Primary central nervous system lymphomas: retrospective analysis of 10 cases.

Year 2020, Volume: 13 Issue: 3, 605 - 611, 18.09.2020

Ayşegül Özdemir Gökhan Canaz , Abdullah Taçyıldız Mustafa Uysal Talat Ovalıoğlu

https://doi.org/10.31362/patd.681161

Abstract

Purpose: Primary central
nervous system (CNS) lymphoma, a rare form of non-Hodgkin's lymphoma (NHL), is
defined as high-grade B cell neoplasm of aggressive extranodal CNS. The
incidence of CNS lymphoma has been increasing in recent years. In general, it
has a poor prognosis. The aim of this study is to evaluate the clinical,
pathological, immunohistochemical and radiological features of patients with
primary CNS lymphoma in the light of literature.

Materials and methods: Between May 2011
and January 2017, 10 patients with pathologic confirmation of primary CNS
lymphoma were retrospectively reviewed.

Results: Of 10 patients with
CNS lymphoma, 7 (70%) were female and 3 (30%) were male. The mean age of all
patients at diagnosis was 59.1±13.98 years. The most common settlements; eight
patients (80%) had basal ganglia and 3 patients (30%) had multiple intracranial
masses. Sterotaxic brain biopsy was performed in 8 patients (80%) and tumor
resection was performed by craniotomy in 2 patients (20%). All of the patients
with non-Hodgkin B cell lymphoma had diffuse large B cell lymphoma in 10
(100%). All cases had diffuse and strong positivity for CD20. None of the
patients had immunodeficiency.

Conclusion: Primary CNS
lymphoma with a poor prognosis is frequently seen over 55 years of age. Diffuse
large B-cell lymphoma is the most common subtype and basal ganglia is the most
common site.

Keywords

Non-Hodgkin lymphoma, large B cell lymphoma, Central nervous system, primary lymphoma

Primer santral sinir sistemi lenfomaları: 10 vakanın retrospektif analizi.

Abstract

Amaç: Non-Hodgkin
lenfoma (NHL)’ nın nadir bir formu olan primer santral sinir sistemi (SSS)
lenfoması, agresif ekstranodal SSS’nin yüksek gradlı B hücre neoplazmı olarak
tanımlanır. SSS lenfoma insidansı son yıllarda giderek artmaktadır. Genel
olarak kötü prognoza sahiptir. Bu çalışmada; primer SSS lenfoması tanısı alan
hastaların klinik, patolojik, immünhistokimyasal ve radyolojik özellikleri
literatür eşliğinde değerlendirmesi amaçlanmıştır.

Gereç ve yöntem: Mayıs 2011 ile Ocak
2017 tarihleri arasında primer SSS lenfoma tanısı patolojik olarak doğrulanmış
10 hasta retrospektif olarak incelendi.

Bulgular: SSS lenfomalı 10
hastanın 7 (%70)’si kadın 3 (%30)’ü erkekti. Tüm hastaların tanı konulduğundaki
ortalama yaşları 59,1±13,98 idi. En sık yerleşim yeri; 8 hastada (%80) bazal
ganglia bölgesi olup, 3 hastanın (%30) çoklu intrakranyal kitleleri vardı. 8
hastada (%80) sterotaksik beyin biyopsisi, 2 hastada (%20) kranyotomi le tümör
rezeksiyonu yapıldı. Tümü non-Hodgkin B hücreli lenfoma olan hastaların 10’u da
(%100) diffüz büyük B hücreli lenfoma idi. Tüm vakalarda CD20 için diffüz ve
kuvvetli pozitiflik görüldü. İmmün yetmezlik hiçbir hastada yoktu.

Sonuç: Kötü prognoza sahip
olan primer SSS lenfoması sıklıkla 55 yaşın üzerinde görülür. Diffüz büyük B-hücreli
lenfoma en sık alt tip olup bazal ganglia bölgesi en sık yerleşim yeridir.

Keywords

Non-Hodgkin lenfoma, santral sinir sistemi, primer lenfoma, büyük B hücreli lenfoma

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