 2008.
ISNAD Kıroğlu, Yılmaz et al. “The Clinical and Radiological Investigation of Two Cases With Neurotoxicity Folowing Methotrexate Treatment”. Pamukkale Medical Journal 2 (July 2008), 109-112.
JAMA Kıroğlu Y, Cinbiş M, Bican M, Polat A. The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pam Med J. 2008;:109–112.
MLA Kıroğlu, Yılmaz et al. “The Clinical and Radiological Investigation of Two Cases With Neurotoxicity Folowing Methotrexate Treatment”. Pamukkale Medical Journal, no. 2, 2008, pp. 109-12.
Vancouver Kıroğlu Y, Cinbiş M, Bican M, Polat A. The clinical and radiological investigation of two cases with Neurotoxicity folowing methotrexate treatment. Pam Med J. 2008(2):109-12.

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