Pulmoner Emboli Olan Hastalarda Fibrinojen/Albümin Oranı

Year 2023, , 67 - 70, 01.07.2023

Abdullah Bilge , Ali Duman , Kenan Türkdoğan , Ayhan Aköz

https://doi.org/10.38175/phnx.1202390

Abstract

Amaç: Pulmoner emboli teşhis edilemediğinde yüksek ölüm oranı ile ilişkilidir. Amacımız fibrinojen/albümin oranı ile pulmoner emboli arasındaki ilişkiyi araştırmaktı.
Gereç ve Yöntem: PE olduğundan şüphelenilen ve rutin kan testi yapılan hastalar bu prospektif çalışmaya dahil edilmiştir. Fibrinojenleri ve albümin değerleri değerlendirildi.
Bulgular: Çalışmaya toplam 130 hasta dahil edildi. PE, hastaların 71’inde (%54) tespit edildi. Bunlardan 7’si (%9,9) subsegmental, 50’si (%70,4) segmental ve 14’ü (%19,7) masif idi. Kontrol grubundaki deneklerin FAR(Fibrinojen albumin oranı) ‘si 99.1 (75.2–167.9) iken, PE grubundaki FAR 151 (125.1–220.5) olup, kontrol grubundan anlamlı derecede yüksekti (P < 0,001). PE grubunda ROC analizi yapıldığında FAR önemli bir öngörücü faktör oldu (AUC: 0.724; %95 GA = 0.635-0.814; P < 0.001). FAR, duyarlılık %77.5 ve özgüllük %61.0 idi.
Sonuç: PE’li hastalarda fibrinojen düzeyleri ve FAR anlamlı olarak daha yüksekti.

Keywords

Pulmoner emboli, fibrinojen/albümin oranı, ortalama trombosit hacmi

Supporting Institution

ADNAN MENDERES ÜNİVERSİTY

Project Number

TPF-17043

Fibrinogen/Albumin Ratio in Patients with Pulmonary Embolism

Abstract

Objective: Pulmonary embolism is associated with a high mortality rate when it is not diagnosed emergently. Our aim was to investigate the relationship between the fibrinogen/albumin ratio and pulmonary embolism.
Material and Method: Patients who were suspected to have pulmonary embolism and who underwent routine blood testing to initiate the diagnostic process were included in this prospective study. Their fibrinogen and albumin values were evaluated.
Results: A total of 130 patients were included in the study. Pulmonary embolism was detected in 71 (54%) of the patients. Of those, 7 (9.9%) were subsegmental, 50 (70.4%) were segmental, and 14 (19.7%) were massive pulmonary. The fibrinogen/albumin ratio of the subjects in the control group was 99.1 (75.2–167.9), whereas the fibrinogen/albumin ratio in the pulmonary embolism group was 151 (125.1–220.5), significantly higher than the control value (P < 0.001). When ROC analysis was performed in the pulmonary embolism group, the fibrinogen/ albumin ratio was found to be a significant predictive factor (AUC: 0.724; 95% CI = 0.635–0.814; P < 0.001). When the fibrinogen/albumin ratio was 119.3, the sensitivity was 77.5%, and specificity was 61.0%.
Conclusion: Fibrinogen levels and fibrinogen/albumin ratio were significantly higher in patients with pulmonary embolism.

Keywords

Pulmonary embolism, fibrinogen/albumin ratio, mean platelet volume, Pulmoner emboli, fibrinojen/albümin oranı, ortalama trombosit hacmi

Project Number

TPF-17043

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