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Prognostic factors in vulvar cancer patients: a single center experience

Year 2021, Volume: 14 Issue: 4, 900 - 907, 01.10.2021
https://doi.org/10.31362/patd.978808

Abstract

Purpose: Many prognostic factors have been investigated in vulvar cancer patients. In our study, we aimed to
compare clinical and pathological prognostic factors and investigate the factors that affect the recurrence and
survival in patients with recurrent and non-recurrent squamous cell vulvar cancer.
Materials and methods: This retrospective study was conducted in Tepecik Research Hospital, Izmir, Turkey
between 1999-2020. The descriptive features, prognostic factors and survival in recurrent patients were
evaluated.
Results: Tumor invasion depth, surgical margin positivity, lymphovascular space invasion (LVSI), are
statistically significant for recurrence (p=0.03, p=0.00, p=0.04). Variables such as age, tumor size, surgical
margin distance (mm), tumor localization, presence of metastatic lymph node, operation type (surgery with
lymph node dissection) and adjuvant therapy were not found to be statistically significant in terms of recurrent
patients with vulvar cancer. There was correlation between recurrence, LVSI, surgical margin positivity, stage
and survival in Kaplan Meier survival analysis.
Conclusion: As in other studies, many prognostic factors like tumor invasion depth, surgical margin positivity,
LVSI are risk factors for recurrence in our study. Stage, LVSI, recurrence, surgical margin positivity were
significant factors for survival as well.

References

  • 1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7–34.
  • 2. de Hullu JA, van der Zee AG. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006;60(1):38–58.
  • 3. Zweizig S, Korets S, Cain J. Key concepts in management of vulvar cancer. Best Practice Res Clin Obstet Gynaecol 2014;28:959-966.
  • 4. Tan A, Bieber AK, Stein JA, Pomeranz MK. Diagnosis and management of vulvar cancer: A review. J Am Acad Dermatol. 2019;81(6):1387-1396.
  • 5. Baiocchi G, Silva Cestari FM, Rocha RM et al. Prognostic value of the number and laterality of metastatic inguinal lymph nodes in vulvar cancer: revisiting the FIGO staging system. Eur J Surg Oncol 2013;39(7):780–5.
  • 6. Te Grootenhuis NC, van der Zee AG, van Doorn HC et al. Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen International Study on Sentinel nodes in Vulvar cancer (GROINSSV). Gynecol Oncol 2016;140(1):8-14.
  • 7. Heaps JM, Fu YS, Montz FJ, Hacker NF, Berek JS. Surgical-Pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynaecologic Oncol 1990;38:309-14.
  • 8. Iversen T, Aalders JG, Christensen A. Squamous cell carcinoma of the vulva: a review of 424 patients, 1956–1974. Gynecol Oncol1980; 9:271–279.
  • 9. Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol 2012; 83(1):71-83.
  • 10. Viswanathan AN, Pinto AP, Schultz D, Berkowitz R, Crum CP. Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma. Gynecol Oncol 2013;130(3):545-9.
  • 11. Woelber L, Mahner S, Voelker K et al. Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res.2009;29: 545-52.
  • 12. Zach D, Avall-Lundqvist, Falconer H, Hellman K, Johansson H, Flöter Radestad A. Patterns of Recurrence and Survival in Vulvar Cancer: A Nationwide population based study. 2021;161(3):748-754.
  • 13. Perez CA, Grigsby PW, Chao C et al. Irradiation in carcinoma of the vulva: factors affecting outcome. Int J Radiat Oncol Biol Phys. 1998: 42:335–344.
  • 14. Imoto S, Inamine M, Kudaka W et al. Prognostic Factors in patients with vulvar cancer treated with primary surgery: a single-center experience. 2016;5:125.
  • 15. Woelber L, Mahner S, Voelker K et al. Clinicopathological Prognostic Factors and Patterns of Recurrence in Vulvar Cancer. Anticancer Research 2009;29:545-552.
  • 16. Stankevica J, Macuks R, Baidekalna I, Donina S. Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence. Asian Pacific J Cancer Prev, 2012;13(10):5237-5240.

Vulvar Kanserli Hastalarda Prognostik Faktörler: Tek Merkez Deneyimi

Year 2021, Volume: 14 Issue: 4, 900 - 907, 01.10.2021
https://doi.org/10.31362/patd.978808

Abstract

Amaç: Vulvar kanserli hastalarda birçok prognostik faktör araştırılmıştır. Çalışmamızda nüks ve nüks olmayan skuamöz hücreli vulvar kanserli hastalarda klinik ve patolojik prognostik faktörleri karşılaştırmayı, nüks ve sağkalımı etkileyen faktörleri araştırmayı amaçladık.
Gereç-Yöntem: Bu prospektif çalışma 1999-2020 yılları arasında İzmir, Tepecik Araştırma Hastanesi’nde yapıldı. Tekrarlayan hastalarda tanımlayıcı özellikler, prognostik faktörler ve sağkalım değerlendirildi.
Bulgular: Tümör invazyon derinliği, cerrahi sınır pozitifliği, lenfovasküler boşluk invazyonu (LVSI) nüks açısından istatiksel olarak anlamlıdır(p=0,03, p=0,00, p=0,04). Yaş, tümör boyutu, cerrahi sınır mesafesi (mm), tümör lokalizasyonu, metastatik lenf nodu varlığı, operasyon tipi (lenf nodu diseksiyonlu cerrahi) ve adjuvan tedavi gibi değişkenler nüks vulvar kanseri hastaları açısından istatiksel olarak anlamlı bulunmadı. Kaplan Meier sağkalım analizinde nüks, lenfovasküler boşluk invazyonu, cerrahi sınır pozitifliği, evre ve sağkalım arasında korelasyon vardı.
Sonuç: Diğer çalışmalarda olduğu gibi bizim çalışmamızda da tümör invazyon derinliği,cerrahi sınır pozitifliği, lenfovasküler boşluk invazyonu gibi birçok prognostik faktör nüks için risk faktörüdür. Evre, lenfovasküler boşluk invazyonu, nüks, cerrahi sınır pozitifliği de sağkalım için önemli faktörlerdendir.

References

  • 1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin 2019; 69: 7–34.
  • 2. de Hullu JA, van der Zee AG. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006;60(1):38–58.
  • 3. Zweizig S, Korets S, Cain J. Key concepts in management of vulvar cancer. Best Practice Res Clin Obstet Gynaecol 2014;28:959-966.
  • 4. Tan A, Bieber AK, Stein JA, Pomeranz MK. Diagnosis and management of vulvar cancer: A review. J Am Acad Dermatol. 2019;81(6):1387-1396.
  • 5. Baiocchi G, Silva Cestari FM, Rocha RM et al. Prognostic value of the number and laterality of metastatic inguinal lymph nodes in vulvar cancer: revisiting the FIGO staging system. Eur J Surg Oncol 2013;39(7):780–5.
  • 6. Te Grootenhuis NC, van der Zee AG, van Doorn HC et al. Sentinel nodes in vulvar cancer: long-term follow-up of the GROningen International Study on Sentinel nodes in Vulvar cancer (GROINSSV). Gynecol Oncol 2016;140(1):8-14.
  • 7. Heaps JM, Fu YS, Montz FJ, Hacker NF, Berek JS. Surgical-Pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynaecologic Oncol 1990;38:309-14.
  • 8. Iversen T, Aalders JG, Christensen A. Squamous cell carcinoma of the vulva: a review of 424 patients, 1956–1974. Gynecol Oncol1980; 9:271–279.
  • 9. Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol 2012; 83(1):71-83.
  • 10. Viswanathan AN, Pinto AP, Schultz D, Berkowitz R, Crum CP. Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma. Gynecol Oncol 2013;130(3):545-9.
  • 11. Woelber L, Mahner S, Voelker K et al. Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res.2009;29: 545-52.
  • 12. Zach D, Avall-Lundqvist, Falconer H, Hellman K, Johansson H, Flöter Radestad A. Patterns of Recurrence and Survival in Vulvar Cancer: A Nationwide population based study. 2021;161(3):748-754.
  • 13. Perez CA, Grigsby PW, Chao C et al. Irradiation in carcinoma of the vulva: factors affecting outcome. Int J Radiat Oncol Biol Phys. 1998: 42:335–344.
  • 14. Imoto S, Inamine M, Kudaka W et al. Prognostic Factors in patients with vulvar cancer treated with primary surgery: a single-center experience. 2016;5:125.
  • 15. Woelber L, Mahner S, Voelker K et al. Clinicopathological Prognostic Factors and Patterns of Recurrence in Vulvar Cancer. Anticancer Research 2009;29:545-552.
  • 16. Stankevica J, Macuks R, Baidekalna I, Donina S. Midline Involvement as a Risk Factor for Vulvar Cancer Recurrence. Asian Pacific J Cancer Prev, 2012;13(10):5237-5240.
There are 16 citations in total.

Details

Primary Language English
Subjects Obstetrics and Gynaecology
Journal Section Research Article
Authors

Gülşah Selvi Demirtaş 0000-0002-1634-8365

Fatih Dinçer 0000-0003-0796-6257

Gökşen Görgülü 0000-0003-2837-8497

Muzaffer Sancı 0000-0001-6209-0003

Sevil Sayhan 0000-0003-4783-5550

Publication Date October 1, 2021
Submission Date August 4, 2021
Acceptance Date September 2, 2021
Published in Issue Year 2021 Volume: 14 Issue: 4

Cite

APA Selvi Demirtaş, G., Dinçer, F., Görgülü, G., Sancı, M., et al. (2021). Prognostic factors in vulvar cancer patients: a single center experience. Pamukkale Medical Journal, 14(4), 900-907. https://doi.org/10.31362/patd.978808
AMA Selvi Demirtaş G, Dinçer F, Görgülü G, Sancı M, Sayhan S. Prognostic factors in vulvar cancer patients: a single center experience. Pam Med J. October 2021;14(4):900-907. doi:10.31362/patd.978808
Chicago Selvi Demirtaş, Gülşah, Fatih Dinçer, Gökşen Görgülü, Muzaffer Sancı, and Sevil Sayhan. “Prognostic Factors in Vulvar Cancer Patients: A Single Center Experience”. Pamukkale Medical Journal 14, no. 4 (October 2021): 900-907. https://doi.org/10.31362/patd.978808.
EndNote Selvi Demirtaş G, Dinçer F, Görgülü G, Sancı M, Sayhan S (October 1, 2021) Prognostic factors in vulvar cancer patients: a single center experience. Pamukkale Medical Journal 14 4 900–907.
IEEE G. Selvi Demirtaş, F. Dinçer, G. Görgülü, M. Sancı, and S. Sayhan, “Prognostic factors in vulvar cancer patients: a single center experience”, Pam Med J, vol. 14, no. 4, pp. 900–907, 2021, doi: 10.31362/patd.978808.
ISNAD Selvi Demirtaş, Gülşah et al. “Prognostic Factors in Vulvar Cancer Patients: A Single Center Experience”. Pamukkale Medical Journal 14/4 (October 2021), 900-907. https://doi.org/10.31362/patd.978808.
JAMA Selvi Demirtaş G, Dinçer F, Görgülü G, Sancı M, Sayhan S. Prognostic factors in vulvar cancer patients: a single center experience. Pam Med J. 2021;14:900–907.
MLA Selvi Demirtaş, Gülşah et al. “Prognostic Factors in Vulvar Cancer Patients: A Single Center Experience”. Pamukkale Medical Journal, vol. 14, no. 4, 2021, pp. 900-7, doi:10.31362/patd.978808.
Vancouver Selvi Demirtaş G, Dinçer F, Görgülü G, Sancı M, Sayhan S. Prognostic factors in vulvar cancer patients: a single center experience. Pam Med J. 2021;14(4):900-7.

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