Obezite cerrahisi sonrası metabolik ve inflamatuar belirteçlerin değerlendirilmesi

Year 2020, Volume: 13 Issue: 3, 645 - 649, 18.09.2020

Muhammed Raşid Aykota

https://doi.org/10.31362/patd.715707

Abstract

Amaç: Obezite kronik inflamasyona neden olmaktadır. Bariatrik cerrahi sonrası
kilo kaybı ile kronik hastalıklar ve inflamasyonun gerilediği bilinmektedir.  Bu çalışmanın amacı laparoskopik sleeve
gastrektomi sonrası erken dönem metabolik ve inflamatuar değişimlerin
değerlendirilmesi amaçlanmıştır.

Gereç ve yöntem: Morbid obezite nedeniyle opere edilen hastaların demografik
özellikleri ile birlikte operasyon öncesi ve sonrası vücut kitle indeksi, bel
çevresi, kan lökosit sayısı, CRP, AST, ALT, GGT, düzeyleri değerlendirilmiştir.

Bulgular: Çalışmaya
dahil edilen 82 morbid obez hastanın 21 (%25,6) erkek, 61 (%74,4) kadındı.
Ortalama yaşı 33,7±9,6 (18-64), ortalama BMI 42,9±6,1 kg/m² (32,3-59,4),
bel çevresi 126,6±17,7 cm (103-153) idi. Preop ve postop ortalama değerler
arasında anlamlı fark saptanmamakla birlikte lökosit, ALT, AST ve GGT ortalama
değerlerinin postoperatif erken dönemde daha düşük olduğu saptanmıştır.

Sonuç: Obezitenin sebep olduğu kronik inflamasyon durumu diyabet, insülin
direnci ve kanser ile ilişkilidir. Cerrahi olarak indüklenen kilo kaybı ve
anatomik değişiklikler kronik inflamasyonda iyileşme için önemli bir rol
oynayabilir.

Keywords

obezite, inflamasyon, Sleeve gastrektomi

Thanks

Pamukkale Üniversitesi Tıp Fakültesi Özel Çalışma Modülü öğrencileri Bekir Eren Aksoy, Ahmet Coşkun, Barış Aladağ, Alper Ergin ‘e çalışmaya olan katkılarından dolayı teşekkür ederiz.

Evaluation of metabolic and inflammatory markers in patients undergoing obesity surgery

Abstract

Purpose: Obesity is known to improve chronic
inflammatory status. It is known that chronic diseases and inflammation regress
with weight loss after bariatric surgery. The aim of this study is to evaluate
early metabolic and inflammatory changes after laparoscopic sleeve gastrectomy.

Materials and methods: The demographic
features of the patients who were operated for morbid obesity were evaluated
before and after the operation, body mass index, waist circumference, blood
leukocyte count, CRP, AST, ALT, GGT levels.

Results: Eighty-two patients were included in this
study. 21 (25.6%) patients were male and 61 (74.4%) were female. Mean age was
33.7±9.6 (18-64), mean BMI was 42.9±6.1 kg/m² (32.3-59.4), waist
circumference was 126.6±17.7 cm (103-153). Although no significant difference
was found between preop and postop mean values, leukocyte, ALT, AST and GGT
mean values ​​were found to be lower in the early postop postoperative
period.

Conclusion: Chronic inflammation caused by obesity is
associated with diabetes, insulin resistance and cancer. Bariatric surgery
induced weight loss and anatomical changes can play an important role in
healing chronic inflammation.

Keywords

Obesity, inflammation, sleeve gastrectomy

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