Case Report
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When the pleural fluid appears in an unexpected color: a bilothorax case

Year 2025, Volume: 18 Issue: 1, 20 - 20
https://doi.org/10.31362/patd.1487005

Abstract

Bilothorax, or cholethorax, is a rare cause of exudative pleural effusion characterized by the presence of bile in the pleural space. Recognizing this condition is essential to prevent severe complications such as empyema and acute respiratory distress syndrome. This report presents a 70-year-old male patient who developed right-sided bilothorax following multiple biliary tract interventions. The patient presented with symptoms of jaundice, fever, and abdominal pain. Clinical and radiological evaluations revealed right-sided pleural effusion, and thoracentesis yielded dark yellow-green fluid. The diagnosis of bilothorax was confirmed by a pleural fluid/serum total bilirubin ratio >1.0. Early intervention was performed using a cystofix to drain the pleural fluid. However, despite all interventions, the sepsis condition could not be controlled, and the patient unfortunately passed away. Bilothorax is generally associated with hepatobiliary procedures and is mostly observed on the right side due to anatomical proximity. Diagnosis requires a high index of suspicion, especially in patients with relevant clinical histories and characteristic pleural fluid appearance. Rapid thoracentesis and pleural fluid analysis are crucial for diagnosis. Treatment typically involves pleural drainage and early administration of broad-spectrum antibiotics. In conclusion, bilothorax is a life-threatening condition requiring urgent diagnosis and intervention. This case highlights the importance of recognizing this rare condition and the necessity for early aggressive management in patients with a history of hepatobiliary procedures.

References

  • 1. Addas R, Alsabban A, Fallatah A, Binaqeel A, Bafageeh S, Bawazir A. Bilothorax a rare incidence in thoracic surgery: case report and literature review. Open J Thorac Surg 2021;11:76-82. https://doi.org/10.4236/ojts.2021.113010 2. Ravikumar DB, Sivasubramanian BP, Dominic Savio FV, Gunendran T, Shekar SP. A green surprise: bilateral bilious pleural effusion secondary to esophageal rupture—a case report. Journal of Investigative Medicine High Impact Case Reports 2024;12. https://doi.org/10.1177/23247096241231634
  • 3. Saraya T, Light RW, Sakuma S, et al. A new diagnostic approach for bilious pleural effusion. Respiratory Investigation 2016;54:364-368. https://doi.org/10.1016/j.resinv.2016.03.009
  • 4. Çoşğun İ, Kıter G, Karabulut N, Türk F, Altun M, Evyapan F. A rare cause of pleural effusion: biliopleural fistula. Solunum 2013;15:194-197. https://doi.org/10.5152/solunum.2013.039
  • 5. Reddy VD, Al Khateeb A, Hussain M, Patel V, et al. Case Report: kryptonite—A rare case of left-sided bilothorax in a sickle cell patient". Case Rep Pulmonol 2019;2019:8658343. https://doi.org/10.1155/2019/8658343
  • 6. Temitope O, Nathan S. Bilothorax: a rare complication of percutaneous transhepatic biliary drainage in a patient with primary sclerosing cholangitis. ACG Case Reports Journal 2024;11:p e01326. https://doi.org/10.14309/crj.0000000000001326
  • 7. Shah K, Ravikumar N, Uddin QK, McGee W, Farmer MJS. Bilateral bilothorax: an unusual cause of bilateral exudative pleural effusion. Cureus 2019;11:e5185. https://doi.org/10.7759/cureus.5185
  • 8. Briones Gómez A, Sánchez Samblancat M, Bekki A. A rare presentation of bilothorax. Archivos de Bronconeumología 2023;59:447-448. https://doi.org/10.1016/j.arbres.2023.03.023
  • 9. Basu S, Bhadani S, Shukla VK. A dangerous pleural effusion. Ann R Coll Surg Engl. 2010;92:53-54. https://doi.org/10.1308/147870810X12699662980637
  • 10. Shen TC, Chen CH, Lai HC, et al. Risk of empyema in patients with chronic liver disease and cirrhosis: a nationwide, population-based cohort study. Liver Int 2017;37:862-870. https://doi.org/10.1111/liv.13330
  • 11. Arvaniti V, D'Amico G, Fede G, et al. Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology 2010;139:1246-1256.e5. https://doi.org/10.1053/j.gastro.2010.06.019
  • 12. Cooper AZ, Gupta A, Odom SR. Conservative management of a bilothorax resulting from blunt hepatic trauma. Ann Thorac Surg 2012;93:2043-2044. https://doi.org/10.1016/j.athoracsur.2011.11.024
  • 13. Austin A, Fox N, Huggins JT, Chopra, A. The green pleural effusion: a comprehensive review of the bilothorax with case series. The Official Journal of the International Society of Pleural Diseases. Pleura 2017;4:21-31. https://doi.org/10.1016/j.amjms.2017.03.034

Plevra sıvısının beklenmedik renkte görünmesi: bilotoraks olgusu

Year 2025, Volume: 18 Issue: 1, 20 - 20
https://doi.org/10.31362/patd.1487005

Abstract

Bilotoraks, plevral boşlukta safra varlığı ile karakterize, eksüdatif plevral efüzyonun nadir bir nedenidir. Bu durumun tanınması ampiyem ve akut solunum sıkıntısı sendromu gibi ciddi komplikasyonları önlemek için önemlidir. Bu raporda, birçok safra yolu müdahalesi sonrasında sağ taraflı bilotoraks gelişen 70 yaşındaki bir erkek hasta sunulmaktadır. Hasta sarılık, ateş ve karın ağrısı şikayetleri ile başvurdu. Klinik ve radyolojik değerlendirme ile sağ taraflı plevral efüzyon görüldü ve torasentez ile koyu sarı-yeşil sıvı elde edildi plevral mayii/serum total bilirubin oranının >1,0 olması ile bilotoraks tanısı konuldu. Erken müdehale ie sistofix ile plevral mayi drenajı sağlandı. Ancak tüm müdehalelere rağmen sepsis tablosunun önüne geçilemeyerek hastamız kaybedildi. Bilotoraks, genellikle hepatobiliyer prosedürlerle ilişkilidir ve anatomik yakınlık nedeniyle çoğunlukla sağ tarafta görülür. Tanı, özellikle ilgili klinik öykülere ve karakteristik plevral sıvı görünümüne sahip hastalarda yüksek şüphe gerektirir. Tanı için hızlı torasentez ve plevral sıvı analizi kritik öneme sahiptir. Tedavi genellikle plevral drenaj ve geniş spektrumlu antibiyotiklerin erken uygulanmasını içerir. Sonuç olarak Bilotoraks, acil tanı ve müdahale gerektiren hayatı tehdit eden bir durumdur. Bu olgu, ilgili hepatobiliyer öyküye sahip hastalarda bu nadir durumu tanımanın ve erken agresif yönetimin önemini vurgulamaktadır.

References

  • 1. Addas R, Alsabban A, Fallatah A, Binaqeel A, Bafageeh S, Bawazir A. Bilothorax a rare incidence in thoracic surgery: case report and literature review. Open J Thorac Surg 2021;11:76-82. https://doi.org/10.4236/ojts.2021.113010 2. Ravikumar DB, Sivasubramanian BP, Dominic Savio FV, Gunendran T, Shekar SP. A green surprise: bilateral bilious pleural effusion secondary to esophageal rupture—a case report. Journal of Investigative Medicine High Impact Case Reports 2024;12. https://doi.org/10.1177/23247096241231634
  • 3. Saraya T, Light RW, Sakuma S, et al. A new diagnostic approach for bilious pleural effusion. Respiratory Investigation 2016;54:364-368. https://doi.org/10.1016/j.resinv.2016.03.009
  • 4. Çoşğun İ, Kıter G, Karabulut N, Türk F, Altun M, Evyapan F. A rare cause of pleural effusion: biliopleural fistula. Solunum 2013;15:194-197. https://doi.org/10.5152/solunum.2013.039
  • 5. Reddy VD, Al Khateeb A, Hussain M, Patel V, et al. Case Report: kryptonite—A rare case of left-sided bilothorax in a sickle cell patient". Case Rep Pulmonol 2019;2019:8658343. https://doi.org/10.1155/2019/8658343
  • 6. Temitope O, Nathan S. Bilothorax: a rare complication of percutaneous transhepatic biliary drainage in a patient with primary sclerosing cholangitis. ACG Case Reports Journal 2024;11:p e01326. https://doi.org/10.14309/crj.0000000000001326
  • 7. Shah K, Ravikumar N, Uddin QK, McGee W, Farmer MJS. Bilateral bilothorax: an unusual cause of bilateral exudative pleural effusion. Cureus 2019;11:e5185. https://doi.org/10.7759/cureus.5185
  • 8. Briones Gómez A, Sánchez Samblancat M, Bekki A. A rare presentation of bilothorax. Archivos de Bronconeumología 2023;59:447-448. https://doi.org/10.1016/j.arbres.2023.03.023
  • 9. Basu S, Bhadani S, Shukla VK. A dangerous pleural effusion. Ann R Coll Surg Engl. 2010;92:53-54. https://doi.org/10.1308/147870810X12699662980637
  • 10. Shen TC, Chen CH, Lai HC, et al. Risk of empyema in patients with chronic liver disease and cirrhosis: a nationwide, population-based cohort study. Liver Int 2017;37:862-870. https://doi.org/10.1111/liv.13330
  • 11. Arvaniti V, D'Amico G, Fede G, et al. Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology 2010;139:1246-1256.e5. https://doi.org/10.1053/j.gastro.2010.06.019
  • 12. Cooper AZ, Gupta A, Odom SR. Conservative management of a bilothorax resulting from blunt hepatic trauma. Ann Thorac Surg 2012;93:2043-2044. https://doi.org/10.1016/j.athoracsur.2011.11.024
  • 13. Austin A, Fox N, Huggins JT, Chopra, A. The green pleural effusion: a comprehensive review of the bilothorax with case series. The Official Journal of the International Society of Pleural Diseases. Pleura 2017;4:21-31. https://doi.org/10.1016/j.amjms.2017.03.034
There are 12 citations in total.

Details

Primary Language English
Subjects Clinical Sciences (Other)
Journal Section Case Report
Authors

Nilüfer Yiğit 0000-0002-5871-6461

Ali Rıza Kük 0009-0004-4215-8807

Kamil Fatih Türker 0000-0003-3884-9475

Göksel Altınışık Ergur 0000-0001-6869-1301

Early Pub Date July 2, 2024
Publication Date
Submission Date May 21, 2024
Acceptance Date June 30, 2024
Published in Issue Year 2025 Volume: 18 Issue: 1

Cite

APA Yiğit, N., Kük, A. R., Türker, K. F., Altınışık Ergur, G. (2024). When the pleural fluid appears in an unexpected color: a bilothorax case. Pamukkale Medical Journal, 18(1), 20-20. https://doi.org/10.31362/patd.1487005
AMA Yiğit N, Kük AR, Türker KF, Altınışık Ergur G. When the pleural fluid appears in an unexpected color: a bilothorax case. Pam Med J. July 2024;18(1):20-20. doi:10.31362/patd.1487005
Chicago Yiğit, Nilüfer, Ali Rıza Kük, Kamil Fatih Türker, and Göksel Altınışık Ergur. “When the Pleural Fluid Appears in an Unexpected Color: A Bilothorax Case”. Pamukkale Medical Journal 18, no. 1 (July 2024): 20-20. https://doi.org/10.31362/patd.1487005.
EndNote Yiğit N, Kük AR, Türker KF, Altınışık Ergur G (July 1, 2024) When the pleural fluid appears in an unexpected color: a bilothorax case. Pamukkale Medical Journal 18 1 20–20.
IEEE N. Yiğit, A. R. Kük, K. F. Türker, and G. Altınışık Ergur, “When the pleural fluid appears in an unexpected color: a bilothorax case”, Pam Med J, vol. 18, no. 1, pp. 20–20, 2024, doi: 10.31362/patd.1487005.
ISNAD Yiğit, Nilüfer et al. “When the Pleural Fluid Appears in an Unexpected Color: A Bilothorax Case”. Pamukkale Medical Journal 18/1 (July 2024), 20-20. https://doi.org/10.31362/patd.1487005.
JAMA Yiğit N, Kük AR, Türker KF, Altınışık Ergur G. When the pleural fluid appears in an unexpected color: a bilothorax case. Pam Med J. 2024;18:20–20.
MLA Yiğit, Nilüfer et al. “When the Pleural Fluid Appears in an Unexpected Color: A Bilothorax Case”. Pamukkale Medical Journal, vol. 18, no. 1, 2024, pp. 20-20, doi:10.31362/patd.1487005.
Vancouver Yiğit N, Kük AR, Türker KF, Altınışık Ergur G. When the pleural fluid appears in an unexpected color: a bilothorax case. Pam Med J. 2024;18(1):20-.

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