Yeni tanı konulmuş glukoz metabolizma bozukluğu olan hastalarda serum visfatin konsatrasyonun değerlendirilmesi

Year 2019, Volume: 12 Issue: 3, 401 - 406, 30.09.2019

Kamil Gönderen , İrem Bilgetekin Aysun Gönderen , Mehmet Yıldız

https://doi.org/10.31362/patd.540973

Abstract

Amaç: Visfatin, visseral adipoz doku tarafından
salgılanan, insülin-mimetik etkileri olan ve plazma glukoz seviyelerini düşüren
hücre içi bir enzimdir. Yeni tanı konulan glukoz metabolizma bozukluklarında
visfatinin rolü ile ilgili yapılan çalışmalar sınırlıdır. Bu çalışmanın amacı
bozulmuş açlık glukozu ve bozulmuş glukoz toleransı olan hastalarda visfatin
serum konsantrasyonunu değerlendirmektir.
Gereç ve yöntem: Anormal glukoz metabolizması tanısı alan 57 hasta, oral
glukoz tolerans testi (OGTT) sonuçlarına göre bozulmuş açlık glukozu (BAG) (n =
39) ve BAG+ bozulmuş glukoz toleransı (BGT) (n = 18) olarak alt gruplara
ayrıldı. Kontrol grubu, normal glukoz toleransı olan ve herhangi bir metabolik
bozukluğu olmayan 44 sağlıklı bireyden oluşuyordu. Tüm katılımcıların serum
lipidleri, yüksek duyarlı CRP, ürik asit, glikolize hemoglobin (HbA1c) ve serum
visfatin düzeyleri ölçüldü. Bulgular: BAG
grubunun visfatin düzeyi 93.92 ± 12.95, BAG + BGT grubunun 37.79 ± 29.36,
kontrol grubunun 43.96 ± 38.57 idi. Grupların serum visfatin düzeyleri arasında
istatistiksel olarak anlamlı fark vardı (p <0.001). BAG grubunun ortalama
visfatin düzeyi, BAG + BGT ve kontrol gruplarından istatistiksel olarak daha
yüksekti (sırasıyla p <0.001, p <0.001). BAG + BGT grubunun visfatin
düzeyi kontrol grubununkinden düşüktü, ancak aradaki fark istatistiksel olarak
anlamlı değildi (p = 0.785). Visfatin düzeyleri toplam kolesterol, HDL, LDL,
hsCRP, ferritin ve HbA1c düzeyleri ile negatif korelasyon gösterdi, TG, HOMA-ir
ve BMI değerleri ile pozitif korelasyon gösterdi, ancak bu iliĢkiler
istatistiksel olarak anlamlı değildi. Sonuç:
BAG olan hastaların visfatin düzeyleri sağlıklı kontrollerden daha
yüksekti, ancak visfatin seviyeleri HOMA-ir, BMI, TG, HDL, LDL, hsCRP,
ferritin, MPV, HbA1c ve kolesterol düzeyleri arasında anlamlı korelasyon
saptanmadı.

Keywords

Visfatin, Impaired Fasting Glucose

Visfatin concentration in patients with newly-diagnosed glucose metabolism disorders

Abstract

ABSTRACT

Purpose: Visfatin, protein secreted by visceral adipose tissue,
visfatin is an intracellular enzyme that has insulin-mimetic effects and lowers
plasma glucose levels. Data about the role of visfatin in newly diagnosed
glucose metabolism abnormalities are limited. The aim of the work was to assess
serum concentration of visfatin in impaired fasting glucose and impaired
glucose tolerance. Materials and
Methods: 57 patients with diagnosis of abnormal glucose metabolism were
divided into the subgroups according to the oral glucose tolerance test (OGTT)
results as impaired fasting glucose(IFG) (n=39) and IFG+ impaired glucose
tolerance (IGT) (n=18). The control group consisted of 44 healthy controls with
normal glucose tolerance and without any metabolic disorders. Serum lipids,
high sensitive CRP, uric acide, glycated haemoglobin (HbA1c) and serum visfatin
levels were measured in all participants.
Results: The mean visfatin level of IFG group was 93.92±12.95, IFG+IGT
group was 37.79±29.36 and control group was 43.96±38.57. There was
statistically significant difference between serum visfatin levels of the
groups (p<0.001). Mean visfatin level of IFG group was statistically higher
than IFG+IGT and control groups (respectively p<0.001, p<0.001). Mean
visfatin level of IFG+IGT group was lower than the control group however, the
difference was not statistically significant (p=0.785). Visfatin levels were
negatively correlated with total cholesterol, HDL, LDL, hsCRP, ferritin and
HbA1c levels, positively correlated with TG, HOMA-ir and BMI values, however
these relationships were not statistically significant. Conclusion: Visfatin levels of patients with IFG were higher than
healthy controls however, visfatin levels were not correlated with HOMA-ir,
BMI, TG, HDL, LDL, hsCRP, ferritin, MPV, HbA1c and cholesterol levels.

Keywords

Visfatin, Impaired Fasting Glucose

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