The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience

Nilgün Altuntaş; Diyar Taşçı Çelebi; Mesut Koçak; Nesibe Andıran

Yenidoğan bebeklerde direkt Coombs testi taraması ve pozitifliğinin morbidite üzerine etkisi; tek merkez deneyimi

Year 2015, Issue: 1, 39 - 44, 01.04.2015

Nilgün Altuntaş Diyar Taşçı Çelebi Mesut Koçak Nesibe Andıran

Abstract

AMAÇ: Yenidoğan indirekt hiperbilirubinemi (İHB) etiyolojisinde immün hemolitik anemiler önemli bir yere sahiptir. Direkt Coombs Testi (DAT) immün kaynaklı hemolizi göstermede önemlidir. Eritrosite bağlı antikorlar coombs testi ile saptanır. Yenidoğan tüm bebeklerde rutin tarama yapılması tartışmalı olsa da bazı merkezlerde kord kanında kan grubu ve DAT taraması yapılmaktadır. Çalışmamızda retrospektif olarak hastanemizde doğan bebeklerin DAT sonuçlarını değerlendirmek, pozitiflik nedenlerini saptamak ve pozitifliğin morbidite üzerine etkilerini belirlemek amaçlanmıştır.YÖNTEMLER: Temmuz 2012-Nisan 2013 tarihleri arasında Keçiören Eğitim ve Araştırma Hastanesi Kadın Doğum Ünitesinde doğan tüm bebeklerin ve annelerinin dosyaları ve hastane otomasyon bilgileri geriye dönük olarak incelendi. Bebeklerin kord kan grubu ve DAT sonuçları, izlemde immün hemolitik hastalık geçirip geçirmediği, İHB nedeni ile hastaneye yatırılarak fototerapi alıp almadığı araştırıldı.BULGULAR: DAT toplam 1122 bebeğin %6,6’sında, İHB nedeniyle yatan bebeklerin ise %37,8’inde pozitif saptandı. DAT pozitif olan yenidoğanların İHB nedeniyle hastaneye yatış oranı negatif olanlara göre anlamlı olarak daha yüksek bulundu (p

Keywords

indirekt hiperbilirubinemi, yenidoğan, coombs test, hemolitik anemi

The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience

Year 2015, Issue: 1, 39 - 44, 01.04.2015

Nilgün Altuntaş Diyar Taşçı Çelebi Mesut Koçak Nesibe Andıran

Abstract

OBJECTIVE: Immune mediated hemolysis has an important role in the etiology of indirect hyperbilirubemia (IHB) in newborns. Immune mediated hemolysis can be shown using Direct Coombs Test (DAT). Antibodies bound to erythrocytes are determined by coombs test. DAT and blood group screening in cord blood are routinely performed in some centers, though controversial. In this study, our aim was to investigate the DAT positivity in newborns borned at our hospital and to evaluate the causes of DAT positivity and its effect on morbidity. METHODS: This study was performed at Kecioren Training and Research Hospital between July 2012 and April 2013. The electronic records of all newborns and their mothers were studied. Babies’ cord blood group and DAT results, presence of any immune hemolytic disease and a history of phototherapy due to IHB was investigated. RESULTS: DAT was found positive in 6.6% of 1122 newborns and in 37.6% of newborns with IHB. The rate of hospitalisation due to IHB was significantly high in newborns with DAT positivity (p

Keywords

indirect hyperbilirubinemia, neonate, coombs test, hemolytic anemia

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Details

Other ID	JA92CR56HT
Journal Section	Research Article
Authors	Nilgün Altuntaş This is me Diyar Taşçı Çelebi This is me Mesut Koçak This is me Nesibe Andıran This is me
Publication Date	April 1, 2015
Submission Date	April 1, 2015
Published in Issue	Year 2015 Issue: 1

Cite

APA	Altuntaş, N., Çelebi, D. T., Koçak, M., Andıran, N. (2015). The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience. Pamukkale Medical Journal(1), 39-44.
AMA	Altuntaş N, Çelebi DT, Koçak M, Andıran N. The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience. Pam Med J. April 2015;(1):39-44.
Chicago	Altuntaş, Nilgün, Diyar Taşçı Çelebi, Mesut Koçak, and Nesibe Andıran. “The Screening of Direct Coombs Test in Newborns and the Effect of Its Positivity on Morbidity; A Single Center Experience”. Pamukkale Medical Journal, no. 1 (April 2015): 39-44.
EndNote	Altuntaş N, Çelebi DT, Koçak M, Andıran N (April 1, 2015) The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience. Pamukkale Medical Journal 1 39–44.
IEEE	N. Altuntaş, D. T. Çelebi, M. Koçak, and N. Andıran, “The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience”, Pam Med J, no. 1, pp. 39–44, April 2015.
ISNAD	Altuntaş, Nilgün et al. “The Screening of Direct Coombs Test in Newborns and the Effect of Its Positivity on Morbidity; A Single Center Experience”. Pamukkale Medical Journal 1 (April 2015), 39-44.
JAMA	Altuntaş N, Çelebi DT, Koçak M, Andıran N. The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience. Pam Med J. 2015;:39–44.
MLA	Altuntaş, Nilgün et al. “The Screening of Direct Coombs Test in Newborns and the Effect of Its Positivity on Morbidity; A Single Center Experience”. Pamukkale Medical Journal, no. 1, 2015, pp. 39-44.
Vancouver	Altuntaş N, Çelebi DT, Koçak M, Andıran N. The screening of direct Coombs test in newborns and the effect of its positivity on morbidity; a single center experience. Pam Med J. 2015(1):39-44.