Astımlı çocuklarda leptin, adiponektin ve karnitin düzeylerinin akciğer fonksiyonları, astım şiddeti ve BMI ile ilişkisinin değerlendirilmesi

Year 2021, Volume: 14 Issue: 2, 312 - 321, 01.04.2021

Filiz ALKAN BAYLAN Köksal DEVECİ Utku AYGÜNEŞ Zehra Şule HASKOLOĞLU

https://doi.org/10.31362/patd.791578

Abstract

Amaç: Bu çalışmanın amacı astımlı çocuklarda leptin, adiponektin gibi adipokinlerin ve karnitin gibi mediatörlerin serum düzeylerinin akciğer fonksiyonları, hastalık şiddeti ve BMI ile ilişkisini değerlendirmektir.
Gereç ve yöntem: Çalışma kapsamına akut atak döneminde olmayan 97 bronşial astımlı çocuk hasta ve 40 sağlıklı kontrol bireyi alındı. Tüm astım hastalarına spirometre ile solunum fonksiyon testleri yapıldı. Astımlı çocuk hastalar hava yolu obstruksiyon şiddetine göre semptomlar ve spirometrik parametreler kullanılarak GINA kriterlerine göre hafif intermittan, hafif persistan, orta persistan 3 gruba ayrıldı. Venöz kandan ELİSA yöntemi ile leptin, total karnitin ve adiponektin analizleri yapıldı.
Bulgular: Hasta grubu serum leptin değerleri, kontrol grup serum leptin değerlerinden anlamlı düzeyde yüksek bulundu (p=0.001). Hasta grubu serum total karnitin değerleri kontrol gruuninkinden anlamlı düzeyde düşük bulundu (p=0.001). Orta persistan grup adiponektin ve total karnitin değerleri hafif intermitant gruptan anlamlı düzeyde düşük bulundu (p<0.05). Leptin ve total karnitin değerleri ile eozinofil ve BMI değerleri arasında zayıf negatif korelasyon bulundu. Yaş ile leptin, adiponektin ve total karnitin değerleri arasında orta düzey negatif korelasyon bulundu.

Sonuç: Astımlı çocuklarda leptin düzeylerinin arttığını, adiponektin ve total karnitin düzeylerinin azaldığını, adiponektin ve total karnitin düzeylerindeki azalmamın hastalık şiddeti ile ilişkili olabileceğini düşündürdü.

Keywords

astım, leptin, adiponektin, karnitin

Evaluation of the relationship of leptin, adiponectin and carnitine levels with lung function, asthma severity and BMI in children with asthma

Abstract

Purpose: The aim of this study is to evaluate the relationship between serum levels of leptin, adiponectin and carnitine with lung function, disease severity and BMI (Body Mass Index) in children with asthma.
Materials and methods: 97 Pediatric patients with not in acute attack period bronchial asthma and 40 healthy control subjects were included in the study. Pulmonary function tests done to all asthma patients with a spirometer. Children with asthma were divided into 3 groups according to GINA criteria, mild intermittent, mild persistent, and moderate persistent, with using symptoms and spirometric parameters according to the severity of airway obstruction. Leptin, total carnitine and adiponectin analyzes were performed from venous blood by ELISA method.
Results: Patient group serum leptin values were found to be significantly higher than the control group serum leptin values (p = 0.001). Patient group serum total carnitine values were found to be significantly lower than the control group (p = 0.001). Moderate persistent group adiponectin and total carnitine values were found to be significantly lower than mild intermittent group (p <0.05). A weak negative correlation was found between leptin and total carnitine, eosinophil, BMI values. A weak negative correlation was found between total carnitine and eosinophil, BMI values. A moderate negative correlation was found between age and leptin, adiponectin, total carnitine values.
Conclusions: It suggested that leptin levels increased, adiponectin and total carnitine levels decreased in children with asthma and at the same time the decrease in adiponectin and total carnitine levels may be associated with disease severity.

Keywords

Asthma, leptine, adiponectine, carnitine

References

• Referans 1. Beyther DA, Sutherland ER. Overweight, obesity, and ıncident asthma: a meta-analysis of prospective epidemiologic studies. Am J Respir Crit Care Med 2007;175:661-666.
• Referans 2. VonMutis E, Schwart J, Neas LM, Dockery D, Weiss ST. Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III. Thorax 2001;56:835-838.
• Referans 3. Gold DR, Damoskosh AI, Dockery DW, Berkeycs. Body-mass index as a predictor of incident asthma in a prospective cohort of children. Pediatric Pulmonol 2003;36:514-521.
• Referans 4. Fonseca-Alaniz MH, Takada J, CardosoAlonso-Vale MI, Lima FB. Adipose tissue as an endocrine organ: from theorytopractice. J Pediatr 2007;83:192-203.
• Referans 5. Trayhurn P, Wood IS. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 2004;92:347-355.
• Referans 6. Rondinone CM. Adipocyte-derivedhormones, cytokines and mediators. Endocrine 2006;29:81-90.
• Referans 7. Fontana L, Eagon JC, Trujillo ME, Scherrer PE, Klein S. Visceral fat adipokine secretion is associated with systemic inflammation in obesehumans. Diabetes 2007;56:1010-1013.
• Referans 8. Ali Assad N, Sood A. Leptin, adiponectin and pulmonary diseases. Biochimie 2012;94:2180-21892.
• Referans 9. E.P. Brass. Supplemental carnitine and exercise. American Journal of Clinical Nutrition 2000;72:618-623.
• Referans 10. Kavukçu K, Turkmen M, Salman S, Onvural B, Oktay G, Karaman O, et al. The effects of L-carnitine on respiratory function tests in children undergoing chronic hemodialysis. Türk j. Pediatr 1998;40:79-84.
• Referans 11. From the Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA). 2007. http://www.ginasthma.org.)
• Referans 12. Shore SA. Obesity and asthma: lessons from animal models. J Appl Physiol 2007;102:516-528.
• Referans 13. Guler N, Kirerleri E, Ones U, Tamay Z, Salmayenli N, Darendeliler F. Leptin: does it haveany role in childhood asthma? J Allergy Clin Immunol 2004;114:254-259.
• Referans 14. Gurkan F, Atamer Y, Ece A, Kocyigit Y, Tuzun H, Mete N. Serum leptin levels in asthmatic children treated with an inhaled cortico¬steroid. Ann Allergy Asthma Immunol 2004;93:277-280.
• Referans 15. Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biologicalaction of leptin as an angiogenicfactor. Science 1998;281:1683-686.
• Referans 16. Torday JS, Sun H, Wang L, Torres E, Sunday ME, Rubin LP. Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation. Am J Physiol Lung Cell Mol Physiol 2002;282:405-410.
• Referans 17. Yuksel H, Sogut A, Yilmaz O, Onur E, Dinc G. Role of adipokines and hormones of obesity in childhood asthma. Allergy Asthma Immunol Res. 2012;4:98-103.
• Referans 18. Blum WF, Englaro P, Hanitsch S,et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997;82:2904-2910.
• Referans 19. Mai XM, Böttcher MF, Leijon I. Leptin and asthma in overweight children at 12 years of age. Pediatr Allergy Immunol 2004;15:523-530.
• Referans 20. Sin DD, Man SFP. Impaired lung function and serum leptin in men and women with normal body weight: a population based study. Thorax 2003;58:695-698.
• Referans 21. Güler N, Kirerleri E, Ones Ü, et al. Leptin: Does it haveany role in childhood asthma? J Allergy Clin Immunol 2004;114:254-259.
• Referans 22. Meier U, Gressner AM. Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin. Clin Chem 2004;50:1511-1525.
• Referans 23. Faraj M, Havel PJ, Phélis S, Blank D, Sniderman AD, Cianflone K. Plasma acylation-stimulating protein, adiponectin, leptin, and ghrelin before and after weight loss induced by gastric bypass sur¬gery in morbidly obese subjects. J Clin Endocrinol Metab 2003;88:1594-1602.
• Referans 24. Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem 2005;280:18341-18347.
• Referans 25. Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy ClinImmunol 2006;118:389-395.
• Referans 26. Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffers MW, Smith LJ, Jacobs DR. Association between asthma and serum adiponectin concentration in women. Thorax 2008;63:877–882.
• Referans 27. Holguin F, Rojas M, Brown L, Fitzpatrick M. J Asthma. 2011;48: 217–223.
• Referans 28. Huangand S. L. , Pan W. H. “Dietary fats and asthma in teenagers: analyses of the first nutrition and health survey in Taiwan (NAHSIT),” Clinicaland Experimental Allergy 2001;31:1875–1880.
• Referans 29. Asilsoy S, Bekem O, Karaman O, Uzuner N, and Kavukcu S. Serum total and free carnitine levels in children with asthma, World Journal of Pediatrics 2009;5:60–62.
• Referans 30. Ergür A. T, Tanzer F, and Çetinkaya Ö. “Serum free carnitin elevels in children with recurrent pulmonary infections,” Acta Paediatrica Japonica 1997;39:406–408.
• Referans 31. Hallstrandand T. S, Henderson Jr WR. An update on the role of leukotrienes in asthma. Current Opinion in Allergy and Clinical Immunology 2010;10:60–66.
• Referans 32. Borghi-Silva A, Baldissera V, Sampaio L.M.M et al. L-carnitine as an ergogenicaid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs. Brazilian Journal of Medical and BiologicalResearch 2006;39:465–474.
• Referans 33. Al-Biltagi M, Isa M, Bediwy A.S, Helaly N, and El Lebedy D. D. L-Carnitine Improves the Asthma Control in Children with Moderate Persistent Asthma. Hindawi Publishing Corporation Journal of Allergy 2012; doi:10.1155/2012/509730.