Analytical investigation of demographic, laboratory, and clinical characteristics of patients with microbial keratitis

Year 2024, Volume: 17 Issue: 1, 27 - 31, 01.01.2024

Fatma Sümer , İlkay Bahçeci , Süleyman Karaman , Feyzahan Uzun

https://doi.org/10.31362/patd.1311349

Abstract

Purpose: In this study, we investigated epidemiological properties, clinical findings, risk factors, direct microscopy, and culture results in patients diagnosed with microbial keratitis.
Materials and methods: We examined the hospital records of patients with microbial keratitis between March 2016 and March 2021, retrospectively. Also, clinical findings, risk factors, microbiological results, empirical treatment and, treatment responses were evaluated.
Results: 42 eyes of 42 patients whose mean age was 57.8 (range 18-70 years) were included in the study. Grampositive and gram-negative bacteria were found on stained microscopic examination in 12 patients (28.5%). In total, microbial growth was detected in the culture of 7 patients (16.6%), while growth was not detected in 35
patients (83.4%). No etiological factor was detected in 27 patients (64.4%). The complaints at admission were pain in 24 patients (57.6%), redness in 12 patients (28.8%), and both redness and pain in 6 patients (14.1%). While the visual acuity of 18 cases was preserved after the treatment, 24 cases (88.8%) achieved 1 or more line with the treatment. While the mean visual acuity was 0.79±1.1 (0-3.1) logMAR before treatment, it increased to 0.69±1.1 (0-3.1) logMAR after treatment (p=0.006).
Conclusion: The keratitis is a common cause of unilateral blindness. Early diagnosis and treatment of keratitis is a significant role in the prognosis. The success of the therapy can be provided by starting empirical antimicrobial therapy by taking into consideration of the regional risk factors and common pathogens.

Keywords

Etiology, keratitis, treatment

Mikrobiyal keratitli hastaların demografik, laboratuvar ve klinik özelliklerinin analitik olarak incelenmesi

Abstract

Amaç: Bu çalışmada mikrobiyal keratit tanısı alan hastalarda epidemiyolojik özellikler, klinik bulgular, risk faktörleri, direkt mikroskopi ve kültür sonuçlarını inceledik.
Gereç ve yöntem: Mart 2016-Mart 2021 tarihleri arasında mikrobiyal keratit tanısı alan hastaların hastane kayıtları retrospektif olarak incelendi. Ayrıca klinik bulgular, risk faktörleri, mikrobiyolojik sonuçlar, ampirik tedavi ve tedaviye yanıt değerlendirildi.
Bulgular: Yaş ortalaması 57,8 (dağılım 18-70) olan 42 hastanın 42 gözü çalışmaya dahil edildi. Boyalı mikroskopik incelemede 12 hastada (%28,5) gram-pozitif ve gram-negatif bakteriler saptandı. Toplamda 7 hastada kültürde üreme saptandı (%16,6), 35 hastada (%83,4) büyüme saptanmazken, 27 hastada (%64,4) etyolojik özellik
saptanmadı, 24 hastada (%57,6) başvuru yakınmaları ağrı, 12 hastada (%28,8) kızarıklık şeklindeydi %) ve 6 hastada (%14,1) kızarıklık ve ağrı şikayetleri vardı. 18 olgunun tedavi sonrası görme düzeyleri korunurken, olguların 24'ünde (%88,8) tedavi ile 1 sıra ve üzeri görme artışı sağlandı. Tedavi öncesi ortalama görme keskinliği 0,79±1,1 (0-3,1) logMAR iken tedavi sonrası 0,69±1,1 (0-3,1) logMAR'a yükseldi (p=0,006).
Sonuç: Keratit, tek taraflı körlüğün yaygın bir nedenidir. Keratitte erken tanı ve tedavi prognoz üzerinde önemli rol oynar. Bölgesel risk faktörleri ve sık görülen patojenler dikkate alınarak ampirik antimikrobiyal tedaviye başlanması tedavinin başarısı sağlayabilir.

Keywords

Etiyoloji, keratit, tedavi

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